70 results about "2-Furoic acid" patented technology

The invention relates to the technical field of bio-based polyester synthesis, in particular to a preparation method of poly (ethylene 2, 5-furandicarboxylate). Comprising the following steps: purification of 2, 5-furandicarboxylic acid: purifying the 2, 5-furandicarboxylic acid by sequentially adopting activated carbon, dealdehyding resin and a modified adsorbent, so that the content of acyl furoic acid, furoic acid and aldehyde impurities can be effectively reduced, side reactions are reduced, and the chroma of a finished product is reduced. Adding the purified 2, 5-furandicarboxylic acid, ethylene glycol, a composite catalyst and a composite stabilizer into a reaction container, and carrying out esterification reaction and polycondensation reaction to obtain 2, 5-furandicarboxylic acid glycol ester; a mixture of aluminum acetylacetonate, antimony triphenyl diacetate and zinc acetate is used as a catalyst of poly (ethylene 2, 5-furandicarboxylate), so that the color of PEF can be effectively improved.

The invention discloses a biological detoxification and resource utilization method for a lignocellulose pretreatment solution based on Kurthia huakuii, and belongs to the technical field of environmental protection. According to the method, bacteria are inoculated into lignocellulose pretreatment liquid, and toxic substances in the lignocellulose pretreatment liquid are subjected to biological detoxification. Kurthia huakuii can convert furfural into low-toxicity furfuryl alcohol and furoic acid, and meanwhile, furfuryl alcohol, furoic acid and vanillin can act as an organic carbon source to be used for biomass accumulation, so that resource utilization of the lignocellulose pretreatment liquid is achieved.

A method for producing a furoic acid derivative may include an oxidation step of oxidizing a furfural derivative to obtain a furoic acid derivative in the reaction system of pH 3-12. A method for producing a furan derivative may include a decarboxylation step of decarboxylating a furoic acid derivative to obtain a furan derivative without using a catalyst, using an oxide of mono-to tri-valent transition metal as a catalyst, or using a high boiling point solvent. A method for producing a furan derivative may include the oxidation step of obtaining a furoic acid derivative and the decarboxylation step of obtaining a furan derivative. A method for producing a phthalocyanine derivative or an isoindoline derivative may include obtaining a phthalocyanine derivative or an isoindoline derivative from the furan derivative obtained by any one of the methods for producing a furan derivative.

The present invention belongs to the field of furyl biomass chemicals and materials. Disclosed is a method for synthesizing 2,5-furandicarboxylic acid by means of the carbonylation of furoic acid. The method comprises: adding furoic acid and an organic alkali into a two-phase solvent system, separating two phases after the reaction is finished, adding an organic acid into the aqueous phase, filtering same, collecting a precipitate, then washing the precipitate, and drying same to obtain 2,5-furandicarboxylic acid, wherein the two-phase solvent system is a mixture of a basic metal salt solution and a biomass-based polar aprotic solvent, and a CO2-supplying reagent is added or not added into the two-phase solvent system. The synthesis process and the separation and purification process are simple, the product purity is relatively high, the carbonylation reaction rate is high, the raw material cost is reduced, and the green chemical development concept is satisfied.

The present invention relates to cleaning compositions comprising low levels of hydrogen peroxide and at least one acid selected from the group consisting of salicylic acid, furoic acid and formic acid. The compositions and methods of the invention are particularly suitable for use in household cleaning, for example in hard-surface cleaning or cleaning soft surfaces such as textiles and laundry.

The invention discloses lysinibacillus fusiformis, which is classified and named as lysinibacillus fusiformis B2P, is preserved in the China Center for Type Culture Collection on November 10, 2020, and has the preservation number of CCTCC NO: M 2020723. The invention also discloses an application of the Lysinibacillus sp. B2P in catalytic synthesis of 5-hydroxymethyl furoic acid, the strain has high tolerance to HMF, can be used as a biocatalyst to selectively convert HMF into a target product HMFCA, and the yield is high. By adopting the lysinibacillus sp. B2P disclosed by the invention, not only can higher substrate concentration and higher reaction efficiency than those of a previously reported biological catalysis method be realized, but also the selectivity is improved. In addition, mild conditions are convenient to control, and subsequent separation and purification of a target product are simplified.

This invention relates to the application of 5-(tetradecoxy)-2-furoic acid (TOFA) in the preparation of drugs that inhibit osteoclast differentiation and function. Using a RANKL-induced mouse bone marrow macrophage osteoclast differentiation model, experiments demonstrated that TOFA can effectively inhibit osteoclast differentiation and function by inhibiting ROS and downregulating the expression of key osteoclast differentiation and function proteins such as Nfatc1, Src, and Ctsk. Furthermore, TOFA at concentrations of 40 μM and below showed no significant cytotoxicity, proving that TOFA can serve as a candidate compound for developing drugs that inhibit osteoclast differentiation and function, and for treating diseases caused by excessive activation of osteoclasts, thus possessing significant clinical application value. Additionally, by constructing a mouse ovariectomized osteoporosis model, the preventive and therapeutic effects of TOFA on estrogen-deficiency-induced osteoporosis were demonstrated.

The invention discloses preparation and application of furoic acid and a bactericidal composition thereof, and relates to the technical field of biopesticides, the furoic acid comprises furoic acid, the chemical structural formula of the furoic acid is shown in the specification, the purity is greater than or equal to 98%, and the furoic acid is prepared by the following steps: mixing furfural, a sodium hydroxide aqueous solution and copper oxide, introducing oxygen at 50-60 DEG C, stirring and reacting for 4-6 hours, and filtering to obtain a filtrate; extracting, acidifying, recrystallizing and drying to obtain furoic acid; according to the preparation and application of the furoic acid and the bactericidal composition thereof, the furoic acid with a specific structure is scientifically compounded with screened specific biopesticides (kasugamycin, boscalid and ningnanmycin), and the ratio range (for example, the ratio of furoic acid to kasugamycin is 1: 10-10: 1) with a remarkable synergistic effect is optimized and determined; according to the composition disclosed by the invention, the components are effectively complemented on the action mechanism, and the defects that the traditional single pesticide is single in action target and easy to induce drug resistance are overcome, so that the overall control effect of the composition on various plant diseases (including bacteria, fungi and virus diseases) is remarkably improved.

The invention provides a method for preparing 5-formyl furoic acid, and relates to the technical field of biological platform compounds. According to the method for preparing the 5-formyl furoic acid, a solution composed of substrates HMF, TEMPO, acid, salt and a solvent is subjected to an oxidation reaction under oxidizing gas, and the 5-formyl furoic acid is obtained. The salt is selected from nitrite and / or nitrate. According to the method, the HMF conversion rate is high, and the FFCA selectivity is high.

The invention discloses an efficient gas-slag separation device suitable for furoic acid processing, and belongs to the technical field of furoic acid processing.The efficient gas-slag separation device suitable for furoic acid processing comprises a separation tank, a gas inlet pipe is arranged on the upper portion of the separation tank, a connecting ring cover is arranged at the top of the separation tank, and a second filtering assembly is movably arranged on the connecting ring cover; a supporting rotating disc is rotationally arranged on the connecting ring cover, an air guide pipe communicating the separating tank with the second filtering assembly is arranged on the supporting rotating disc, a rotating assembly connected with the supporting rotating disc is arranged on the connecting ring cover, a first filtering assembly is arranged in the separating tank, and the first filtering assembly penetrates through the supporting rotating disc and is movably connected with the second filtering assembly; and a reciprocating adjusting assembly connected with the air guide pipe is arranged between the connecting ring cover and the second filtering assembly. The multi-filtering and multi-separation type filter has the advantages of multiple filtering, high-efficiency separation, double blockage prevention, flexible linkage, reliable structure, simplicity, convenience and practicability.

Methods for producing biomonomers and precursors thereof. A carboxylation reaction is carried out between an aromatic hydrocarbon, such as a furoic acid compound, and a dicarboxylated basic salt. The reaction produces a carboxylated aromatic hydrocarbon and a decarboxylated basic salt. The carboxylated aromatic hydrocarbons can be isolated and used to produce biomonomers such as methyl furandicarboxylate and furandicarboxylic acid. The decarboxylated basic salt can be regenerated.

The present disclosure provides compositions and methods for the production of dihydrofuran by a glycosyl hydrolase enzyme capable of dehydrating 2-keto-3-deoxygluconic acid (KDG) to K4. Also provided are compositions and methods for further processing K4 to produce HMFA (5-hydroxymethyl-2-furoic acid) and / or FDCA (2, 5-furandicarboxylic acid).

The invention discloses a CoPt0. 05-coated Co3O4-NC catalyst for synthesizing ethyl valerate as well as a preparation method and application of the CoPt0. 05-coated Co3O4-NC catalyst. The method comprises the following steps: injecting a cobalt salt solution into an organic ligand solution, stirring, centrifuging and drying to obtain ZIF-67; dispersing into an organic acid solution, stirring, centrifuging and drying to obtain CA-ZIF-67; after calcination, Co-coated Co3O4-NC is obtained; and carrying out galvanic couple replacement to obtain the CoPt < 0.05 > and Co3O4-NC. The material shows excellent performance in a reaction of synthesizing ethyl valerate through one-pot esterification-hydrogenolysis of 2-furoic acid and ethanol, and the catalyst is simple to separate and good in cycling stability, can be reused after being washed and dried, still keeps higher catalytic activity after being used for multiple times, and has a wide application prospect. The problems of tedious steps, low efficiency, poor catalyst activity, poor stability and the like of current ethyl valerate synthesis are effectively solved, and the method has a good industrial application prospect.

This invention discloses an electrocatalyst with enhanced catalytic performance through an ohmic contact and its applications. A NiMo alloy is anchored on the surface of a semiconductor NiCuP microflower using electrodeposition. By precisely controlling the work function matching between NiMo and NiCuP, an ohmic contact heterointerface is successfully constructed. This effectively eliminates the Schottky barrier at the heterostructure interface and removes the energy barrier for interfacial charge transport, thereby significantly optimizing the intrinsic conductivity of the catalyst and accelerating the transfer of electrons from the catalyst interior to the surface active sites. Benefiting from this efficient interfacial electron transport channel, the catalyst exhibits significantly enhanced catalytic activity in the cathode hydrogen evolution reaction. In the anodic half-reaction, a more thermodynamically favorable FOR is used instead of OER, enabling energy-saving hydrogen production by coupling the cathode HER at a lower battery voltage. Simultaneously, at the anode, furfural, a biomass-derived platform molecule, is efficiently converted into high-value-added furoic acid.

The invention discloses a carrier-free mometasone furoate dry powder inhaler and a preparation method thereof, and relates to the technical field of pharmaceutical preparations, the carrier-free mometasone furoate dry powder inhaler comprises mometasone furoate and an excipient, and the preparation method comprises the following steps: firstly, mixing mometasone furoate and the excipient according to a mass ratio of 10: 90-90: 10, transferring into a beaker, adding a proper amount of water, stirring, and carrying out suction filtration; adding an ethanol-water mixed solution, and stirring until solids are completely dissolved to obtain a spray-dried raw material solution; carrying out spray drying on the spray drying raw material solution by adopting a spray dryer, and collecting a product after drying to obtain microspheres, namely the carrier-free mometasone furoate dry powder inhalant. According to the carrier-free mometasone furoate dry powder inhalant, lactose does not need to be used as a carrier, the allergy risk possibly caused by lactose is avoided, meanwhile, a microsphere structure with the surface wrinkled is formed through a spray drying technology, the medicine mainly exists in an amorphous state, and the dispersity and solubility of mometasone furoate are remarkably improved.

The present invention relates to improved compositions for cleansing dental appliances comprising hydrogen peroxide and at least one acid selected from the group consisting of salicylic acid, furoic acid and formic acid.

The invention provides a method for synthesizing 2, 5-furandicarboxylic acid through furoic acid and bicarbonate, and relates to the technical field of chemical synthesizing.The method for synthesizing 2, 5-furandicarboxylic acid through furoic acid and bicarbonate comprises the following steps that raw materials including furoic acid, basic metal salt and bicarbonate are taken and placed in water to react, drying and smashing are conducted after the reaction is completed, and the furoic acid is obtained; the bicarbonate comprises cesium bicarbonate, and the furoic acid solid mixture is obtained; taking the furoic acid solid mixture, placing the furoic acid solid mixture under the pressure of 0.8-2MPa, heating to 240-320 DEG C, and reacting for more than 15 hours to obtain 2, 5-furandicarboxylate; and dissolving the 2, 5-furandicarboxylic acid salt in water, and acidifying with hydrochloric acid to obtain the 2, 5-furandicarboxylic acid. The bicarbonate is heated and decomposed to generate carbon dioxide, the carbon dioxide produces a large number of pores in the furoic acid solid mixture, the gas-solid interface surface area is greatly increased, the gas-solid interface reaction is accelerated, the gas-liquid reaction efficiency is improved, and the energy consumption is reduced.

This invention relates to solid waste resource utilization technology and discloses a solid waste recycling device for furfurylic acid processing, comprising an anaerobic pyrolysis carbonization furnace and a protective gas flow adaptive adjustment system. The adjustment system includes: a safety risk assessment module, which obtains a safety monitoring coefficient based on combustible gas concentration and temperature gradient; a processing load sensing module, which obtains a load coefficient based on feed rate and gas production flow; a comprehensive demand decision module, which obtains a comprehensive demand coefficient based on the load coefficient, safety monitoring coefficient, waste moisture content, and particle size; an operational stability monitoring module, which obtains a stability coefficient based on multi-point oxygen concentration and furnace pressure; and a flow precision control module, which calculates the target nitrogen flow rate based on the larger value of the comprehensive demand coefficient and the stability coefficient and adjusts it in real time. This invention achieves dynamic and precise control of the protective gas flow rate through multi-source parameter fusion and nonlinear decision-making, optimizing operational energy consumption and pyrolysis efficiency while ensuring the safety of the anaerobic environment.

The invention discloses high-stability mometasone furoate emulsifiable paste and a processing technology thereof, and relates to the technical field of emulsifiable paste preparations. A double-emulsification-system preparation process is adopted, the stability of the cream is remarkably improved, firstly, main drug active ingredients are prepared into submicron emulsion through dispersion and homogenization to form a first emulsification system (W / O) to play a role in primary protection, secondly, dispersion is added into a water phase to form an oil-in-water particle structure, and then the dispersion and an oil phase are emulsified to form a second emulsification system (O / W / O) to play a role in secondary protection. The mometasone furoate emulsifiable paste with high stability is prepared by adding auxiliary materials such as titanium dioxide and starch aluminum octenylsuccinate, so that the bioavailability of mometasone furoate is improved; by cooperating with excellent oxidation resistance of 4-vinyl guaiacol, gallic acid and glycyrrhizic acid, the oxidation resistance of the cream is remarkably improved, and the long-acting stability of the cream is further ensured.

The present invention relates to the technical field of hydrogen production, and aims to provide a device and method for producing hydrogen by bipolar electrolysis of furfural oxidation coupled with acid-base imbalance. The device comprises an electrolytic cell, an anode alkaline electrolyte circulation system, a cathode acidic electrolyte circulation system, a hydrogen washing and drying system, and a monitoring and control system; the electrolytic cell has a closed cavity, and the anode and the cathode are respectively arranged in two reaction chambers; the anode electrolyte is an alkaline mixed solution prepared with furfural and alkali solution; the cathode electrolyte is an acidic solution. The present invention can realize the simultaneous hydrogen evolution at the cathode and the anode during the electrolysis process accompanied by the generation of furfural acid, thereby reducing the energy consumption of hydrogen production and achieving high value of the product. The equipment avoids the use of high-energy-consuming auxiliary devices and reduces the overall energy consumption of the equipment. By replacing the oxygen evolution reaction with the furfural oxidation reaction, the electrolysis starting potential is greatly reduced, thereby achieving a huge optimization of energy consumption compared with the traditional water electrolysis hydrogen production technology; increasing the efficiency of electric energy utilization and improving the safety of the reaction.

The present application belongs to the technical field of fine chemical product purification, and particularly relates to a high-purity furfuryl acid purification method. The method is directed to a crude furfuryl acid obtained after pretreatment of a furfuryl alcohol oxidation reaction liquid, and a combined purification process of "double-agent synergistic decolorization-vacuum concentration-double-solvent gradient recrystallization" is innovatively adopted. First, the crude furfuryl acid is deeply decolorized with a composite system of activated carbon and diatomite, and organic pigments, small particles and metal ions are simultaneously removed. Then, the crude furfuryl acid is sequentially subjected to step-by-step recrystallization with deionized water and an ethanol-water mixed solvent, and trace by-products are accurately separated. Finally, vacuum drying is performed, and a high-purity furfuryl acid product with a purity of greater than or equal to 99.9% is finally obtained. Compared with the existing single decolorization or single solvent recrystallization process, the present application has high efficiency and strong compatibility, and can be realized by small-scale modification on the basis of the existing furfuryl acid production equipment, is suitable for large-scale production, and fills the gap of high-purity furfuryl acid purification and large-scale production in the prior art.

The invention discloses a method for preparing 2,3-benzofuran by a one-pot method using furoic acid catalyzed by a halogen acid. The steps of the method are as follows: 1) adding a solvent and a halogen acid to a high-temperature and high-pressure reactor with stirring and lined with polytetrafluoroethylene, starting stirring, and then adding furoic acid; 2) heating to a reaction temperature of 100 to 150° C., and reacting in a one-pot method for 2 to 24 hours; 3) cooling to room temperature after the reaction to obtain a reaction product, and then separating to obtain a 2,3-benzofuran product. The present invention adopts a one-pot method to prepare 2,3-benzofuran from furoic acid, has a short process route, mild conditions, and a 2,3-benzofuran yield of up to 75.0%, and has a very broad prospect for industrial application.

The invention relates to electronic atomization liquid with sweet aftertaste, a preparation method and an electronic atomization device. The electronic atomized liquid with the sweet aftertaste is prepared from the following components in parts by weight: 0 to 99.9979 parts of a solvent, 0.002 to 15 parts of a sweetening agent and 0.0001 to 20 parts of sweet aftertaste molecules. The after-sweetness molecules comprise 2-furoic acid, quercetin, 4-hydroxybenzaldehyde, methyl gallate and ethyl 3, 4, 5-trimethoxy benzoate, and the after-sweetness molecules comprise 2-furoic acid, quercetin, 4-hydroxybenzaldehyde, methyl gallate and ethyl 3, 4, 5-trimethoxy benzoate. According to the electronic atomized liquid provided by the invention, the sweetening agent and the sweet aftertaste molecules in proper parts by weight are matched to realize relatively high initial sweetness, and the sweet aftertaste molecules do not have any sweetness but form a very three-dimensional natural sweet aftertaste after being combined with the sweetening agent.

The present invention relates to a water-soluble film containing mometasone furoate, adjusted to a pH in the range of 3.5 to 5.0. Adjusting the pH improves the stability of the active ingredient without significantly affecting the mechanical properties of the film. The present invention further relates to methods for producing such films, pharmaceutical dosage forms containing such films in a capsule, and methods for producing such pharmaceutical dosage forms. The pharmaceutical dosage form can be used, in particular, for the treatment of eosinophilic esophagitis.

The invention belongs to the crossing field of chemistry and chemical engineering and energy, and particularly relates to a preparation method of 2, 5-furandicarboxylic acid (FDCA), which comprises the following steps: 1) oxidizing furfural by using a nitrogen-doped carbon supported metal cobalt-based catalyst, molecular oxygen as an oxidant and cesium carbonate as an alkali additive to obtain furoic acid; and 2) reacting the mixture obtained by drying the filtrate with CO2 at high temperature, and acidifying with dilute acid to obtain FDCA. A mixture obtained after the filtrate is dried contains cesium furoate and cesium carbonate, wherein cesium carbonate is used for promoting carboxylation of a C-H bond on the C5 site of cesium furoate. The conversion rate of furfural is 99.5%, the selectivity of furoic acid is 99.7%, the yield of FDCA is 81%, and the purity is 99%. The non-precious metal cobalt single atom is adopted as the catalyst, the catalytic efficiency is far higher than that of nanoparticles, and the catalyst can be repeatedly utilized; the reaction process is green and friendly, and the process is simple and easy to amplify; the cheap furfural is used for replacing expensive 5-hydroxymethylfurfural (5-HMF), and a route for preparing FDCA from C5 is developed; greenhouse gas CO2 is fixed and reduced in emission, resource utilization is achieved, and comprehensive benefits are remarkable.

The invention relates to the technical field of determination methods, in particular to a liquid chromatography for determining a compound electrolyte injection (V), which comprises the following steps of: 1, debugging a liquid chromatograph, and adjusting the chromatography of the liquid chromatograph to be that sulfonic acid type polystyrene and divinylbenzene copolymer cation exchange resin H type is used as a filling agent; a 0.025 mol / L sulfuric acid solution is used as a mobile phase; the flow rate is 1.0 ml per minute; the column temperature is 60 DEG C; the detection wavelength is 210 nm; the sample injection volume is 100 to 250 [mu] l; 2, preparing a reference substance solution corresponding to the compound electrolyte injection (V), injecting the reference substance solution into a liquid chromatograph, and recording a corresponding chromatogram; and 3, injecting the compound electrolyte injection (V) to be detected into the liquid chromatograph, recording a corresponding chromatogram, and obtaining the contents of sodium gluconate and sodium acetate and the contents of D-glucuronic acid and 5-hydroxymethyl-2-furoic acid in the compound electrolyte injection (V) through a formula.

The invention provides furyl polyamide as well as a preparation method and a recovery method thereof. The preparation method of the furyl polyamide comprises the following steps: under the protection of inert gas, adding 5-amino furoic acid, a phosphite ester catalyst, an alkaline initiator and a lithium ion activator into a polar solvent, and carrying out polymerization reaction at the polymerization temperature of 40-200 DEG C to obtain the furyl polyamide, wherein the molar ratio of the 5-amino furoic acid to the phosphite ester catalyst to the alkaline initiator to the lithium ion activating agent to the polar solvent is 1: (0.5-2): (0.1-0.5): (0.01-0.2): (1-10).

The application discloses a kind of electrochemical oxidation-membrane separation coupling green preparation furfuryl acid method.The method uses industrial grade furfural as raw material, selects transition metal composite electrode as anode, multiple electrode as cathode, and carries out electrochemical oxidation reaction in alkaline electrolyte system;Reaction solution is removed inorganic impurities by anion exchange membrane separation, and then refined by acidification crystallization and vacuum sublimation, to obtain high-purity furfuryl acid.The application constructs "electrochemical oxidation-membrane separation-sublimation refining" coupling system, without additional chemical oxidant, by low-cost composite electrode optimization catalytic performance, combined with membrane separation and vacuum sublimation synergistic purification, solve the problems of low product purity, large wastewater discharge, high energy consumption in traditional process, meet the requirements of green chemical industry, and can be widely used in medicine, pesticide, high-end perfume and other fields.

The present invention relates to compounds derivable from the esterification of a fatty alcohol and furoic acid according to Formula (I). The present invention also relates to the use of said compounds as surfactants, compositions comprising said compounds, and the manufacture of said compounds.

The invention discloses a method for synthesizing 2,5-furandicarboxylic acid by carbonylation of furanic acid, and belongs to the field of furan-based biomass chemicals and materials. The method adds furanic acid and an organic base into a two-phase solvent system, separates the two phases after the reaction is completed, adds an organic acid into the aqueous phase, collects the precipitate by filtration, then washes the precipitate, and dries it to obtain 2,5-furandicarboxylic acid; wherein the two-phase solvent system is a mixture of a basic metal salt solution and a biomass-based polar aprotic solvent, and a CO2 supply reagent is added or not added to the two-phase solvent system. The synthesis process and separation and purification process of the invention are simple, the product purity is high, the carbonylation reaction rate is high, the raw material cost is reduced, and it conforms to the concept of green chemistry development.