8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolbenzo[1,4]benzodiazepine for forensic science, preparation method therefor and application of 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolbenzo[1,4]benzodiazepine

Abstract

The invention discloses 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolbenzo[1,4]benzodiazepine with a structure represented by a formula shown in the description. A preparation method for the8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolbenzo[1,4]benzodiazepine comprises the following steps: (1) synthesizing a compound B from a compound A; (2) synthesizing a compound C from the compound B; and (3) synthesizing the 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolbenzo[1,4]benzodiazepine compound D from the compound C. Shown by application researches on the 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolbenzo[1,4]benzodiazepine, the prepared 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolbenzo[1,4]benzodiazepine can be applied to reference materials for detection and identification work of organs of public security. The technical scheme of the invention achieves the following beneficial technical effects that an optimal synthesis route for synthesizing the 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolbenzo[1,4]benzodiazepine is optimized; the target object, i.e., the 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolbenzo[1,4]benzodiazepine is separated and purified, and thus, the purity of the 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolbenzo[1,4]benzodiazepine reaches 99% or more; and the prepared 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-[1,2,4]triazolbenzo[1,4]benzodiazepine can directly serve as a reference substance for the detection and identification work of the organs of public security.

Description

technical field [0001] The invention relates to the technical field of forensic science poisons. Specifically, fluclozolam for forensic science and its preparation method and application. Background technique [0002] Since 2017, there have been many narcotic rape cases across the country. The suspects bought liquids with unknown ingredients marked with "diffuse night", "obsession", "hunting beauty" and "feeling love" online, and mixed them into drinks and drinks. The woman was tricked into drinking it, and the woman quickly lost consciousness and resistance after drinking the wine and beverages containing medicinal ingredients. When the public security organs in various places screened the confiscated drugs and the victim's biological sample blood and urine with immunocolloidal gold reagent strips, the benzodiazepine reagent strips were positive, but most of them could not be tested by instruments. Publish the drug ingredients in the "Catalogue of Narcotic Drugs and Psych...

AI Technical Summary

Problems solved by technology

This substance is the latest planned benzodiazepine drug synthesized by criminals. There is a lack of standard substances at home and abroad, and the public security organs are often unable to issue inspection reports and effectively crack down on criminal suspects.

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