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Positive ion mobility spectrometry detection method for propofol in exhaled air

An ion transfer tube and positive ion technology, applied in measuring devices, material analysis through electromagnetic means, instruments, etc., can solve the problems of inability to realize real-time online monitoring of exhaled gas, long response time, etc., and achieve continuous clinical online monitoring, Eliminate the interference of humidity, the effect of eliminating interference

Inactive Publication Date: 2019-05-21
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the combination of MCC and membrane sampling device, the response time of IMS is as long as minutes, and real-time online monitoring of exhaled breath cannot be realized.

Method used

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  • Positive ion mobility spectrometry detection method for propofol in exhaled air
  • Positive ion mobility spectrometry detection method for propofol in exhaled air
  • Positive ion mobility spectrometry detection method for propofol in exhaled air

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Using reagent molecule-assisted photoionization positive ion mobility spectrometry, when the reagent molecules are benzene, toluene, o-xylene, p-xylene and ethylbenzene, their reduced reagent ion mobility is 2.22, 2.07, 1.95, 1.96 and 1.96cm 2 V -1 the s -1 ,Such as image 3 shown.

Embodiment 2

[0070] 3ppbv propofol was detected by reagent molecule-assisted photoionization positive ion mobility spectrometry, and when the reagent molecules were benzene, toluene, o-xylene, p-xylene and ethylbenzene, the reduced mobility of propofol product ions were all 1.50 cm 2 V -1 the s -1 ,Such as Figure 4 shown.

Embodiment 3

[0072] Simultaneous detection of 3ppbv propofol and sevoflurane by reagent molecule-assisted photoionization positive ion mobility spectrometry, when the reagent molecule is toluene, the reduced mobility of the toluene reagent ion is 2.07cm 2 V -1 the s -1 , the reduced mobility of the propofol product ion peak is 1.50cm 2 V -1 the s -1 , sevoflurane has no signal response, and the interference of sevoflurane in compound anesthesia is eliminated in positive ion mode, such as Figure 5 shown.

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Abstract

The invention discloses a positive ion mobility spectrometry detection method for propofol in exhaled air. The method is based on a time resolution dynamic dilution sampling device and a reagent molecule-assisted photoionization positive ion mobility spectrometry technology. Time-resolved dynamic dilution sampling of propofol molecules and water molecules in exhaled air is achieved, influences ofhumidity in the exhaled air and sevoflurane in composite anesthesia are eliminated, the propofol is quantified through signal intensity of the 2s propofol of time-resolved dynamic dilution sampling, and clinical continuous online monitoring of the propofol in the exhaled air is achieved.

Description

technical field [0001] Based on the time-resolved dynamic dilution sampling device and the reagent molecule-assisted photoionization positive ion mobility spectrometry technology, the present invention designs a time-resolved dynamic dilution sampling ion mobility spectrometry detection method, which realizes the detection of propofol and exhaled gas The time-resolved dynamic dilution sampling detection of medium humidity eliminates the influence of the humidity in the exhaled air and the inhalation anesthetic sevoflurane, and quantifies it by using the signal intensity of propofol in the second second of the injection, realizing the propofol in the exhaled air continuous online monitoring. Background technique [0002] Propofol is a commonly used intravenous anesthetic and is currently used in more than 50 countries. During the operation, reliable anesthesia monitoring is an important guarantee for the life safety of patients. Studies have shown that online monitoring of p...

Claims

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Application Information

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IPC IPC(8): G01N27/62
Inventor 李海洋蒋丹丹王新鞠帮玉肖瑶
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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