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A kind of cistanche extract and its preparation method and application

A Cistanche deserticola extract and the extract technology are applied in the directions of pharmaceutical formulations, drug combinations, plant raw materials, etc., which can solve the problems of restricting the use of patients, severe drug effects, etc., so as to increase the total amount of defecation, shorten the defecation time, and enhance intestinal propulsion. effect of function

Active Publication Date: 2021-10-08
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the commonly used Chinese patent medicines such as Maren Runchang Pills, Niuhuang Jiedu Pills, Longdan Xiegan Pills, etc. have good clinical curative effects and play a great role in the treatment of constipation, but these medicines have common shortcomings. It belongs to the medicine of "Junxia Chasing Water", which has a strong effect, and most of the patients with constipation are elderly and physically weak patients, which restricts the use of most patients.

Method used

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  • A kind of cistanche extract and its preparation method and application
  • A kind of cistanche extract and its preparation method and application
  • A kind of cistanche extract and its preparation method and application

Examples

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Effect test

preparation example 1

[0024] Take Cistanche medicinal material (dried succulent stem with scaly leaves of Cistanche diserticola Y.C.Ma), crush to 24 mesh, add 70% ethanol solution of 10 times the amount of medicinal material and extract under reflux for 2 hours, the extraction temperature is 75-80°C, and the extraction times are 3 Once, the filtrates were combined, and the filtrates were for subsequent use; the above-mentioned filtrates were concentrated under reduced pressure to no alcohol smell, and centrifuged to obtain a concentrated solution with a relative density of 1.01kg / L; the concentrated solution was placed at room temperature and passed through an ADS-17 macroporous resin column (Zhengzhou Qinshi Technology Co., Ltd.), eluted with purified water, the amount of eluent was 5 times the column volume, collected water eluate, and concentrated under reduced pressure to obtain a concentrated solution with a relative density of 1.20kg / L, that is, the active extract of Cistanche deserticola , th...

preparation example 2

[0026] Take Cistanche medicinal material, crush it to 60 mesh, add 65% ethanol solution 20 times the amount of medicinal material, reflux and extract for 2 hours, the extraction temperature is 80-85°C, the extraction times are 4 times, the filtrate is combined, and the filtrate is set aside; the above-mentioned filtrate is concentrated under reduced pressure Centrifuge until there is no alcohol smell, and obtain a concentrated solution with a relative density of 1.02kg / L; place the concentrated solution at room temperature, pass through an AB-8 macroporous resin column (Zhengzhou Qinshi Science and Technology Co., Ltd.), and elute with purified water. The amount of dehydration is 4 times the column volume, the water eluate is collected, and concentrated under reduced pressure to a relative density of 1.23kg / L to obtain the active extract of Cistanche deserticola. The total oligosaccharide content in the extract is 39.2%, mannitol content of 25.0%, betaine content of 22.1%.

preparation example 3

[0028] Take Cistanche medicinal material, crush it to 30 mesh, add 20 times the amount of medicinal material in 60% ethanol solution to reflux extraction for 4 hours, the extraction temperature is 85-90°C, the extraction times is 2 times, the filtrate is combined, and the filtrate is set aside; the above filtrate is concentrated under reduced pressure Centrifuge until there is no alcohol smell, and obtain a concentrated solution with a relative density of 1.03kg / L; place the concentrated solution at room temperature, pass through an ADS-17 macroporous resin column (Zhengzhou Qinshi Science and Technology Co., Ltd.), and elute with purified water. The amount of dehydration is 6 times the column volume, the water eluate is collected, concentrated under reduced pressure to a relative density of 1.25kg / L, and the active extract of Cistanche deserticola is obtained. The total oligosaccharide content in the extract is 21.1%, mannitol The content of betaine is 6.8%, and the content of...

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Abstract

The invention discloses an extract of Cistanche deserticola and its preparation method and application. The preparation method of the extract has the advantages of simple process, easy operation and low cost. The total oligosaccharide content in the obtained extract is about 20-40%. The content of alcohol is about 5-25%, and the content of betaine is about 10-30%. The extract has laxative effect, can enhance intestinal propulsion function, shorten defecation time, increase total defecation, reduce colonic myoelectric amplitude, increase myoelectric peristalsis frequency or increase the positive expression of c-kit in colonic interstitial cells of Cajal , It can also significantly improve the inflammatory lesions of colon tissue.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to an extract of Cistanche deserticola and its preparation method and application. Background technique [0002] Constipation is a symptom of many diseases. With the development of the economy, the deterioration of the ecological environment and the acceleration of people's life rhythm, about 5.0% to 10.0% of the intestinal outpatients come to see a doctor because of constipation. Currently domestic and foreign clinical treatment of constipation mainly through the following approaches: 1, drug treatment should be based on the principles of low toxicity, small side effects, and small drug dependence, such as bulking agents and osmotic laxatives. Agonists may be added for slow transit constipation. For fecal impaction, cleansing enema once or short-term combined with stimulant laxatives to relieve impaction. Use bulking agents or osmotic laxatives after relief....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/64A61P1/10A61P29/00
Inventor 萧伟屠鹏飞殷洪梅高云佳常秀娟石子仪徐忠坤胡晗绯周军吴云王振中
Owner JIANGSU KANION PHARMA CO LTD
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