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Micromolecule toxin separated and purified from crude araneus ventricosus toxin and application of micromolecule toxin

A technology for separation and purification of the large-bellied garden spider, applied in the application, biocide, plant growth regulator, etc., to achieve the effect of strong effect and reliable results

Active Publication Date: 2019-07-12
HUNAN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At the same time, there is no report on the selective effect of these acetylpolyamine small molecules on insect sodium channels

Method used

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  • Micromolecule toxin separated and purified from crude araneus ventricosus toxin and application of micromolecule toxin
  • Micromolecule toxin separated and purified from crude araneus ventricosus toxin and application of micromolecule toxin
  • Micromolecule toxin separated and purified from crude araneus ventricosus toxin and application of micromolecule toxin

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Embodiment Construction

[0029] The present invention provides a small molecular toxin isolated and purified from the crude venom of E. grandis, the small molecule toxin isolated and purified from the crude venom of E. Ammonium small-molecule toxin, the relative molecular weight is 757.5112, nuclear magnetic resonance structure analysis, the molecular formula of the small-molecule toxin isolated and purified from the crude venom of Arachnid grandis is C 36 h 64 o 5 N 13 , whose structural formula is:

[0030]

[0031] The application of the small-molecule toxin isolated and purified from the crude venom of E. grandina provided by the present invention in insecticides or in neurobiological reagents and / or medicines, especially to block or completely block insect sodium ion channels way of application as a pesticide. When the small-molecule toxin isolated and purified from the crude venom of E. macula completely blocks the insect sodium ion channel, the concentration of the small-molecule toxin i...

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Abstract

The invention belongs to the technical field of chemistry and the chemical industry, and relates to a micromolecule toxin separated and purified from a crude araneus ventricosus toxin and applicationof the micromolecule toxin. The micromolecule toxin separated and purified from the crude araneus ventricosus toxin is a quaternary ammonium type micromolecule toxin, the relative molecular weight is757.5112, and through structure analysis of magnetic resonance imaging, the molecular formula of the micromolecule toxin separated and purified from the crude araneus ventricosus toxin is C36H64O5N13;the invention provides the micromolecule toxin which has selectivity activity to insects, is less influenced by pH, is higher and more stable in effects and is separated and purified from the crude araneus ventricosus toxin and application of the micromolecule toxin.

Description

technical field [0001] The invention belongs to the technical field of chemistry and chemical engineering, and relates to a small-molecule toxin and its application, in particular to a small-molecule toxin separated and purified from the crude venom of E. grandis, and its application. Background technique [0002] The large-bellied garden spider (Araneus ventricosus) is a medium-sized spider that feeds on insects, and belongs to the phylum Arthropoda, Araneus, Aranea, Orbidae, and Orb genus in classification. The arachnid is one of the most widely distributed spiders in the world, and its venom contains a large number of toxic components that can anesthetize or kill insects. Explore the structural and functional characteristics of these small-molecule toxins isolated and purified from the crude venom of E. grandis, and screen out precursor molecules that may be used as neurobiological research tool reagents, drugs and insecticides. At present, there are very few studies on ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/078A01N47/44A01P7/04
CPCC07K5/06139A01N47/44
Inventor 段志贵刘凯
Owner HUNAN NORMAL UNIVERSITY
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