Preparing method of N-acetyl-D-galactosamine

A technology of acetylamino semi-galactosamine, applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of high cost and complicated production methods, and achieve the effect of low cost and simple reaction process

Inactive Publication Date: 2019-08-23
南京博源医药科技有限公司
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Problems solved by technology

[0002] N-acetylgalactosamine plays an important role in anti-cancer and anti-ca

Method used

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Embodiment Construction

[0017] The steps of the preparation method of N-acetylgalactosamine disclosed in the present disclosure are as follows:

[0018] The acid binding agent composed of galactosamine hydrochloride, ethanol and sodium ethoxide was neutralized for 20-40 minutes, such as 20 minutes, 25 minutes, 30 minutes, 35 minutes and 40 minutes, and desalted to obtain galactosamine; The weight ratio of ethanol and sodium ethylate in the acid-binding agent is 1:4-6.

[0019] Add chitin enzyme liquid to the obtained galactosamine for fermentation, the chitin enzyme liquid contains 30-60g / L powdered chitin, including N acetylhexosaminidase, chitinase C and chitinase H, the concentration of chitinase C is greater than 0.35g / L, the concentration of chitinase H is greater than 0.07g / L, and the concentration of N-acetylhexosaminidase is 0.055g / L.

[0020] Fermentation is first carried out by high temperature sterilization, the sterilization temperature is 130 degrees, sterilization is 45 minutes, the fe...

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Abstract

The invention discloses a preparing method of N-acetyl-D-galactosamine. The problems that a preparing method of N-acetyl-D-galactosamine is complicated and high in cost are solved. The preparing method is characterized in that firstly, galactosamine is generated, chitinase liquid is added in the galactosamine for fermentation, through fermentation, an acetylation reaction between the galactosamineand acetic anhydride can be completer, and the whole reaction process is simple and low in cost.

Description

technical field [0001] The disclosure relates to the technical field of medicinal chemistry, in particular to a preparation method of N-acetylgalactosamine. Background technique [0002] N-acetylgalactosamine plays an important role in anti-cancer and anti-cancer, but the existing production methods are relatively complicated and costly. Contents of the invention [0003] The purpose of the present disclosure is to provide a method for preparing N-acetylgalactosamine to achieve the purpose of producing N-acetylgalactosamine at low cost. [0004] The above-mentioned technical purpose of the present disclosure is achieved through the following technical solutions: [0005] A preparation method of N-acetylgalactosamine, comprising: [0006] S1: neutralize galactosamine hydrochloride with an acid binding agent composed of ethanol and sodium ethoxide, and desalt to obtain galactosamine; [0007] S3: adding chitinase liquid to the galactosamine for fermentation; [0008] S2:...

Claims

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Application Information

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IPC IPC(8): C07H15/12C07H1/00C12P19/26
CPCC07H1/00C07H15/12C12P19/26
Inventor 陈建国张国品
Owner 南京博源医药科技有限公司
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