Application of isoglycyrrhizin to preparation of antianxiety drugs
An isoliquiritigenin and anti-anxiety technology, which is applied in the field of medicine, can solve the problem of anti-anxiety that has not been seen with isoliquiritigenin, and achieve the effects of inhibiting occurrence and/or development, avoiding damage, and improving anxiety
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[0020] The present invention will be further illustrated in detail below in conjunction with specific embodiments. It should be noted that the descriptions of these embodiments are used to help understanding of the present invention, but are not intended to limit the present invention.
[0021] (1) Experimental animals: AD animal models are conditional PS1 / PS2 double knockout (PS1 / PS2 conditional double knockout, PS cDKO) mice, referred to as PS cDKO mice, with genotypes of Cre+ / -, PS1f / f, PS2- / - are PS cDKO mice; genotypes Cre+ / -, PS1+ / +, PS2+ / + are wild-type control mice, and the animals have free access to food and water, kept at room temperature 21±2°C, humidity (45 %~65%) and alternating light and dark (12h︰12h) environment. All experimental animal operations complied with the regulations of experimental animal ethics and biomedical ethics review methods.
[0022] (2) Drugs: Isoliquiritigenin (ISL) was purchased from Shanghai Tongtian Biology, product number: 1601262, M...
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