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Pharmacokinetics and elimination detection method of sodium ceftiofur in chicken body

A technology of ceftiofur sodium and pharmacokinetics, which is applied in the field of medicine and can solve problems such as no pharmacokinetic research reports

Inactive Publication Date: 2019-11-05
WENS FOOD GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many studies on the pharmacokinetics of this drug on large animals and waterfowl, and there is no relevant research report on the pharmacokinetics of the drug in young yellow chickens

Method used

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  • Pharmacokinetics and elimination detection method of sodium ceftiofur in chicken body
  • Pharmacokinetics and elimination detection method of sodium ceftiofur in chicken body
  • Pharmacokinetics and elimination detection method of sodium ceftiofur in chicken body

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0047] A kind of pharmacokinetics and elimination detection method of ceftiofur sodium in chicken, comprises the steps:

[0048] S1. Select 265 1-day-old yellow chickens, all of which are roosters, and randomly divide all the chickens into 4 groups of experimental groups and 1 group of control groups, wherein the experimental group has 65 chickens in each group, and inject 0.1 mg of cephalosporin into each yellow chicken Thiofur sodium, blood was collected after 5min, 15min, 30min, 45min, 1h, 2h, 4h, 8h, 12h, 24h, 36h, 48h and 72h, respectively, and 1 mL of blood was collected from each heart of 5 chicks randomly at each time point. Put in a heparinized centrifuge tube, mix well, centrifuge at 3000r / min for 10min, separate plasma and store at -20°C for later use. Five rats in the control group were injected with the same amount of normal saline, and blood was collected and plasma was separated by the same method.

[0049] S2. Perform chromatographic analysis on the heart bloo...

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Abstract

The invention discloses a pharmacokinetics and elimination detection method of sodium ceftiofur in chicken body. The method comprises the following steps: for the pharmacokinetics characteristics of four sodium ceftiofur products for injection in the yellow chicken body in one-day old, selecting a health chick in the one-day old for each medicine, subcutaneously injecting 0.1mg of sodium ceftiofurinto each chick, detecting desfuroyl ceffiofur (DFC) concentration in plasma through a high-performance liquid chromatography, researching the pharmacokinetics of the DFC in the yellow chicken body in one-day old, thereby realizing the research of the pharmacokinetics of the sodium ceftiofur in the yellow chicken body in one-day old.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a method for detecting the pharmacokinetics and elimination of ceftiofur sodium in chickens. Background technique [0002] Ceftiofur, also known as Saidefu, is a third-generation cephalosporin antibiotic for livestock and poultry that came out in the 1980s. In 1988, the US Food and Drug Administration (FDA) approved ceftiofur sodium for the treatment of bovine respiratory bacterial diseases. Because of its broad antibacterial spectrum, strong antibacterial activity, good stability to gastric acid and β-lactamase, long-lasting drug effect and less residue, ceftiofur has been widely recognized and used in the world. It is officially approved by the country and Japan for the treatment of respiratory diseases in 1-day-old chickens, turkeys, beef cattle, dairy cows, sheep, pigs, and horses. [0003] Ceftiofur sodium is a cephalosporin-type veterinary clinical antibiotic. There are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06
CPCG01N30/02G01N30/06G01N2030/027G01N2030/062
Inventor 李川川吴志玲覃健萍鲁俊鹏王占新张桂君
Owner WENS FOOD GRP CO LTD
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