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Preparation technology of ceftiofur sodium for injection, capable of preventing products from being unloaded

A technology of ceftiofur sodium and preparation process, applied in the field of medicine, can solve problems such as inability to control products, inability to monitor the preparation process, etc., and achieve the effects of less harsh reaction conditions, avoiding unlabeled, and mild reaction conditions

Inactive Publication Date: 2016-03-09
CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a preparation process of ceftiofur sodium for injection that avoids the product being unloaded, so as to overcome the fact that the existing ceftiofur sodium preparation cannot monitor the preparation process in real time during the preparation process. The issue of effective product management and control

Method used

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  • Preparation technology of ceftiofur sodium for injection, capable of preventing products from being unloaded

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Such as figure 1 Shown, avoid the preparation technology of the ceftiofur sodium for injection of empty product, comprise the following steps:

[0026] 1) Synthesis of ceftiofur sodium: use 7-aminocephalosporanic acid as the raw material, use tetrahydrofuran and purified water as the solvent in a ratio of 1:3, and obtain the triethylamine salt of ceftiofur after reaction, and then in tetrahydrofuran After reacting with sodium isooctanoate, the precipitate of ceftiofur sodium is obtained, the ratio of tetrahydrofuran to sodium isooctanoate is 2:1, the precipitate is washed with ethanol, and the wet product of ceftiofur sodium is obtained after filtration under reduced pressure;

[0027] 2), drying and grinding the prepared ceftiofur sodium wet product into powder;

[0028] 3) The preparation process of ceftiofur sodium: first clean the reagent bottle used to hold the ceftiofur sodium powder, then quantitatively fill the ceftiofur sodium powder into the above cleaned rea...

Embodiment 2

[0031] Such as figure 1 Shown, avoid the preparation technology of the ceftiofur sodium for injection of empty product, comprise the following steps:

[0032] 1) Synthesis of ceftiofur sodium: 7-aminocephalosporanic acid is used as raw material, tetrahydrofuran and purified water are used as solvents in a ratio of 1:4, and the triethylamine salt of ceftiofur is obtained through reaction, and then in tetrahydrofuran After reacting with sodium isooctanoate, the precipitate of ceftiofur sodium is obtained, the ratio of tetrahydrofuran to sodium isooctanoate is 3:1, the precipitate is washed with n-propanol, and the wet product of ceftiofur sodium is obtained after filtration under reduced pressure;

[0033] 2), drying and grinding the prepared ceftiofur sodium wet product into powder;

[0034] 3) The preparation process of ceftiofur sodium: first clean the reagent bottle used to hold the ceftiofur sodium powder, then quantitatively fill the ceftiofur sodium powder into the above...

Embodiment 3

[0037] Such as figure 1 Shown, avoid the preparation technology of the ceftiofur sodium for injection of empty product, comprise the following steps:

[0038] 1) Synthesis of ceftiofur sodium: use 7-aminocephalosporanic acid as the raw material, use tetrahydrofuran and purified water as the solvent in a ratio of 1:5, react to obtain the triethylamine salt of ceftiofur, and then dissolve it in methanol After reacting with sodium 2-ethylhexanoate, the precipitate of ceftiofur sodium is obtained, the ratio of methanol to sodium isooctanoate is 2:1, the precipitate is washed with ethylene glycol, and then filtered under reduced pressure to obtain the wet product of ceftiofur sodium;

[0039] 2), drying and grinding the prepared ceftiofur sodium wet product into powder;

[0040] 3) The preparation process of ceftiofur sodium: first clean the reagent bottle used to hold the ceftiofur sodium powder, then quantitatively fill the ceftiofur sodium powder into the above cleaned reagent ...

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Abstract

The invention relates to a preparation technology of ceftiofur sodium for injection, capable of preventing products from being unloaded. The preparation technology comprises the following steps of synthesizing the ceftiofur sodium: using 7- aminocephalosporanic acid as raw materials, performing a reaction so as to obtain triethanolamine salt of ceftiofur, and after the rriethanolamine salt reacts with sodium salt in methanol or tetrahydrofuran, obtaining precipitation of the ceftiofur sodium; drying prepared wet ceftiofur sodium products, and grinding the dried ceftiofur sodium products into powder. The preparation technology of the ceftiofur sodium comprises the following steps of firstly cleaning a reagent bottle for loading the ceftiofur sodium powder, then loading the ceftiofur sodium powder in the cleaned reagent bottle in a quantitative manner according to the specification, filling nitrogen in the reagent bottle, and then covering a pretreated rubber plug; performing cover pricking treatment by using an aluminum cover, so that products are sealed, and then sequentially pasting internal labels, packaging and lamp inspection on the reagent bottle after cover pricking treatment is performed; and then, pasting external labels on a packing box, and performing inspection and package. According to the preparation technology disclosed by the invention, the problems that in the preparation technology of the ceftiofur sodium, a preparation process cannot be monitored in real time, and the products cannot be effectively managed and controlled are solved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation process of ceftiofur sodium for injection which avoids empty loading of the product. Background technique [0002] With the development of modern animal husbandry, the long-term abuse of antibiotics in the past has caused more and more drug resistance and drug residues in many bacteria, which has attracted more and more attention. In particular, the large-scale outbreak of bird flu in recent years has caused the entire pharmaceutical industry to think deeply about medication. [0003] Ceftiofur sodium chemical name: [6R-[6α,7β(Z)]]-7-[[(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[ (2-Furancarbonyl)thio]methyl]-8oxo-5-thia-1-aminobicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt, the product is white to grayish yellow Powder, this product is a compound preparation for sterilization, anti-inflammation, antipyretic and analgesia. Ceftiofur sodium is a th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D501/36C07D501/06
CPCC07D501/36C07D501/06
Inventor 廖成斌卢朝成
Owner CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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