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Immunostimulatory injection for livestock

An immune activation and injection technology, applied in the field of injection, can solve the problems of pH value change, inconvenient use, short storage time, etc., and achieve the effects of low cost control, enhanced bactericidal function, and less toxic and side effects

Inactive Publication Date: 2012-10-17
金河牧星(重庆)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This is inconvenient to use
[0003] In addition, physiological saline for injection and glucose injection have simple ingredients and many manufacturers, and there are many problems in quality such as bacterial contamination, pH value changes, and short storage time.

Method used

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  • Immunostimulatory injection for livestock
  • Immunostimulatory injection for livestock
  • Immunostimulatory injection for livestock

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Immune activation injection (1ml is equivalent to 0.4g of the original drug)

[0027] 1. Formula

[0028] Astragalus 20g, Bupleurum 10g, tangerine peel 10g, pH regulator 0.2g, activated carbon 0.2g, PEG400 dosage 40ml, benzyl alcohol 1ml, water for injection to 100ml.

[0029] 2: Preparation method

[0030] Step 1: Take the prescription amount of astragalus and tangerine peel, slice them, add 5 times the weight of water for injection and decoct twice, the first time for 2 hours, the second time for 1 hour, combine the decoction, filter, and concentrate the filtrate to twice the amount of traditional Chinese medicine When it is cooled to 40°C, slowly add ethanol to make the alcohol content reach 75%, stir well, let it stand for 12 hours, filter the supernatant, add an appropriate amount of 75% ethanol to the residue, stir well, let stand for 12 hours , filtered, combined the ethanol solution, recovered the ethanol until it had no alcohol smell, and prepared A solution ...

Embodiment 2

[0034] Immune activation injection (1ml is equivalent to 0.3g of the original drug)

[0035] 1. Formula

[0036] Astragalus 15g, Bupleurum 7.5g, tangerine peel 7.5g, pH regulator 0.2g, activated carbon 0.15g, PEG400 30ml, benzyl alcohol 1ml, water for injection to 100ml.

[0037] 2: Preparation method: the same as the method described in Example 1.

Embodiment 3

[0039] Immune activation injection (1ml is equivalent to 0.2g of the original drug)

[0040] 1. Formula

[0041] Astragalus 10g, Bupleurum 5g, tangerine peel 5g, pH regulator 0.1g, activated carbon 0.1g, PEG400 20ml, benzyl alcohol 1ml, water for injection to 100ml.

[0042] 2: Preparation method: the same as the method described in Example 1.

[0043] 1. Accelerated stability test of immune activation injection

[0044] 1. Materials and methods: Take the immune activation injection of Example 1-3, and carry out high-temperature, high-humidity, and strong-light acceleration experiments according to the drug stability test method in the first appendix of the "Chinese Veterinary Pharmacopoeia" 2010 edition, according to commercially available packaging, at a temperature of 40 Place in a drug stability test box (Chongqing Yongsheng Experimental Instrument Factory) at ±2°C, relative humidity 75±5%, and illuminance 4500±500LX for 6 months, and take samples at the end of the first...

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PUM

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Abstract

The invention relates to an immunostimulatory injection for livestock. The injection can be used as a diluent to enhance immune effects of vaccine especially serum and strongly enhance the antibacterial efficacy of the antibiotic powder injection; and the injection can be individually used to protect liver, promote bile flow, bring down a fever and improve the growth performance of animal bodies. The invention is characterized in that immunostimulatory injection is prepared by the following steps of: taking 10-20 g of Radix Astragali and 5-10 g of dried orange peel, slicing, decocting, concentrating by the use of ethanol to prepare a liquid A for standby; cutting off 5-10 g of radix bupleuri, adding water and distilling, dissolving by adding PEG 400 so as to prepare a liquid B for standby; adding the liquid B into the liquid A, adding injection water to 85-95 ml, using a pH conditioning agent, adding 0.1-0.2 g of active carbon, slightly boiling for 1 h, standing until it cools, adding 1 ml of benzyl alcohol for a constant volume of 100 ml; filtering, embedding, and sterilizing. The injection is produced at low cost, has good effect when singly used or used as a diluent, and especially has substantial synergism for ceftiofur sodium.

Description

technical field [0001] The invention relates to an injection, especially an injection that can be used as a diluent for injection or used for injection alone. Background technique [0002] In the prevention and treatment of livestock and poultry diseases, various types of freeze-dried vaccine preparations and powdered powder injection preparations are used, which need to be diluted in proportion before injection or drip in clinical use. At present, there are two kinds of diluents commonly used by veterinarians, physiological saline for injection and glucose injection, and they all have insufficient functions. Glucose injection can provide energy to the animal body while diluting the drug, but its pH value is about 3.0, which is far lower than the optimal pH (pH=7-8) of diluted vaccines and most antibiotic powder injections. Salt water has a slightly higher pH of 4-5, which is also less than optimal for use and does not provide energy. So much so that in clinical use, some ...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K39/39A61K9/08A61P31/04A61P37/04A61P1/16A61P29/00A61P39/00
Inventor 陈益德秦斌胡学全
Owner 金河牧星(重庆)生物科技有限公司
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