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Natural medicine preparation for preventing and treating atherosclerosis by regulating intestinal flora balance

A technology for atherosclerosis and regulation of intestinal flora, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve chronic problems, inappropriate resistance, etc., and save time , high extraction rate and transfer rate, remarkable effect

Active Publication Date: 2019-11-26
JIYANG COLLEGE OF ZHEJIANG A & F UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While acute inflammation is beneficial, chronic inflammation can become problematic and inappropriately against the body's own tissues

Method used

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  • Natural medicine preparation for preventing and treating atherosclerosis by regulating intestinal flora balance
  • Natural medicine preparation for preventing and treating atherosclerosis by regulating intestinal flora balance
  • Natural medicine preparation for preventing and treating atherosclerosis by regulating intestinal flora balance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046]1. The preparation method of the described black corncob anthocyanin extraction and purification is as follows: the low-temperature air-dried black corncob is placed in a tissue crushing extractor, and the solid-liquid ratio is added to 50% ethanol at pH 3.0 of 1:6 The solution was crushed and extracted at room temperature for 2 min. Suction filtration, the resulting filter residue was added to a 50% ethanol solution with a solid-to-liquid ratio of 1:5 and pH 3.0, and ultrasonic extraction was used instead of ultrasonic extraction at room temperature for 1 time, extraction for 40 minutes, and suction filtration. The tissue fragmentation extract and the ultrasonic extract were combined, and concentrated by flash evaporation at 40°C to 1 / 6 of the original volume to obtain a concentrate. The concentrated solution was enriched and purified by macroporous adsorption resin Diaion HP 2MGL column chromatography for total anthocyanins. Rinse with distilled water until the eluent...

Embodiment 2

[0051] 1. The preparation method of the described black corncob anthocyanin extraction and purification is as follows: the low-temperature air-dried black corncob is placed in a tissue crushing extractor, and the solid-liquid ratio is 1:4 by adding 55% ethanol of pH 3.0 The solution was crushed and extracted at room temperature for 2 min. Suction filtration, the resulting filter residue was added to a 55% ethanol solution with a solid-to-liquid ratio of 1:3 and pH 3.0, and ultrasonic extraction was used instead of ultrasonic extraction at room temperature for 1 time, extraction for 30 minutes, and suction filtration. The tissue crushing extract and the ultrasonic extract were combined, flash-concentrated at 45°C to 1 / 5 of the original volume to obtain a concentrate. The concentrated solution was enriched and purified by macroporous adsorption resin Diaion HP 2MGL column chromatography for total anthocyanins. Rinse with distilled water until the eluate is colorless and transpa...

Embodiment 3

[0056] 1. The preparation method of the described black corncob anthocyanin extraction and purification is as follows: the low-temperature air-dried black corncob is placed in a tissue crushing extractor, and the solid-liquid ratio is 1:5 by adding 50% ethanol with a pH of 3.0 The solution was crushed and extracted at room temperature for 2 min. Suction filtration, the resulting filter residue was added to a 55% ethanol solution with a solid-to-liquid ratio of 1:4 and pH 3.0, and ultrasonic extraction was used instead of ultrasonic extraction at room temperature for 1 time, extracted for 35 minutes, and suction filtered. The tissue crushing extract and the ultrasonic extract were combined, flash-concentrated at 50°C to 1 / 5 of the original volume to obtain a concentrate. The concentrated solution was enriched and purified by macroporous adsorption resin Diaion HP 2MGL column chromatography for total anthocyanins. Rinse with distilled water until the eluate is colorless and tra...

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Abstract

The invention provides a natural medicine preparation for preventing and treating atherosclerosis by regulating intestinal flora balance, and belongs to the technical field of Chinese medicine research. The natural medicine preparation is prepared from the following components in percentage by weight: 40-50% of a black corncob anthocyanin extract purified product, 10-25% of a mimosa pudica total flavone extract purified product, 20-30% of a Chinese loropetalum leaf tannin extract purified product, and 10-20% of curcumin. According to the technical scheme, the natural medicine preparation for preventing and treating atherosclerosis by regulating intestinal flora balance is reasonable in formula, environmentally friendly, good in safety, and suitable for long-term administration; through synergistic enhancement of all ingredients and components, the obvious treating effect on atherosclerosis rats is achieved; through the special composition, the natural medicine preparation has the significant effect on treating atherosclerosis, and is convenient to take; and meanwhile, main raw materials, namely black corncobs, adopted by the natural medicine preparation are plant waste, raw material sources are rich, the waste is turned into treasure, and the reutilization rate of the resources is increased.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine research, in particular to a natural medicine preparation for preventing and treating atherosclerosis by regulating the balance of intestinal flora. Background technique [0002] Atherosclerosis is the pathological basis of cardiovascular and cerebrovascular diseases. According to surveys, the mortality rate of cardiovascular and cerebrovascular diseases in my country has surpassed that of tumors, becoming the number one killer of health hazards. With the continuous improvement of people's living standards, high-fat, high-sugar, high-calorie diets cause a series of metabolic diseases, such as hypertension, hyperlipidemia, diabetes, obesity, fatty liver, cardiovascular and cerebrovascular diseases, etc. According to the survey, metabolic diseases The morbidity and mortality of vascular diseases caused by diseases, especially hyperlipidemia, are increasing year by year, and the...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61K36/48A61P9/10A61K31/353A61K31/12
CPCA61K36/899A61K31/353A61K36/48A61K36/185A61K31/12A61P9/10A61K2236/333A61K2236/39A61K2236/55A61K2236/33A61K2300/00
Inventor 袁珂罗阳方继莉
Owner JIYANG COLLEGE OF ZHEJIANG A & F UNIV
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