Application of zingiber strioatum volatile oil to preparation of anti-prostatic-cancer products

A technology for anti-prostate cancer and prostate cancer, which is applied in the application field of anchovy volatile oil in the preparation of anti-prostate cancer products, and can solve the problems of the undisclosed application of anchovy volatile oil extract and the absence of clearly given anti-tumor effect extract components, etc.

Inactive Publication Date: 2019-12-03
GUANGDONG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the one hand, this extraction method does not clearly specify the extract components with anti-tumor effects; on the other hand, the tumors disclosed in the test are only human liver cancer cells HepG2, human fibrosarcoma cells HT-1080, human colon cancer cells

Method used

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  • Application of zingiber strioatum volatile oil to preparation of anti-prostatic-cancer products
  • Application of zingiber strioatum volatile oil to preparation of anti-prostatic-cancer products
  • Application of zingiber strioatum volatile oil to preparation of anti-prostatic-cancer products

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The application of the volatile oil of sunflower in the preparation of anti-prostate cancer products, the volatile oil of sunflower is the volatile oil of sunflower.

[0039] Wherein the preparation method of Yanghe Huahua volatile oil is as follows:

[0040] Take 1000g of fresh yang lotus flower, after being crushed by a wall breaking machine, the yang lotus flower sample to be extracted is obtained;

[0041] Transfer the Yanghe flower sample to be extracted to a 10L round-bottomed flask, add 6L deionized water, connect the volatile oil extraction device, extract by steam distillation for 4 hours, and repeat the extraction three times;

[0042]Collect the obtained volatile oil samples, extract with n-hexane, add anhydrous sodium sulfate to remove water, and then pass through a filter membrane with a pore size of 0.22 μm.

Embodiment 2

[0044] The application of the volatile oil of sunflower root in the preparation of anti-prostate cancer products, wherein the volatile oil of sunflower root is the volatile oil of sunflower root.

[0045] Wherein the preparation method of the volatile oil of Yanghe volatile root is as follows:

[0046] Take 1,000 g of fresh Cinnamomum sinensis root, place it in an oven at 37°C to dry the water, pulverize it with a pulverizer, and pass it through a 60-mesh sieve to obtain a Cinnamomum sinensis root sample to be extracted;

[0047] Transfer the sample of the root of the lotus root to be extracted to a 10L round bottom flask, add 6L of deionized water, connect the volatile oil extraction device, extract by steam distillation for 4 hours, and repeat the extraction three times;

[0048] Collect the obtained volatile oil samples, extract with n-hexane, add anhydrous sodium sulfate to remove water, and then pass through a filter membrane with a pore size of 0.22 μm.

[0049] (1) ide...

Embodiment 3

[0065] An application of sunflower volatile oil in the preparation of anti-prostate cancer products. The sunflower volatile oil is the sunflower volatile oil, and the active ingredients of the sunflower volatile oil are: β-phellandrene, β-pinene, α-humulene, α- pinene, cryptopinone, β-elemene and β-myrcene, prostate cancer is prostate cancer caused by LNCaP lesions, and the concentration of the volatile oil of sunflower in the product is 30 μg / mL.

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Abstract

The invention discloses application of zingiber strioatum volatile oil to preparation of anti-prostatic-cancer products and provides the application of the zingiber strioatum volatile oil to preparation of the anti-prostatic-cancer products. The zingiber strioatum volatile oil is especially suitable for the prostatic cancer caused by LNCaP and/or PC-3 cell pathological change; the IC50 of zingiberstrioatum flour volatile oil to LNCaP is 55.75 ug/mL, and the IC50 of the zingiber strioatum flour volatile oil to the PC-3 is 77.17 ug/mL; and the IC50 of zingiber strioatum root cynomorium songaricum volatile oil to LNCaP is 91.37 ug/mL, and the IC50 of the zingiber strioatum root volatile oil to the PC-3 is 36.68 ug/mL. The zingiber strioatum flour volatile oil comprises the main components ofbeta-phellandrene, beta-pinene, alpha-humulene, alpha-pinene, cryptone, beta-elemene and beta-myrcene. The zingiber strioatum root volatile oil comprises the main components of (E,E)-geranyl linalool, beta-phellandrene, beta-pinene, alpha-humulene, beta-humulene and isolongifolol. The zingiber strioatum volatile oil has a very good inhibition effect on the migration of LNCaP and PC-3 cells.

Description

technical field [0001] The invention relates to the technical field of preparation of anti-prostate cancer drugs, and more specifically relates to the application of a sunflower volatile oil in the preparation of anti-prostate cancer products. Background technique [0002] Cancer is a disease in which one of the most important features is the uncontrolled proliferation of cells in the body. Currently, cancer is the second leading cause of morbidity and mortality worldwide, with 9.6 million cancer-related deaths in 2018, according to the World Health Organization. Worldwide, prostate cancer is the second most common cancer and the fifth leading cause of cancer-related death in men. Prostate cancer is statistically more common in developed countries, but prevalence is increasing in developing countries. In the United States, there were an estimated 164,690 new cases and 29,430 deaths from prostate cancer in 2018. According to the latest information released by the National ...

Claims

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Application Information

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IPC IPC(8): A61K36/9068A61P35/00
CPCA61K36/9068A61P35/00
Inventor 黄泽彬郑希王华威钟家本李彦辰林芷晴张蓝月张焜
Owner GUANGDONG UNIV OF TECH
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