A preparation method of natural copper/drynaria rhizome compound brushite

A technology of compound calcium phosphate stone and drynaria is applied in the direction of prosthesis, tissue regeneration, medical science, etc. It can solve the problems of short half-life, aggravate the patient's economic burden and high price, and achieve the effect of maintaining stable release.

Active Publication Date: 2021-11-09
HENAN UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these active biomolecules are very expensive, and at the same time have a short half-life and are easy to dissociate, which requires high preparation technology for composite materials, and the material has a short shelf life, which increases the production cost of materials and increases the economic burden of patients in clinical use.

Method used

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  • A preparation method of natural copper/drynaria rhizome compound brushite
  • A preparation method of natural copper/drynaria rhizome compound brushite
  • A preparation method of natural copper/drynaria rhizome compound brushite

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Embodiment 1

[0026] A preparation method of natural copper / drynaria rhizome compound brushite, comprising the steps of:

[0027] Step 1. Weigh and sieve 200-mesh β-calcium phosphate powder and calcium phosphate monohydrate powder according to the molar ratio of 1.1:1, put them into a mortar, and grind for 15 minutes to obtain mixed powder A1;

[0028] Step two, prepare 1.5wt% sodium alginate solution, 2wt% CaCl 2 solution and 0.5M citric acid solution containing 1 wt% chitosan, select the drynaria extract and grind it into powder, add it to the sodium alginate solution, stir it evenly, extract it with a syringe and add CaCl dropwise 2 In the solution, microspheres were formed and cross-linked for 4 hours. The microspheres were washed with deionized water, soaked in citric acid solution, washed with deionized water again, and pre-frozen at -80°C for 24 hours. Freeze-dried for 6 hours to obtain calcium alginate microspheres loaded with 3wt% Rhizoma Drynariae extract, powder A1 was added cal...

Embodiment 2

[0032] A preparation method of natural copper / drynaria rhizome compound brushite, comprising the steps of:

[0033] Step 1. Weigh and sieve 200-mesh β-calcium phosphate powder and calcium phosphate monohydrate powder according to the molar ratio of 1.1:1, put them into a mortar, and grind for 15 minutes to obtain mixed powder A1;

[0034] Step 2, prepare 2wt% sodium alginate solution, 4wt% CaCl 2 solution and 0.5M citric acid solution containing 1 wt% chitosan, select the drynaria extract and grind it into powder, add it to the sodium alginate solution, stir it evenly, extract it with a syringe and add CaCl dropwise 2 In the solution, microspheres were formed and cross-linked for 4 hours. The microspheres were washed with deionized water, soaked in citric acid solution, washed with deionized water again, and pre-frozen at -80°C for 24 hours. Freeze-dried for 6 hours to obtain calcium alginate microspheres loaded with 3wt% Rhizoma Drynariae extract, add calcium alginate micros...

Embodiment 3

[0038] A preparation method of natural copper / drynaria rhizome compound brushite, comprising the steps of:

[0039] Step 1. Weigh and sieve 200-mesh β-calcium phosphate powder and calcium phosphate monohydrate powder according to the molar ratio of 1.1:1, put them into a mortar, and grind for 15 minutes to obtain mixed powder A1;

[0040] Step 2: Prepare 2.5wt% sodium alginate solution, 6 wt% CaCl 2solution and 0.5M citric acid solution containing 1 wt% chitosan, select the drynaria extract and grind it into powder, add it to the sodium alginate solution, stir it evenly, extract it with a syringe and add CaCl dropwise 2 In the solution, microspheres were formed and cross-linked for 4 hours. The microspheres were washed with deionized water, soaked in citric acid solution, washed with deionized water again, and pre-frozen at -80°C for 24 hours. Freeze-dried for 6 hours to obtain calcium alginate microspheres loaded with 3wt% Rhizoma Drynariae extract, add calcium alginate micr...

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Abstract

A preparation method of natural copper / drynaria rhizome compound brushite, the specific method is as follows: take β-calcium phosphate powder and calcium phosphate monohydrate powder according to the molar ratio of 1.1:1, grind to obtain mixed powder A1, add Calcium alginate microspheres loaded with 3wt% Rhizoma Drynaria extract were ground to obtain mixed powder A2, weighed vinegar-calcined natural copper and triple-distilled water in a ratio of 1:2, simmered until the ratio was 11:1, and filtered to obtain Filtrate B: Add filtrate B to mixed powder A2 at a ratio of 2.5:1, mix to obtain a uniform paste, fill the paste into a mold, and take it out after curing to obtain a composite material. Compared with drugs loaded with growth factors, the present invention has lower price, simple and easy-to-obtain raw materials, stable drug effect, and is suitable for large-scale production. The non-expansion feature makes the material system of composite microspheres more stable.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of natural copper / drynaria drynaria compound brushite. Background technique [0002] Natural copper has a long history as a medicine for bone healing in our country. According to the statistics of the "Dictionary of Traditional Chinese Medicine Prescriptions", among the 117 prescriptions titled with the word "Jiangu" in the past dynasties, 43 of them used natural copper, accounting for 36.8%. Studies have shown that natural copper is a ferrous mineral pyrite, rich in iron, which is beneficial to the formation of collagen in the early callus of fracture healing, and can also promote the calcification of callus in the middle and late stages. At the same time, natural copper also contains a variety of trace elements necessary for the human body such as copper, zinc, and manganese, which can enhance the activity of various enzymes, promote the for...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/20A61L27/02A61L27/12A61L27/50A61L27/54A61L27/56
CPCA61L27/025A61L27/12A61L27/20A61L27/3637A61L27/50A61L27/54A61L27/56A61L2300/102A61L2300/30A61L2300/412A61L2430/02C08L5/04
Inventor 赵三团裴正军李光大张开丽商文超李朋斌翟江波景爱华李景华
Owner HENAN UNIV OF SCI & TECH
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