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Bioreactor virus infected cell quality evaluation method

A bioreactor, virus infection technology, applied in the direction of instruments, image data processing, calculation, etc., can solve problems such as empirical evaluation errors, inability to quantitative analysis, etc., to achieve the effect of solving large errors

Active Publication Date: 2020-02-28
CHANGCHUN UNIV OF SCI & TECH
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Problems solved by technology

Subjective evaluation and empirical evaluation have large errors, and cannot be quantitatively analyzed

Method used

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  • Bioreactor virus infected cell quality evaluation method
  • Bioreactor virus infected cell quality evaluation method
  • Bioreactor virus infected cell quality evaluation method

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Embodiment Construction

[0019] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0020] The invention provides a method for evaluating the quality of virus-infected cells in a bioreactor. The general flow of the method is as follows: firstly, the visual salience GBVS model is used to distinguish the characteristics of the local area of ​​the image according to the three characteristics of the image color, brightness, and direction of the infected cell, and the image is calculated. Then a two-dimensional maximum entropy algorithm is proposed...

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Abstract

The invention discloses a bioreactor virus infected cell quality evaluation method and relates to the technical field of bioreactors, and the method comprises saliency map calculation, saliency map segmentation, connected region marking and infected cell marking. A saliency method is applied to infection quality evaluation for the first time, realizes objective evaluation of virus infected cell states, and solves the problems that errors of subjective evaluation and experience evaluation are large and quantitative analysis cannot be performed.

Description

technical field [0001] The invention relates to the technical field of bioreactors, in particular to a method for evaluating the quality of virus-infected cells in bioreactors. Background technique [0002] A bioreactor is a device that achieves in vitro culture by simulating the in vivo growth environment of enzymes or organisms (such as cells, microorganisms, etc.) through biological reactions or self-metabolism. Bioreactors play an important role in vaccine production, monoclonal antibody preparation, pharmaceutical production, tumor prevention and treatment, wine making, biological fermentation, and degradation of organic pollutants. [0003] In the field of biopharmaceuticals, a large part of the application of bioreactors to cultivate cells is to serve as carriers for virus proliferation, and it is difficult to automatically evaluate the state of virus-infected cells in the context of normal cells. At present, people's subjective visual evaluation is used or the infec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06T7/00G06T7/11G06T7/136G06T7/187G06T7/62
CPCG06T7/0012G06T7/11G06T7/136G06T7/187G06T7/62G06T2207/30004Y02P90/30
Inventor 宫平李清亮马辰昊郭红壮葛辉琼张宁阚宝慧朱海焕吴昊李旭吉翔宇谭国桢
Owner CHANGCHUN UNIV OF SCI & TECH
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