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Application of SNORD16 gene in preparation of colon cancer detection kits and related kits

A detection kit, a technology for colon cancer, applied in the biological field, can solve problems such as decreased mortality

Active Publication Date: 2020-05-08
ACADEMY OF MILITARY MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Colon cancer-related mortality has declined significantly over the past few decades due to improvements in cancer prevention, early diagnosis, and treatment, but there is still room to improve overall outcomes for colon cancer patients

Method used

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  • Application of SNORD16 gene in preparation of colon cancer detection kits and related kits
  • Application of SNORD16 gene in preparation of colon cancer detection kits and related kits
  • Application of SNORD16 gene in preparation of colon cancer detection kits and related kits

Examples

Experimental program
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Effect test

Embodiment 1

[0022] Example 1. Study on the correlation between SNORD16 gene and pathological parameters of colon cancer.

[0023] 1. Patients and tissue samples

[0024] This study analyzed 434 colon cancer patients from The Cancer Genome Atlas (TCGA) database. When evaluating the relationship between SNORD16 expression and clinicopathological parameters, patients with incomplete clinical data were excluded from the study, a total of 279 cases. Complete clinical information includes: patient's gender, age, TNM stage, pathological T stage, lymph node metastasis, distant metastasis, lymphatic invasion, venous invasion, and history of colonic polyps. In addition, 20 pairs of matched colon cancer and adjacent normal mucosal tissues were obtained from the Department of Colorectal Surgery, Cancer Hospital Affiliated to China Medical University, for the evaluation of SNORD16 expression. The ethics committee approved the use of the specimens, and informed consent was obtained from each patient....

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Abstract

The invention provides an application of an SNORD16 gene in preparation of colon cancer detection kits and the related kits, and belongs to the technical field of biology. In order to mine prognosticbiomarkers for identifying high-risk patients and explore a novel molecular mechanism of colon cancer pathogenesis, the invention provides the application of the SNORD16 gene in the preparation of thecolon cancer detection kits, wherein the nucleotide sequence of the SNORD16 gene is shown in SEQ ID No.1. The kits are used for colon cancer diagnosis and / or prognosis assessment; compared with normal tissue adjacent to cancers, the SNORD16 gene is highly expressed in colon cancer cells or tissue. The invention also provides the related detection kits. In-vitro functional experiments show that the SNORD16 can promote growth, proliferation, migration and invasion of the colon cancer cells by inhibiting apoptosis, and indicate that the SNORD16 has carcinogenic effects in colon cancer and can beused as the novel diagnostic and prognostic biomarker for the colon cancer.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to the application of SNORD16 gene in the preparation of a colon cancer detection kit and related kits. Background technique [0002] Colon cancer is considered to be one of the most common and deadly malignancies in both men and women. Its widespread existence requires novel diagnostic and prognostic biomarkers. [0003] Colon cancer-related mortality has declined significantly over the past few decades due to improvements in cancer prevention, early diagnosis, and treatment, but there is still room to improve the overall prognosis of colon cancer patients. To this end, there is an urgent need to explore new prognostic biomarkers that can identify high-risk patients as well as novel molecular mechanisms of colon cancer pathogenesis. Emerging evidence suggests that small nucleolar RNAs (snoRNAs) play key roles in tumor development. [0004] Noncoding RNAs, especially micr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/158
Inventor 王治东贺俊彦刘鑫戚振华王琪路雯清
Owner ACADEMY OF MILITARY MEDICAL SCI
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