New application of hydroxychloroquine

A technology of hydroxychloroquine and new use, applied in the new use field of hydroxychloroquine, can solve the problem of no hydroxychloroquine and the like, achieve good therapeutic effect, reduce the area, and protect the liver from ischemia-reperfusion injury.

Pending Publication Date: 2020-07-24
LANZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there is no relevant research on the use of hydroxychloroquine in the treatment of liver ischemia-reperfusion injury

Method used

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  • New application of hydroxychloroquine
  • New application of hydroxychloroquine
  • New application of hydroxychloroquine

Examples

Experimental program
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Effect test

Embodiment

[0019] Eighteen SCID mice and 15 c57BL / 6 mice aged about 8-10 weeks were selected and randomly divided into sham operation group (Sham group), hydroxychloroquine treatment group (HCQ group) and ischemia-reperfusion group (I / R group) three groups. The HCQ group was given hydroxychloroquine (HCQ group) (according to the weight of the mice, 80 μg / g of hydroxychloroquine was given every day) for intragastric administration, and the Sham group and the I / R group were given intragastric administration of normal saline. Mice were used to make mouse models of ischemia-reperfusion injury, while the Sham group only underwent laparotomy without liver ischemia intervention. After completion, the levels of liver function indicators ALT and AST in the serum of the mice were detected, NETs formation-related indicators NETs and cfDNA in the serum were measured, and liver tissue was taken for HE staining and immunohistochemical staining to observe the degree of liver damage.

[0020] from fi...

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PUM

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Abstract

The present invention discloses a new application of hydroxychloroquine. The hydroxychloroquine is used for preparing medicines for treating hepatic ischemia reperfusion injury. According to the new application of the hydroxychloroquine, by inhibiting the generation of neutrophil extracellular traps (nets), the good treatment effect can be taken for the hepatic ischemia reperfusion injury, so thatthe injury area of the liver is reduced.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a new application of hydroxychloroquine. Background technique [0002] Hydroxychloroquine (Hydroxychloroquine) is a 4-aminoquinoline derivative antimalarial drug, which is suitable for malaria, allergic and autoimmune diseases. In recent years, with the advancement of shock treatment and the establishment and promotion of methods such as arterial bypass surgery, thrombolytic therapy, percutaneous transluminal coronary angioplasty, cardiac surgery extracorporeal circulation, cardiopulmonary cerebral resuscitation, severed limb replantation and organ transplantation, etc. Application, so that many tissues and organs can be reperfused with blood after ischemia. In most cases, reperfusion after ischemia can restore the function of tissues and organs, repair the damaged structure, and improve the condition of the patient; dysfunction and structural damage. This kind of tissue damage is aggr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4706A61P1/16
CPCA61K31/4706A61P1/16
Inventor 张思功李玉民
Owner LANZHOU UNIVERSITY
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