Application of SELENOF as drug target for Alzheimer's disease

A technology for Alzheimer's disease and drugs, which is applied in the field of Alzheimer's disease, and can solve problems such as inaccurate targets and affecting the treatment of Alzheimer's disease

Active Publication Date: 2020-07-28
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide an application of SELENOF as a drug target for Alzheimer's disease, aiming to solve the problem that the drug target for Alzheimer's disease in the prior art is not accurate, thereby affecting the treatment of Alzheimer's disease

Method used

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  • Application of SELENOF as drug target for Alzheimer's disease
  • Application of SELENOF as drug target for Alzheimer's disease
  • Application of SELENOF as drug target for Alzheimer's disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Seven cases of prefrontal cortex brain tissue were taken from normal people of the same sex and patients with Alzheimer's disease (AD) after death, and the content of SELENOF (selenoprotein F) was detected after tissue protein extraction, and the difference in the content of SELENOF was further analyzed.

Embodiment 2

[0034] Provide mice for further analysis and detection of BACE1, Aβ1-42, SELENOF and other indicators. The specific test steps are as follows:

[0035] (1) First, the expression and expression of SELENOF (selenoprotein F) in 1-month-old, 6-month-old, and 13-month-old mice with 3×Tg Alzheimer's disease (AD) were statistically analyzed analyze.

[0036] (2) Provide 4-month-old 3×Tg, all-female mice, 24 mice, provide the interference group (SH-AD group) of "addition of interference with selenoprotein F expression" and the control of "no addition of interference with selenoprotein F expression" group (NC-AD group).

[0037] The interference group (SH-AD group) "added to interfere with the expression of selenoprotein F" uses brain stereotaxic microinjection of shRNA adeno-associated virus AAV9 that interferes with the expression of selenoprotein F into the CA3 region of the mouse hippocampus, and interferes with hippocampal selenoprotein F. The expression of mouse SELENOF (seleno...

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Abstract

The invention provides an application of SELENOF as a target spot in Alzheimer's disease. SELENOF is used as a drug target of the Alzheimer's disease; a drug target can be provided for a drug for treating Alzheimer's disease; the expression quantity of BACE1 is reduced by up-regulating the expression of SELENOF in the brain, so that A beta is reduced to achieve an AD treatment effect; a new molecular mechanism for promoting an AD pathological process by reducing the expression of SELENOF is provided, and a new strategy and standard are provided for the treatment of Alzheimer's disease.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to an application of SELENOF as a target in Alzheimer's disease. Background technique [0002] Alzheimer's disease (AD) is one of the most common senile neurodegenerative diseases, and its clinical symptoms are mainly characterized by progressive cognitive decline, memory impairment and abnormal personality changes. The incidence of the disease is about 10% in the elderly, and it is increasing year by year, affecting more than 30 million people in the world. [0003] The pathological features of Alzheimer's disease refer to dense plaques containing amyloid β-protein (Aβ), neuronal degeneration, neurofibrillary tangles (NFT) with abnormally phosphorylated tau protein , Reduced neurons and synapses in brain tissue and other reasons. In the study of the pathogenesis of Alzheimer's disease, the pathogenic mechanism of β-amyloid polypeptide (Aβ) is recognized as the most classic pathogenic m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/68G01N2800/2821
Inventor 刘敏任冰玉唐李玮田静
Owner SHENZHEN UNIV
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