Application of a macrophage migration inhibition factor as drug target in treatment of perioperative cerebral apoplexy

A technology of mobile inhibition and macrophages, which is applied in the field of medicine to achieve the effect of improving neurobehavioral function

Inactive Publication Date: 2020-08-04
RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
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However, the role of MIF in BBB d

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  • Application of a macrophage migration inhibition factor as drug target in treatment of perioperative cerebral apoplexy
  • Application of a macrophage migration inhibition factor as drug target in treatment of perioperative cerebral apoplexy
  • Application of a macrophage migration inhibition factor as drug target in treatment of perioperative cerebral apoplexy

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Embodiment Construction

[0022] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the teachings of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

[0023] The present invention determines the sample size (power 80%, α=0.05) by performing a power calculation of the mean square deviation and standard deviation on the main parameters. Continuous data are presented as mean ± standard error (SEM). Data from two groups were analyzed using t-test. Data from three or more groups were analyzed using one-way ANOVA with a Bonferroni test for multiple comparisons. Differences in mu...

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Abstract

The invention discloses an application of a macrophage migration inhibition factor as a drug target in treatment of perioperative cerebral apoplexy. It is found for the first time that MIF-mediated endothelial cell apoptosis is a main mechanism for destroying blood-brain barrier integrity and neurological impairment after stroke after PIS, and MIF-mediated endothelial cell apoptosis is used as a drug target for treating perioperative cerebral stroke. The invention discloses a mechanism of BBB damage after cerebral apoplexy in the perioperative period and the relation between the mechanism andperipheral immune response for the first time, an innovative mechanism is found for neurological function damage of cerebral arterial thrombosis in the perioperative period, and an innovative treatment thought is provided for improving the neurobehavioral function and cognitive function of cerebral apoplexy in the perioperative period.

Description

technical field [0001] The invention belongs to the field of drugs, and relates to the application of a macrophage migration inhibitory factor as a drug target in the treatment of perioperative stroke. Background technique [0002] Perioperative ischemic stroke is a major clinical problem faced by clinical anesthesiologists. It has the characteristics of high incidence, great harm, and difficult treatment. Due to its high incidence and devastating consequences in surgical patients, it is becoming more and more Having attention. The incidence of perioperative stroke (PIS) is closely related to the type and complexity of surgical methods, and it has been reported that the incidence of PIS in postoperative patients is as high as 2.9%-4%. In addition to cardiac surgery, the incidence of perioperative stroke is also higher in general surgery with a high volume of surgery, and the risk of cognitive decline 1 year after surgery is significantly increased. [0003] The blood-brain...

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Application Information

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IPC IPC(8): A61K45/00A61P9/10
CPCA61K45/00A61P9/10
Inventor 李佩盈李妍俞卫锋黄婷婷张月蔓
Owner RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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