Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of a macrophage migration inhibition factor as drug target in treatment of perioperative cerebral apoplexy

A technology of mobile inhibition and macrophages, which is applied in the field of medicine to achieve the effect of improving neurobehavioral function

Inactive Publication Date: 2020-08-04
RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the role of MIF in BBB damage after PIS remains unreported

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of a macrophage migration inhibition factor as drug target in treatment of perioperative cerebral apoplexy
  • Application of a macrophage migration inhibition factor as drug target in treatment of perioperative cerebral apoplexy
  • Application of a macrophage migration inhibition factor as drug target in treatment of perioperative cerebral apoplexy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. In addition, it should be understood that after reading the teachings of the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

[0023] The present invention determines the sample size (power 80%, α=0.05) by performing a power calculation of the mean square deviation and standard deviation on the main parameters. Continuous data are presented as mean ± standard error (SEM). Data from two groups were analyzed using t-test. Data from three or more groups were analyzed using one-way ANOVA with a Bonferroni test for multiple comparisons. Differences in mu...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of a macrophage migration inhibition factor as a drug target in treatment of perioperative cerebral apoplexy. It is found for the first time that MIF-mediated endothelial cell apoptosis is a main mechanism for destroying blood-brain barrier integrity and neurological impairment after stroke after PIS, and MIF-mediated endothelial cell apoptosis is used as a drug target for treating perioperative cerebral stroke. The invention discloses a mechanism of BBB damage after cerebral apoplexy in the perioperative period and the relation between the mechanism andperipheral immune response for the first time, an innovative mechanism is found for neurological function damage of cerebral arterial thrombosis in the perioperative period, and an innovative treatment thought is provided for improving the neurobehavioral function and cognitive function of cerebral apoplexy in the perioperative period.

Description

technical field [0001] The invention belongs to the field of drugs, and relates to the application of a macrophage migration inhibitory factor as a drug target in the treatment of perioperative stroke. Background technique [0002] Perioperative ischemic stroke is a major clinical problem faced by clinical anesthesiologists. It has the characteristics of high incidence, great harm, and difficult treatment. Due to its high incidence and devastating consequences in surgical patients, it is becoming more and more Having attention. The incidence of perioperative stroke (PIS) is closely related to the type and complexity of surgical methods, and it has been reported that the incidence of PIS in postoperative patients is as high as 2.9%-4%. In addition to cardiac surgery, the incidence of perioperative stroke is also higher in general surgery with a high volume of surgery, and the risk of cognitive decline 1 year after surgery is significantly increased. [0003] The blood-brain...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K45/00A61P9/10
CPCA61K45/00A61P9/10
Inventor 李佩盈李妍俞卫锋黄婷婷张月蔓
Owner RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com