Method and plasma collection system capable of reducing mixing amount of leukocytes in collected plasma

A leukocyte collection technology, which is applied in blood circulation treatment, suction equipment, complex mathematical operations, etc., can solve the problem of high leukocyte incorporation, and achieve the effect of simple method, meeting requirements, and scientific design

Active Publication Date: 2020-08-14
四川天府亨特生命科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem solved by the present invention is: to provide a method and a plasma collection system that can reduce the amount of white blood cells mixed in the collected plasma, and solve the problem of excessive white blood cells mixed in the plasma in the prior art

Method used

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  • Method and plasma collection system capable of reducing mixing amount of leukocytes in collected plasma
  • Method and plasma collection system capable of reducing mixing amount of leukocytes in collected plasma
  • Method and plasma collection system capable of reducing mixing amount of leukocytes in collected plasma

Examples

Experimental program
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Effect test

Embodiment 1

[0036] as attached figure 2 As shown, a kind of blood plasma collection system that can reduce leukocyte mixing amount in the collection plasma of the present invention, it comprises:

[0037] Calculation module, used to calculate the amount of plasma collected per cycle P according to the input blood HCT S ;

[0038] A centrifuge device for centrifuging whole blood to collect its plasma components;

[0039] A blood pump, connected from the whole blood source and connected to the centrifuge device, is used to drive the whole blood in the whole blood source into the centrifuge device;

[0040] The plasma weight monitor is set on the centrifuge device and is used for real-time monitoring of the weight of the plasma components collected after centrifugation by the centrifuge device;

[0041] The control module is electrically connected to the calculation module, the centrifugal device, the blood pump, and the plasma weight monitor respectively, and is used to receive the data...

Embodiment 2

[0043] This example discloses a method of the present invention that can reduce the amount of white blood cells mixed in the collected plasma, and its flow chart is shown in the attached figure 1 Shown: first obtain the donor's hematocrit HCT value and calculate the donor's optimal plasma collection volume Ps per cycle according to the HCT value, then introduce the above-mentioned donor's whole blood into the centrifuge device to separate the plasma, During the process, the plasma volume P collected in the plasma collection bag is monitored in real time. When P is 0.8Ps, increase the speed of the centrifugal device and reduce the speed of whole blood introduction until P=P S Plasma collection was completed.

[0044] The method for calculating the optimal plasma collection volume Ps per cycle is:

[0045] Q×HCT D =V×HCT B (1);

[0046] Q+K=V+P J (2);

[0047] K / Q=α (3);

[0048] From formula (1) and substitution (3) into formula (2), we can get:

[0049]

[0050] I...

Embodiment 3

[0061] This example discloses a method of the present invention that can reduce the amount of white blood cells mixed in the collected plasma. Compared with Example 2, only the operating parameters are different, and the rest of the conditions are the same. In this embodiment, when P is 0.7Ps, increase the rotational speed of the centrifugal device and reduce the blood introduction speed of whole blood until P=P S Plasma collection was completed.

[0062] In this example, the HCT value of the donor is 47%, the anticoagulation ratio is 1:16, the dynamic volume of the centrifuge cup is V=275mL, and the hematocrit in the cup is HCT B = 0.77.

[0063] Calculate according to the above formula:

[0064]

[0065] It is calculated that if the target collection amount calculated in each cycle is P J =212mLs = 212 mL.

[0066] When the donor's whole blood is introduced into the centrifuge, the initial rotation speed of the centrifuge is 7300RPM; the introduction speed of the whol...

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Abstract

The invention discloses a method and plasma collection system capable of reducing the mixing amount of leukocytes in collected plasma. The problem of excessive mixing of leukocytes in the plasma in the prior art is solved. The method includes the steps that first a hematocrit HCT value of a donor is obtained and an optimal plasma collection volume per cycle Ps of the donor is calculated accordingto the HCT value, then the whole blood of the donor is introduced into a centrifugal device for separation to obtain plasma, a plasma volume P collected in a plasma collection bag is monitored in realtime during the process, when the P is 0.7-0.9 Ps, the rotation speed of the centrifugal device is increased and the blood introduction speed of the whole blood is reduced until the plasma collectionis completed when P=PS. The method and plasma collection system are scientific in design, simple in method and simple to operation, the mixing amount of leukocytes in plasma can be effectively reduced, and the requirements of clinical plasma are met.

Description

technical field [0001] The invention belongs to the technical field of blood products, and in particular relates to a method and a plasma collection system capable of reducing the mixed amount of white blood cells in collected plasma. Background technique [0002] Plasma is the raw material for producing blood products, and its only source is healthy human body, so raw plasma is a precious and rare resource. At present, the collection of raw plasma is mainly obtained through centrifugation; plasma collection usually uses a disposable sterile pipeline to introduce the collected whole blood into a centrifugal plasma separation cup, and the centrifugal cup rotates at a high speed under the drive of the motor. Depending on the density of blood components, the blood is generally separated into a plasma layer, a buffy coat layer (platelets and white blood cells, etc.) and a red blood cell layer, and the plasma is collected into a plasma collection bag for making blood products or ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/38A61M1/36B04B15/00G06F17/11
CPCA61M1/38A61M1/382A61M1/3693B04B15/00G06F17/11
Inventor 王鹏李川
Owner 四川天府亨特生命科技有限公司
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