Vaccine compositions
A composition and vaccine technology, applied in the field of vaccine compositions, can solve problems such as damage to the immune site of vaccines
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0169] Example 1 - Tissue reactivity of vaccines containing different adjuvants
[0170] method
[0171] animal
[0172] Ninety Merino wethers aged 24-36 months were sourced from a flock in an area (Armidale, NewSouth Wales) with no previous history of JD. Absence of JD was confirmed by repeated whole-flock stool testing and antibody enzyme-linked immunosorbent assay (ELISA) (Begg et al. 2010). The animals were transferred to a JD-free farm at the University of Sydney Camden and maintained under conventional Australian sheep farming conditions by grazing in open pasture.
[0173] ethics
[0174] All animal experiments were performed under the approval of the University of Sydney Animal Ethics Committee.
[0175] treatment group
[0176] Sheep were recruited and systematically randomized into 18 groups of 5 sheep in each group. A single dose of the new vaccine, including one unadjuvanted vaccine, was assigned to the first eight groups of animals (Table 1). The next e...
Embodiment 2
[0206] Example 2 - Efficacy of vaccine formulations
[0207] method
[0208] Thirty calves originating from a herd in NSW, Australia, were proved free of Johne's disease by on-farm monitoring of the infection status of their dams using antibody ELISA, faecal culture, and IS900 PCR of the entire herd. Prior to this study, all calves had been shown to be free of detectable Mptb infection by fecal culture, antibody and whole blood IFN-γ ELISA. The animals were managed by pasture grazing in open paddocks under conventional Australian farming conditions.
[0209] Calves aged 1.5 months were divided into two groups of 15 for vaccination. One group was tagged and a second group was tagged and vaccinated with a single dose of bovine vaccine (CV) 1 (Table 4).
[0210] One month later, animals from each treatment group were divided into 2 groups, 5 unexposed controls (n=5) and Mptb-vaccinated calves (n=10) (Table 4). Control animals were housed separately from inoculated animals...
PUM
| Property | Measurement | Unit |
|---|---|---|
| refractive index | aaaaa | aaaaa |
| refractive index | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More