Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Belladonna extract and belladonna extract compound recipe preparation

A technology of belladonna extract and compound preparation, applied in the field of medicine, can solve the problems of high chlorophyll content, incomplete removal of impurities, and low purity of belladonna extract, and achieve the effects of less loss, high extraction efficiency, and simple process

Active Publication Date: 2020-08-28
HONGMEI PHARMA CHINA
View PDF4 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But above-mentioned method gained belladonna extract chlorophyll content is more, and purity is lower, impurity removal is not thorough

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Belladonna extract and belladonna extract compound recipe preparation
  • Belladonna extract and belladonna extract compound recipe preparation
  • Belladonna extract and belladonna extract compound recipe preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Embodiment 1 belladonna extract

[0069] The present embodiment provides a kind of belladonna extract, the extraction method of described belladonna extract is as follows:

[0070] (1) 1000g belladonna is roughly crushed into coarse powder (particle size is about 2.0mm), and the coarse powder is added to the ethanol solution containing 0.1% sulfuric acid (percolation extraction solvent, about 3000ml, the same below), at 600W Ultrasonic mixing for 4h;

[0071] (2) The belladonna coarse powder after the ultrasonic treatment is percolated (with the ethanol solution containing 0.1% sulfuric acid in step 1 as the percolation extraction solvent, and the insufficient part is filled), the flow rate of the percolation is 3ml / min , collect 6000ml of percolation liquid; carry out decompression concentration (control temperature below 60 ℃, specific gravity 1.03) of described percolation liquid, obtain the first concentrated liquid;

[0072] (3) Use filter paper to suction filter...

Embodiment 2

[0078] Embodiment 2 belladonna extract

[0079] The present embodiment provides a kind of belladonna extract, the extraction method of described belladonna extract is as follows:

[0080] (1) Coarsely crush 1000 g of belladonna into a coarse powder (particle size is about 2.0 mm), add the coarse powder to an ethanol solution containing 0.1% hydrochloric acid (percolation extraction solvent), and ultrasonically mix at 600W for 4 hours;

[0081] (2) The belladonna coarse powder after ultrasonic treatment is percolated (with the ethanol solution containing 0.1% hydrochloric acid in step 1 as the percolation extraction solvent, the insufficient part is filled), the flow rate of the percolation is 3ml / min , collect 6000ml of percolation liquid; carry out decompression concentration (control temperature below 60 ℃, specific gravity 1.03) of described percolation liquid, obtain the first concentrated liquid;

[0082] (3) Use filter paper to suction filter the first concentrated solu...

Embodiment 3

[0088] Embodiment 3 belladonna extract

[0089] The present embodiment provides a kind of belladonna extract, the extraction method of described belladonna extract is as follows:

[0090] (1) Coarsely crush 1000 g of belladonna into a coarse powder (with a particle size of about 2.0 mm), add the coarse powder to an ethanol solution containing 0.3% hydrochloric acid (percolation extraction solvent), and ultrasonically mix at 600 W for 4 hours;

[0091] (2) The belladonna coarse powder after the ultrasonic treatment is carried out percolation (with the ethanol solution containing 0.3% hydrochloric acid in step 1 as the percolation extraction solvent, the insufficient part is made up), the flow rate of the percolation is 3ml / min , collect 6000ml of percolation liquid; carry out decompression concentration (control temperature below 60 ℃, specific gravity 1.03) of described percolation liquid, obtain the first concentrated liquid;

[0092] (3) Use filter paper to suction filter t...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to the technical field of medicines, in particular to a belladonna extract and a belladonna extract compound recipe preparation. An extraction method of the belladonna extract comprises the steps of performing diacolation extraction on belladonna herb coarse powder with an ethanol containing solvent; and concentrating the obtained diacolation extract, performing washing withethanol, and performing centrifugal separation to obtain supernatant, wherein the solvent contains 0.1-0.3% of acid. The method further comprises the steps of adjusting the pH value of supernatant to3-4, performing purifying with macroporous resins (such as NKA-II type), and performing gradient elution with 80-95% of an ethanol solution and 65-75% of the ethanol solution. The extraction method can effectively reduce the content of chlorophyll and impurities in the belladonna extract, and can improve the quality of the belladonna extract. Besides, the invention provides the belladonna extractcompound recipe preparation containing the belladonna extract, and components in the preparation and a preparation technology are optimized, so that the stability of the preparation can be effectivelyimproved.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a compound preparation of belladonna extract and belladonna capsules. Background technique [0002] The main source of belladonna extract is the extract made from processed belladonna herb. It is mainly used for gastric and duodenal ulcers, chronic gastritis, etc. [0003] According to "Chinese Pharmacopoeia" (page 397 of the 2010 edition), the preparation method of belladonna extract is: take 1000 grams of belladonna coarse powder, use 85% ethanol as a solvent, and soak it for 48 hours at a rate of 1 to 3 ml per minute. Slowly percolate, collect about 3000ml of the initial decant liquid, store it in another device, continue percolation, and when the alkaloids are completely decanted, the continuous percolation liquid is used as the solvent for the next percolation; the initial decant liquid is decompressed at 60°C to recover ethanol , let cool to room temperature, separate th...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61K9/48A61K47/36A61K47/04A61P1/04A61P1/00A61K33/00
CPCA61K36/81A61K33/00A61K9/4866A61P1/00A61P1/04A61K9/485A61K2236/333A61K2236/39A61K2236/53A61K2236/51A61K2236/55A61K2300/00
Inventor 李泽恩常永亮黄元进王超毕英南张慧慧
Owner HONGMEI PHARMA CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com