Application of spermidine in preparation of preparation for improving bacterial abundance of lachnospiraceae

A technology of Lachnospira and spermidine, which is applied in the application field of spermidine in the preparation of preparations for increasing the abundance of Lachnospira bacteria, to achieve the effects of increasing bacterial abundance and improving intestinal barrier function damage

Inactive Publication Date: 2020-09-04
ZHEJIANG UNIV OF TECH
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Problems solved by technology

Although the current implementation of FMT still lacks clear clinical trial effects, the exploration of ef

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  • Application of spermidine in preparation of preparation for improving bacterial abundance of lachnospiraceae
  • Application of spermidine in preparation of preparation for improving bacterial abundance of lachnospiraceae
  • Application of spermidine in preparation of preparation for improving bacterial abundance of lachnospiraceae

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Embodiment 1

[0022] 1. Animal handling

[0023] 7-week-old male C57BL / 6 mice were reared under standard experimental conditions: 25±2°C, 50±5% humidity, 12h / 12h light / dark cycle. 40 mice were equally divided into 5 groups (control group, high-fat diet group, low-dose spermidine group, middle-dose spermidine group and high-dose spermidine group). Calculate the concentration of spermidine aqueous solution according to the weight of the mouse, for example, for a mouse with a body weight of 25g, dissolve 0.125mg of spermidine powder in 5ml sterile water to obtain a 25mg / L aqueous solution of spermidine, configure each mouse according to the weight of the mouse The mice ingested 5mg / kg of spermidine aqueous solution every day. The control group was given normal drinking water and common standard feed (energy is 3.52kcal / g), and the other groups were given high-fat feed (energy was 5.24kcal / g). The middle-dose amine group and the high-dose spermidine group also ingested 5 mg / kg, 10 mg / kg and 2...

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Abstract

The invention discloses an application of spermidine in preparation of a preparation for improving the bacterial abundance of lachnospiraceae. The bacterial abundance of the lachnospiraceae NK4A136 group in the intestinal tract of an obese mouse can be remarkably improved by taking in exogenous spermidine, and the intestinal tract barrier function damage induced by metabolism related diseases suchas obesity is improved.

Description

[0001] (1) Technical field [0002] The invention relates to the application of spermidine, a polyamine substance, mainly the application of spermidine in the preparation and development of drugs related to Lachnospira and functional foods. [0003] (2) Background technology [0004] Gut microbes are an important part of the body's microecosystem, which can regulate the health of the human gut and maintain the body's immune and metabolic homeostasis. Through sequencing technology, it was found that the intestinal microbiota was mainly composed of bacteria, and the dominant species belonged to the bacteria of Firmicutes and Bacteroidetes. The coexistence of intestinal microorganisms and the body constitutes the intestinal microecological system. When the intestinal microecological system is out of balance, the intestinal microorganisms will undergo corresponding changes, such as the increase of pathogenic bacteria and the decrease of beneficial bacteria, which will damage the im...

Claims

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Application Information

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IPC IPC(8): A61K31/132A61P1/00A61P3/04A61P3/00A23L33/10
CPCA23V2002/00A61K31/132A23L33/10A61P1/00A61P3/00A61P3/04A23V2200/32
Inventor 倪银华马灵燕倪利阳傅正伟
Owner ZHEJIANG UNIV OF TECH
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