Precise sodium adjusting method for displacement liquid formula

A kind of replacement fluid and precise technology, applied in the field of clinical medicine, can solve the problem of not considering metabolic acid-base balance disorders, etc., and achieve the effect of preventing cerebral edema, solving the problem of anticoagulation, and slowly reducing sodium cerebral edema.

Pending Publication Date: 2020-10-27
NANHUA HOSPITAL AFFILIATED TO UNIV OF SOUTH CHINA
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Problems solved by technology

This formula is not for sodium citrate anticoagulant CRRT treatment, nor does it take into account the factors of metabolic acid-base balance imbalance, but simply considers the relationship between ...

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  • Precise sodium adjusting method for displacement liquid formula
  • Precise sodium adjusting method for displacement liquid formula
  • Precise sodium adjusting method for displacement liquid formula

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Embodiment 1

[0060] Embodiment of this example: continuous venous-venous hemofiltration (CVVH) mode, blood flow rate 150mL / h, replacement fluid velocity 3L / h, 4% sodium citrate consumption starting from 200mL / h (according to ionized calcium after the filter Concentration adjustment, maintaining the ionized calcium after the filter at 0.2-0.5mmol / L), the sodium concentration in the initial replacement fluid is 10-14mmol / L lower than the patient’s serum sodium, and the dosage of 5% sodium bicarbonate is adjusted according to the blood gas results of the patient. When the acid-base balance is out of balance, the dosage of 5% sodium bicarbonate is 88mL / h per 1L of replacement solution, and the potassium ion is adjusted according to the test results of the patient. The exact calculation formula for the initial sodium ion is as follows:

[0061] 1. For patients with metabolic acidosis or without acid-base balance disorder, the calculation method is as follows:

[0062] Step 1: Determine the hou...

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Abstract

The invention relates to the technical field of clinical medicine, in particular to a precise sodium adjusting method for a displacement liquid formula. For patients with metabolic acidosis or withoutacid-base balance disorders, the amount I1 of 10% sodium chloride solution added to an initial displacement liquid can be obtained by a formula 1 and a formula 2, and for patients with metabolic alkalosis, the amount I6 of 10% sodium chloride solution added to the initial displacement liquid can be obtained by a formula 7 and a formula 8. The simple and easy-to-master formulas are adopted, the sodium ion concentration of the displacement liquid is precisely adjusted to achieve a controlled sodium reduction effect, the sodium reduction effect is accurate, the sodium reduction is balanced and stable every hour, and the sodium is adjusted individually according to different patients, the anti-coagulation problem in CRRT treatment for severe hypernatronemia accompanied by active bleeding patients is solved, meanwhile, the occurrence of complications during the anticoagulation process is prevented, balanced and stable sodium reduction is realized, and the occurrence of cerebral edema is reduced.

Description

technical field [0001] The invention relates to the technical field of clinical medicine, in particular to a precise sodium adjustment method for a replacement fluid formula. Background technique [0002] Hypernatremia is a serious clinical complication that is common and easily overlooked. Studies have shown that the incidence of hypernatremia in critically ill patients is 4% to 26%, and the incidence of severe hypernatremia (serum sodium ≥ 160mmol / L) is only 0.6% to 1.0%. The short-term fatality rate is 58% to 87%. Hypernatremia can cause dysfunction of multiple systems, including nerves, immunity, endocrine, and circulation. Smooth sodium reduction is crucial to maintaining a stable internal environment and reducing the occurrence of cerebral edema. Traditional treatment is mainly to restrict sodium intake and supplement non-salt fluid according to the degree of dehydration and continuous dehydration. Acute severe hypernatremia requires rapid supplementation of 5% gluc...

Claims

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Application Information

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IPC IPC(8): A61M1/16A61K33/14A61P3/12A61P7/08A61P7/04A61K31/7004A61K33/06A61K31/194
CPCA61K31/194A61K31/7004A61K33/06A61K33/14A61M1/1654A61M1/1656A61M2202/0413A61P3/12A61P7/04A61P7/08A61M2202/0021A61K2300/00
Inventor 邓凤英罗湘俊杨雪艳刘斌玉欧玲刘洋
Owner NANHUA HOSPITAL AFFILIATED TO UNIV OF SOUTH CHINA
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