Quinoline derivative or pharmaceutically acceptable salt thereof for combined treatment of interstitial lung disease

An interstitial, therapeutic drug technology, applied in the field of medicine, can solve problems such as affecting the prognosis of patients

Inactive Publication Date: 2020-11-20
CHIA TAI TIANQING PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, while seeing hope, the side effects caused by radiotherapy, chemotherapy and targeted therapy, especially the occurrence of interstitial lung disease seriously affect the prognosis of patients, and become a problem that cannot be ignored in the future treatment process

Method used

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  • Quinoline derivative or pharmaceutically acceptable salt thereof for combined treatment of interstitial lung disease
  • Quinoline derivative or pharmaceutically acceptable salt thereof for combined treatment of interstitial lung disease

Examples

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Embodiment Construction

[0055] The present application will be further described below in conjunction with specific examples, however, these examples in the present application are only used to illustrate and not limit the scope of the present application. Likewise, the application is not limited to any particular preferred embodiments described herein. Those skilled in the art should understand that equivalent replacements or corresponding improvements to the technical features of the present application still fall within the protection scope of the present application. Unless otherwise specified, the reagents used in the following examples are all commercially available products, and the preparation of the solution can adopt conventional techniques in the art.

[0056] According to the content disclosed in the application, although the composition and method of the application have been described according to the preferred embodiment, but for those skilled in the art, without departing from the con...

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Abstract

The invention discloses a quinoline derivative or a pharmaceutically acceptable salt thereof for combined treatment of interstitial lung diseases. The invention provides application of combination ofa therapeutically effective amount of quinoline compound I or the pharmaceutically acceptable salt thereof and a therapeutically effective amount of second therapeutic drug in preparation of drugs fortreating interstitial lung diseases. The chemical name of the quinoline compound I is 1-[[[4-(4-fluoro-2-methyl-1H-indol-5-yl)oxy-6-methoxyquinoline-7-yl]oxy]methyl]cyclopropylamine.

Description

technical field [0001] The application belongs to the technical field of medicine, and relates to the use of quinoline derivatives or pharmaceutically acceptable salts thereof for combined treatment of interstitial lung diseases. Background technique [0002] Lung cancer is currently one of the most common malignant tumors in the world. The treatment methods for lung cancer mainly include surgery, chemotherapy, radiotherapy and targeted therapy. However, various related side effects will inevitably occur during treatment. Interstitial lung disease (ILD) is one of the main side effects of radiotherapy, chemotherapy and targeted therapy. ILD is characterized by diffuse pulmonary parenchyma, alveolitis, and interstitial fibrosis as the basic pathological changes, and is clinically manifested by active dyspnea, diffuse shadows on chest X-ray, restrictive ventilatory disturbance, decreased diffusion function, and hypoxemia An umbrella term for the clinicopathological entities th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/475A61K45/06A61P11/00
CPCA61K31/475A61K45/06A61P11/00
Inventor 徐萍王诚倩
Owner CHIA TAI TIANQING PHARMA GRP CO LTD
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