A kind of long-acting liquid gel containing rose essential oil and its preparation method and application

A technology of rose essential oil and gel, applied in the field of medicine, can solve the problems of no inflammatory injury such as ulcers, no wound healing of rose essential oil, etc., to achieve the effects of promoting wound healing, relieving wound pain, and maintaining natural elasticity

Active Publication Date: 2022-08-09
SHAOXING UNIVERSITY +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing cosmetics with rose essential oil as the main active ingredient in the market are lotions, creams, perfumes, etc., which are mainly used to enhance the smell of the product, moisturize skin care and improve the mood of the user, but so far, no rose essential oil can promote According to research reports on wound healing, there is no long-acting in-situ slow-controlled release rose essential oil gel product that can treat ulcers and other inflammatory injuries.

Method used

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  • A kind of long-acting liquid gel containing rose essential oil and its preparation method and application
  • A kind of long-acting liquid gel containing rose essential oil and its preparation method and application
  • A kind of long-acting liquid gel containing rose essential oil and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 Liquid gel preparation process

[0033] According to the formulation of the liquid gel preparation of the present invention, polyglycerol fatty acid ester (PG) / soybean lecithin (PC) / rose essential oil (REO) / ethanol (EtOH)=48 / 32 / 10 / 10 (mass ratio). First, precisely weighed PC, PG and medicinal ethanol (EtOH) of 25% of the final liquid gel volume of the recipe were placed in a round-bottomed flask, sealed, and incubated on a constant temperature water bath magnetic stirrer at a speed of 100 rpm and 40 °C. , until PC and PG are completely dissolved to prepare a homogeneous and clear solution A of PC / PG / EtOH, the concentration of (PC+PG) in A can be adjusted to 200-1000 mg·mL as required -1 , preferably 500 to 1000 mg·mL -1 , more preferably 750 to 950 mg·mL -1 Next, remove all or almost all EtOH from solution A with a rotary evaporator (vacuum, 40° C., 1 h) to obtain a liquid mixture B, the residual amount of EtOH in the B should not be greater than 0.1%, ot...

Embodiment 2

[0034] Example 2 Investigation of the influence of PC / PG ratio on the formation of liquid gel

[0035] Various liquid crystal phases (L 2 , I 2 , H II , L ɑ ), prepare the liquid gel preparation containing different proportions of phosphatidylcholine (PC) and polyglycerol fatty acid ester (PG) and use EtOH as the organic solvent according to the method of Example 1, after balancing with excess water, different liquid crystal phase.

[0036] Table 1 Investigation of the effect of PC / PG ratio on the formation of liquid gel

[0037]

[0038] a.q. = solution state

[0039] L 2 = reverse cubic phase

[0040] I 2 = Inverse cubic liquid crystal phase

[0041] H II = Inverse hexagonal liquid crystal phase

[0042] L ɑ = layered crystal phase

Embodiment 3

[0043] Example 3 Investigation of the influence of different PC species on the formation of liquid gel

[0044] According to the method described in Example 1, liquid gel formulations with different kinds of PC were prepared, and the final liquid gel formulation contained 32.7% PC, 55.5% PG, 10% EtOH and 1.8% REO in mass ratio, balanced with excess water After that, different liquid crystal phases can be obtained, but all contain I 2 Mutually.

[0045] Table 2 Investigation of the effect of different PC species on the formation of liquid gels

[0046]

[0047]

[0048] Remark:

[0049] 1. Soybean lecithin: German Lipoid Company, S100 series, of which the PC content is greater than 94%;

[0050] 2. Egg yolk phospholipid: German Lipoid Company, EPCS series, of which the PC content is greater than 96%;

[0051] 3. Other phospholipids such as di-transoleoylphosphatidylcholine, dioleoylphosphatidylethanolamine, dioleoylphosphatidylglycerol, dioleoylphosphatidylserine, and d...

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Abstract

The invention provides a long-acting liquid gel containing rose essential oil, a preparation method and application thereof, wherein the liquid gel contains phospholipid (PC), polyglycerol fatty acid ester (PG), rose essential oil (REO) and an organic solvent. The advantages of the long-acting liquid gel for treating oral wounds (especially oral ulcers) provided by the present invention are: first, the liquid gel of the present invention is a low-viscosity flowing liquid before use, and when it encounters an aqueous solution after use, it is A high-viscosity gel is formed, which is convenient for filling and using local cavities of the body, and has a long duration of action; secondly, the liquid gel of the present invention is rich in natural rose essential oil, fused with a variety of polyglycerol derivatives as raw materials, and has no immunogenicity. Good biodegradability, can promote wound healing, relieve wound pain, and can further restore and maintain the natural elasticity of the skin; third, the liquid gel of the present invention does not contain any preservatives, but the validity period is greater than 3 years, and within 5 years Product performance has not changed.

Description

technical field [0001] The invention belongs to the technical field of medicine, and particularly relates to a long-acting liquid gel containing rose essential oil and a preparation method and application thereof. Background technique [0002] For conventional drug delivery systems, multiple doses can be administered to maintain high blood drug concentrations for a long time. However, for parts such as tissue space, organ surface, joint cavity, oral cavity, etc., which are hidden and filled with body fluids, it is almost impossible to continuously administer multiple doses, and it is difficult to maintain the blood drug concentration; and for local lesions, it is not medically recommended for the whole body. Drugs for treatment can easily lead to adverse reactions. Therefore, there is an urgent need for a long-acting in situ sustained and controlled release pharmaceutical preparation that can be easily operated. [0003] At present, the gel products on the market are gener...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/92A61K8/04A61K8/37A61K8/49A61K8/55A61K8/86A61K36/738A61K9/06A61K47/24A61K47/14A61P1/02A61P17/02A61Q17/04A61Q19/00A61Q19/02
CPCA61K8/922A61K8/553A61K8/375A61K8/4993A61K8/86A61K8/042A61Q17/04A61Q19/02A61Q19/00A61K36/738A61K9/06A61K47/24A61K47/14A61P1/02A61P17/02Y02A50/30
Inventor 骆翔陈徐盈高超伟顾华芳徐歌杨继永吕东辉朱柯武沈润溥
Owner SHAOXING UNIVERSITY
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