Micro-droplet chip channel positioning device and method

A positioning method and positioning device technology, applied in chemical instruments and methods, laboratory utensils, laboratory containers, etc., can solve problems such as narrow channels and difficult channel positioning, and achieve good repeatability

Active Publication Date: 2022-01-18
TARGETINGONE TECH (BEIJING) CORP
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The characteristics of the injection molding material of the micro-droplet chip, coupled with the very narrow channel, make channel positioning difficult

Method used

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  • Micro-droplet chip channel positioning device and method
  • Micro-droplet chip channel positioning device and method
  • Micro-droplet chip channel positioning device and method

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Embodiment Construction

[0036] see in conjunction Figure 1 to Figure 7 As shown, according to an embodiment of the present invention, a micro-droplet chip channel positioning device is provided, including: a chip loading unit for installing a micro-droplet chip 10, and a channel 11 is configured on the micro-droplet chip 10 (can include a detection channel), its horizontal position is adjusted by a horizontal drive motor 12; the optical unit is used to overlap the laser light path with the visible light imaging light path on the same axis, and it includes an objective lens 20, which is connected with a charge-coupled device 21 (CCD , Charge CoupledDevice), the vertical position of the objective lens 20 is adjusted by the vertical drive motor 22, and the charge-coupled device 21 is used for imaging the micro-droplet chip 10; the laser emission source 30 emits the laser light through the objective lens 20 A laser light path is formed on the micro-droplet chip 10, which is used for fluorescently exciti...

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Abstract

The invention provides a channel positioning device and method for a micro-droplet chip, wherein the channel positioning device for a micro-droplet chip includes: a chip loading unit for installing a micro-droplet chip, and a channel is configured on the micro-droplet chip , its horizontal position is adjusted by a horizontal drive motor; the optical unit is used to coincide the laser optical path with the visible light imaging optical path on the same axis, including the objective lens, which is connected with a charge-coupled device, and the vertical position of the objective lens is adjusted by a vertical drive motor; the laser emission source , forming a laser light path; a white light source, forming a visible light imaging light path; a control unit, communicating with a charge-coupled device, to calculate and analyze the image obtained by the charge-coupled device to obtain an adjustment value, and control the horizontal drive motor and / or the vertical drive according to the adjustment value The drive motor runs. The digital image acquisition of the micro-droplet is simple and convenient, the digital image is more intuitive, the channel positioning accuracy is high, and the repeatability is good.

Description

technical field [0001] The invention belongs to the technical field of micro-droplet detection, and in particular relates to a micro-droplet chip channel positioning device and method. Background technique [0002] Micro-droplet microfluidics (droplet-based microfluidics) is a technology platform developed on microfluidic chips in recent years to manipulate small-volume liquids. Its principle is: two immiscible liquids, for example, One of them is the oil phase, and the other is the water phase. After the oil phase and the water phase enter the microchannel at the same time, under the action of the microchannel, the water phase is formed in a small volume (10 -15 ~10 -9 The form of L) unit is distributed in the oil phase, forming a series of discrete micro-droplets. Each droplet acts as a microreactor to complete a set of chemical or biological reactions. [0003] The micro-droplets flow through the detection area in a line-by-line manner, and the laser is shot vertically...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
CPCB01L3/502707B01L2300/0654
Inventor 白宇樊东东夏雷刘晓彬杨文军
Owner TARGETINGONE TECH (BEIJING) CORP
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