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A Clean Isophase Layer-Selected Homonucleus Selective Coherence Spectroscopy Method

A nuclear-selective and selective technology, applied in the nuclear magnetic resonance field of layer-selective nuclear selective coherence spectroscopy, can solve the problems of difficulty in spectral analysis and consumption of experimental time, and achieve the effect of reducing experimental time and avoiding signal self-cancellation.

Active Publication Date: 2022-04-05
XIAMEN UNIV +1
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Problems solved by technology

However, since the final signal is composed of the in-phase component and the anti-phase component, when the positive and negative signals are close to each other, the resulting self-cancellation makes spectrogram analysis difficult
In addition, the "soft" COZY experiment with non-parallel sampling can only measure the coupling relationship between one excited nucleus and one observed nucleus at a time, which will consume double the experimental time when measuring all the coupling situations of a given proton in the sample

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  • A Clean Isophase Layer-Selected Homonucleus Selective Coherence Spectroscopy Method
  • A Clean Isophase Layer-Selected Homonucleus Selective Coherence Spectroscopy Method
  • A Clean Isophase Layer-Selected Homonucleus Selective Coherence Spectroscopy Method

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Embodiment Construction

[0022] Below in conjunction with accompanying drawing and embodiment, the present invention will be further described:

[0023] The invention provides a clean and homogeneous layer-selected homonuclear selective coherence spectrum method, which is characterized in that it comprises the following steps:

[0024] 1) collecting the NMR one-dimensional spectrum of the sample;

[0025] 2) Measure the pulse width of the 180-degree hard pulse of the sample;

[0026] 3) Measure the pulse width and time of the sample's excitation nuclear 90-degree selective pulse, observation nuclear 90-degree selective pulse, and inversion 90-degree selective pulse;

[0027] 4) Set dephasing gradient G 1 , G 2 and G 3 the intensity and duration of

[0028] 5) Set the central position of the excited hydrogen nucleus to be studied as the center frequency of the selective 90-degree selective pulse of the excited nucleus, and set the central position of the observed hydrogen nucleus to be studied as ...

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Abstract

The invention provides a clean and homogeneous layer-selective homonuclear selective coherence spectrum method. The modified perfect echo module is used to realize the coherent transfer between the same phases and combined with selective pulse and dephasing gradient to remove unwanted signals, and finally only the excitation nucleus and the observation nucleus are modulated by the cosine function t 1 , t 2 The temporal J-coupling modulates the signal, and the signal strength is affected by the Δ value. The two-dimensional J-coupling modulation of the excited nucleus and the observed nucleus will present an in-phase square in the spectrum, the coupling information of the observed nucleus and other nuclei is reflected in the lateral offset of the square, and the coupling information of the excited nucleus and other nuclei is reflected in the The vertical offset of the square is on, and since the modulation that causes the horizontal and vertical offset is also a cosine modulation, it will not affect the property that the spectral peaks are in-phase.

Description

technical field [0001] The invention relates to a nuclear magnetic resonance method, in particular to a nuclear magnetic resonance method with clean and homogeneous layer-selective homonuclear selective coherence spectrum. Background technique [0002] NMR spectroscopy is a powerful analytical tool with a wide range of applications. J-coupling is an important parameter in NMR spectroscopy, which can provide valuable information about molecular structure and conformation. Among them, two-dimensional correlation spectroscopy (“COSY”) experiments that provide molecular J-coupling relationships play an indispensable role in molecular resolution, but their numerical resolution has been low due to the limited number of sampling points in the indirect dimension. Numerical resolution can be improved by a selective ("soft") COZY method, which facilitates the analysis of the coupling constant between a given proton and its coupled pair. However, since the final signal is composed of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N24/08
CPCG01N24/08
Inventor 林雁勤董曦曾庆
Owner XIAMEN UNIV
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