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Use of the alcoholic extract of Zhuang medicine five leaves as the preparation of anti-gouty arthritis medicine

A technology of gouty arthritis and Wuyepao, which is applied in the field of medicine to achieve the effect of reducing joint damage, alleviating related symptoms, and inhibiting the release of inflammatory factors

Active Publication Date: 2022-07-05
GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There is no report about the application of Wuyepao extract in gouty arthritis

Method used

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  • Use of the alcoholic extract of Zhuang medicine five leaves as the preparation of anti-gouty arthritis medicine
  • Use of the alcoholic extract of Zhuang medicine five leaves as the preparation of anti-gouty arthritis medicine
  • Use of the alcoholic extract of Zhuang medicine five leaves as the preparation of anti-gouty arthritis medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The method for extracting the alcohol extract of C. quinquefolium: extracting the C. quinquefasciatus with 8 times the amount of ethanol for 4 times, each time for 2 hours, the extracts are combined, filtered and concentrated to obtain the alcoholic extract paste of C. quinquefasciatus.

Embodiment 2

[0028] The extraction method of the alcohol extract of the five-leaf tea: take the five-leaf tea and add 9 times the amount of ethanol to extract three times, each time for 3 hours, the extracts are combined, filtered and concentrated to obtain the five-leaf tea alcohol extract paste.

Embodiment 3

[0030] Method for extracting alcohol extract of Phytophthora quinquefolia: extract Fructus Fructus Fructus with 10 times the amount of ethanol for 3 times, each time for 2.5 hours, the extracts are combined, filtered and concentrated to obtain Phytophthora quinquefolium alcohol extract paste.

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Abstract

The invention discloses the use of the alcohol extract of Radix Rhizoma Radix as an anti-gouty arthritis drug. The extraction method of the ethanol extract from Radix Radix Rhizoma Radix is: taking Fructus Radix Rhizoma Radix with 7-10 times the amount of ethanol to extract 3 ~4 times, 2~3 hours each time, the extracts were combined, filtered and concentrated to obtain the alcohol extract paste of P. Pills, ointments and other traditional Chinese medicine forms. The present invention has been verified to show that the alcohol extract of five leaves can reduce the serum uric acid level in mice with hypoxanthine-induced hyperuricemia, has a good uric acid-lowering effect, and can relieve symptoms related to acute gouty arthritis and reduce joint pain. Injuries, inhibits the release of inflammatory factors, has the potential to prepare pharmaceutical preparations for the prevention and treatment of gouty arthritis, provides a new material basis for the development of anti-gouty arthritis drugs, and has potential and huge social and economic benefits.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the use of an alcoholic extract of Radix Polygoni Radix as an anti-gouty arthritis medicament. Background technique [0002] Gouty arthritis is caused by the deposition of urate in joint capsules, bursae, cartilage, bone and other tissues causing lesions and an inflammatory response. It usually occurs at night, and the affected joints are painful. The first joint often involves the first metatarsophalangeal joint, followed by the ankle and knee. Joint redness, swelling, heat and tenderness, general weakness, fever, headache, etc. Gout is a metabolic disease caused by abnormal purine metabolism resulting in increased uric acid synthesis. Plasma saturation of uric acid results in the deposition of monosodium urate crystals in relatively vascularized tissues around distal joints. The appearance of such crystals can lead to acute inflammatory synovitis in single or multiple joints...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/73A61P19/06A61P19/02A61P9/10A61P9/12A61P13/12A61K125/00
CPCA61K36/73A61P19/06A61P19/02A61P9/10A61P9/12A61P13/12A61K2236/333A61K2236/53A61K2236/39Y02A50/30
Inventor 吕纪华王丽邓聿胤刘瑛饶伟源
Owner GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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