A cell membrane-coated au-fe 3 o 4 Targeted nanomaterials and their preparation methods and applications

An au-fe3o4 and nanomaterial technology, which is applied in the field of targeted nanomaterials coated with Au-Fe3O4 on cell membranes and their preparation, can solve problems such as the influence of normal cells, hindering the curative effect of CDT therapy, and harming the normal functions of the human body.
CN112791062BActive Publication Date: 2022-03-08山东济清科技服务有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
山东济清科技服务有限公司
Publication Date
2022-03-08

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Abstract

The invention provides a cell membrane coated Au-Fe 3 o 4 The targeted nanomaterial and its preparation method and application belong to the technical field of targeted nanomaterials. Targeted nanomaterial cancer cell membrane provided by the present invention and Au-Fe wrapped in the cancer cell membrane 3 o 4 Nanoparticles, tannic acid and phorbol 12‑myristate 13‑acetate. PMA can effectively stimulate cells to produce H 2 o 2 and reactive oxygen species 2 ‑ , can suppress the insufficient H in cancer cells 2 o 2 Supplement to supplement raw materials for Fenton reaction; Fe 3 o 4 Can be partially decomposed in the presence of tannic acid to form Fe 2+ and Fe 3+ , Fe 2+ Can catalyze H in cancer cells 2 o 2 Decomposed into hydroxyl radicals, TA can promote Fe 3 o 4 Produced Fe 3+ to Fe 2+ Rapid transformation; at the same time, Au and Fe 3 o 4 It has good photothermal conversion efficiency and can give full play to the therapeutic effect of PTT.
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Description

technical field

[0001] The invention relates to the technical field of targeted nanomaterials, in particular to a cell membrane-coated Au-Fe 3 o 4 Targeted nanomaterials and their preparation methods and applications. Background technique

[0002] For centuries, cancer has been one of the focal issues threatening human health, and many scientific researchers have worked hard to overcome this problem. So far, various treatment methods have been researched and developed, such as chemodynamic therapy (CDT therapy), photodynamic therapy (PDT therapy), photothermal therapy (PTT therapy), etc., among which, the combination of CDT therapy and PTT therapy has produced Good therapeutic effect. CDT treatment mainly utilizes metal and H 2 o 2 The highly active hydroxyl radicals (·OH) produced by the Fenton reaction between them can kill tumor cells. Nano-catalyzed drugs currently available for CDT therapy mainly contain Fe 2+ 、Cu 2 + , Mn 2+ and Co 2+ and other metal ions. ...

Claims

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