Application of cubilose in preparation of medicine for treating ulcerative colitis

Abstract

The invention belongs to the technical field of pharmacology, and discloses application of cubilose in preparation of a medicine for treating ulcerative colitis. The medicine in the application can reduce MPO activity and IL-1beta and TNF-alpha contents in colon tissues of mice, enhance the resistance of organisms to external stimulating factors, alleviate weight loss of the mice due to DSS induction, improve colitis, reduce the level of proinflammatory factors, effectively relieve symptoms and inflammatory indexes of the ulcerative colitis, and provides a new thought for the development of medicines for treating the ulcerative colitis.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to the application of bird's nest in preparing medicine for treating ulcerative colitis. Background technique [0002] Ulcerative colitis (UC) is a chronic, idiopathic inflammatory disease that is always associated with mucosal inflammation, usually starting from the rectum and extending to the proximal colon, and lesions are more common in the colon. It mostly occurs in adults aged 30 to 40, and severe cases can cause disability. About 15% of UC patients need to undergo colectomy. According to relevant statistics, the annual direct or indirect treatment costs for UC in Europe and the United States are 1.25-2.91 billion euros and 810-14.9 billion U.S. dollars, respectively. [0003] However, the etiology and pathogenesis of ulcerative colitis are still not very clear. It is generally believed that the etiology of UC may be related to environmental factors, genetic fac...

AI Technical Summary

Problems solved by technology

However, there is a lack of relevant drug efficacy and mechanism of action analysis

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