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Prognostic risk assessment system for gastric cancer patients

A risk assessment system and gastric cancer technology, applied in the medical field, can solve the problems of many DNA methylation sites and high cost, and achieve the effects of good prognosis, survival, low cost, excellent sensitivity and specificity

Pending Publication Date: 2021-06-04
黑龙江省医院
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Problems solved by technology

However, there are many DNA methylation sites designed by this model, and the cost is high. It is necessary to find a more reasonable and representative DNA methylation site to build a model

Method used

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  • Prognostic risk assessment system for gastric cancer patients
  • Prognostic risk assessment system for gastric cancer patients
  • Prognostic risk assessment system for gastric cancer patients

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Embodiment Construction

[0048] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0049] The invention discloses a prognostic risk assessment system for patients with gastric cancer, which includes:

[0050] The gastric cancer methylation data acquisition module is used to obtain the TCGA gastric cancer methylation profile from the UCSC Xena database and the gastric cancer methylation profile dataset GSE30601 from the GEO database, wherein the TCGA gastric cancer methylation profile includes the first methyl The methylation data set and the...

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Abstract

A prognosis risk assessment system for gastric cancer patients is characterized by comprising a gastric cancer methylation data acquisition module, a differential methylation site acquisition module and a prognosis model construction module. The gastric cancer methylation data acquisition module is used for acquiring TCGA gastric cancer methylation spectrum and a gastric cancer methylation spectrum data set GSE30601, the differential methylation site acquisition module is used for obtaining a plurality of hyper-methylation sites and a plurality of hypo-methylation sites, and the prognosis model construction module is used for constructing a 11-DNA methylation site risk scoring formula of each patient.

Description

technical field [0001] The invention relates to the medical field, in particular to a prognostic risk assessment system for patients with gastric cancer. Background technique [0002] According to the latest global cancer statistics released by the World Health Organization in 2018, the incidence and mortality of gastric cancer rank fifth and third respectively. It is a characteristic cancer in East Asia, with an incidence rate of 32.1 per 100,000 people , the mortality rate is 13.2 / 100,000 people, among which, the morbidity and mortality rate of Japan, South Korea, and China are among the highest in the world [1]. Therefore, the prevention and treatment of gastric cancer should be highly valued. The diagnosis of gastric cancer is often late. Although the progress of surgery, radiotherapy, chemotherapy, molecular targeting and immunotherapy has improved its overall prognosis, it is still unsatisfactory[2-4]. Exploring effective biomarkers for gastric cancer patients Early d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16H50/30G16B20/00
CPCG16H50/30G16B20/00
Inventor 刘东辉王旭瑶孔鹏羽王超姜庆鑫刘威
Owner 黑龙江省医院
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