36results about How to "Excellent sensitivity" patented technology

The magnetic tape device includes a magnetic tape and a TMR head (servo head), in which the magnetic tape includes a non-magnetic support, and a magnetic layer including ferromagnetic powder and a binding agent on the non-magnetic support, the ferromagnetic powder is ferromagnetic hexagonal ferrite powder, an intensity ratio of a peak intensity Int(110) of a diffraction peak of a (110) plane with respect to a peak intensity Int(114) of a diffraction peak of a (114) plane of a hexagonal ferrite crystal structure obtained by an X-ray diffraction analysis of the magnetic layer by using an In-Plane method is 0.5 to 4.0, and a vertical direction squareness ratio of the magnetic tape is 0.65 to 1.00.

The invention discloses a preparation method of a high-sensitivity functionalized gold nanoparticle-doped phenprobamate MIECS (Molecular Imprinting Electrochemical Sensor). The preparation method is characterized by taking phenprobamate as a template molecule, aminotadalafil as a functional monomer, azodiisobutyronitrile as an initiator, dodecanethiol functionalized gold nanoparticles as a doping agent and hydrocortisone acetate as a coupling agent, thus preparing the high-sensitivity dodecanethiol functionalized gold nanoparticle-doped phenprobamate MIECS. An analysis method is simple and practical, and the disadvantages of complexity, expensive price of equipment and low sensitivity of a previous analysis method are overcome.

The invention discloses a peroxynitrite ion detection probe as well as a preparation method and application thereof. The peroxynitrite ion detection probe comprises a fluorescent nano material and an enzyme, wherein the enzyme is combined with the fluorescent nano material, has an oxidation-reduction property and can be selectively oxidized by peroxynitrite ions to form an oxidized enzyme; after the fluorescent nano material is radiated by excited light, electrons in an excited state can be transferred to the oxidized enzyme and cannot turn back to a base state, and then fluorescent light of the fluorescent nano material can be quenched. As an inorganic light-emitting material is adopted as fluorophore, the peroxynitrite ion detection probe disclosed by the invention is intense in light emission, good in stability and less prone to photo-bleach; the surface of the probe is modified with the enzyme with oxidation-reduction property, and the enzyme can be selectively oxidized by ONOO<->, so that the probe is not interfered by other active oxygen (ROS) or active nitrogen (RNS), and is excellent in specificity.

A method for test of human exhaled breath by using laser spectrums of optical frequency combs is characterized by: employing two groups of optical frequency combs with different pulse repetition frequencies to beat each other so that frequency spectrum signals are reduced to a microwave frequency range; employing a simple conventional microwave detection method to obtain frequency spectrum absorption and phase information of the exhaled breath in the entire optical frequencies, thereby to obtain gas components and traces; and determining a patient's possible condition by the analysis of components and corresponding absorption coefficients of each gas spectrum curve. The method for test of human exhaled breath by using laser spectrums of optical frequency combs of the invention can quickly measure the spectrum of human exhaled breath in a wide range once and for all, achieving a short measurement time and accurate measurement to real-time changing samples. The method has advantages of being non-invasive, quantitative, safe, simple, convenient, quick, repeatable, etc., with sensitivity and specificity better than conventional bronchoscopy.

The invention belongs to the field of chemical industry, and relates to a preparation method of graphene quantum dots for Hg<2+> detection and tumor diagnosis. The preparation method comprises: mixingan organic acid and a certain amount of azide-based functionalizing reagent, dissolving in water, stirring, and evaporating to obtain a mixture; carrying out a heating reaction on the prepared mixture at a certain temperature for a certain time to obtain functionalized graphene quantum dots; and dissolving the prepared functionalized graphene quantum dots in water, and carrying out tumor cell imaging or Hg<2+> concentration fluorescence determination. According to the present invention, the functionalized graphene quantum dots are prepared by using the organic acid as the carbon source and using the azide-based compound as the functionalizing reagent through the one-step reaction so as to achieve the specific recognition of tumor cells, and the specific bonding of the Hg<2+> and the functionalized graphene quantum dots can produce significant fluorescence quenching so as to achieve the highly-sensitive and highly-selective determination of the Hg<2+> concentration in the water sample.

The invention provides an alkali development-type photosensitive resin composition and a color alkali development-type photosensitive resin composition that are excellent in sensitivity, resolution, transparency, developability, adhesion, alkali resistance and the like and can form a fine pattern having a good shape with high accuracy. An alkali development-type photosensitive resin composition comprising a binder resin, a photopolymerization initiator, and a solvent, characterized in that the binder resin is a photopolymerizable unsaturated compound prepared by reacting an epoxy adduct with a specific proportion of a polybasic acid anhydride (D). The epoxy adduct has a structure prepared by adding, to a polyfunctional epoxy resin (A), an unsaturated monobasic acid (B), and a cyclic terpene structure skeleton-containing phenol compound (C-1), prepared by adding a specific proportion of phenol or an alkylphenol compound to a cyclic terpene compound, and/or an aliphatic alkylphenol compound (C-2).

The invention, which belongs to the field of sensors, in particular relates to an electronic skin and a preparation method thereof. The invention provides a piezoresistive electronic skin comprising asensing layer; and sides with pit structures of two elastomer films having pit structures are laminated and assembled in opposite to assemble the sensing layer. According to the invention, since thesensing layer has a unique laminated pit micro structure, the sensitivity of the electronic skin is enhanced based on the micro structure; and the electronic skin has excellent stability and is capable of detecting various signals like a sound signal and a sliding signal as well as a body motion state and a physiological signal and the like. The electronic skin has the potential of application tobody health management.

The invention relates to a cytoperm capable of being used as a hemolytic agent, which comprises the main components of saponin, sodium azide and paraformaldehyde. Proper amount of the components are mixed, and dissolved in phosphate buffer to prepare the cytoperm; and the cytoperm can be used as the hemolytic agent after dilution. Compared with the prior hemolytic agent and cytoperm, the cytoperm related to the invention can be directly used as the cytoperm, also can be used as the hemolytic agent after the dilution, and has double purposes. The hemolytic agent and cytoperm can be applied to a flow cytometer to detect various immunological indexes in human body blood, has obviously superior detection specificity, sensitivity and the like than imported reagents, and particularly has the advantages in pretreatment processes such as hemolysis, perm and the like on whole blood specimens of patients with leukemia, globalism and severe liver diseases.

The invention relates to an anti-aging photoelectric displacement sensor, which comprises a semiconductor substrate, an Al ZnO-doped film on the surface of the semiconductor substrate and two indium point electrodes on the surface of the film. The anti-aging photoelectric displacement sensor on the basis of lateral photovoltaic effects can be obtained by depositing the Al ZnO-doped film on the Si substrate through ultrasonic cleaning to replace a metal film layer in a metal- oxide-semiconductor structure. The nonlinear rate of the sensor can be controlled to be 3.22%, and the position sensitivity can reach 41.85mV/mm. As the Al ZnO-doped target material is directly used, the manufacturing technology is simple, and large-scale preparation in actual production can be realized.

The invention relates to the surprising finding that biomarkers corresponding to ACAA1, AP1M2, CGN, DDR1, EPS8L2, FASTKD1, GMIP, IKBKE, P2RX4, P4HB, PHKG2, PPFIBP2, PPP1 R16A, RASSF7, RNF183, SIRT6, TJP3, EFEMP2, S0CS2, and DCN are differentially expressed in control samples as compared to samples from patients having endometrial cancer and are therefore useful for detecting endometrial cancer. In particular these biomarkers having excellent sensitivity, specificity, and/or the ability to separate affected from non affected individuals. Furthermore, the inventors found that the differential expression of these biomarkers in primary endometrial cancer tumor tissue is correlated to their expression level in uterine fluid samples as compared to control values. Thus these biomarkers are robust in that they are found to be differentially expressed in several different types of samples from affected individuals.

A colored resin composition for a color filter is provided which can form a colored layer having excellent stability of sensitivity over time and excellent substrate adhesion, heat resistance and solvent resistance, and in which water stains during development are suppressed. This colored resin composition for a color filter contains a lake colorant, a dispersant, an alkali soluble resin, a polyfunctional monomer, an initiator and a solvent. The alkali soluble resin has a hydrocarbon ring and an ethylenic double bond, and has an acid value of 80-300 mgKOH/g. The content ratio of a silane coupling agent to the total solid content in the colored resin composition is 1 mass% or less.

The invention relates to a primer group and detection system for detecting HPV common hypotypes through a LAMP method. The HPV common hypotypes include HPV6, HPV11, HPV16, HPV42, HPV43 and HPV44. The primer group is composed of a primer sequence having a nucleotide sequence of SEQ NO.1-24. The primer group is designed according to the six hypotypes of condyloma acuminate and HPV infected by common skin warts, and the LAMP primers are verified. Through the reaction system above, the specific HPV hypotype DNA in a template can be effectively amplified. Through verification of specificity and sensitivity of the system, compared with a method for clinical application in the prior art, the LAMP system has superior sensitivity. Therefore, the invention provides a HPV type detection method that is simple and fast and is convenient in detection and high in specificity and sensitivity.

The invention relates to a method for measuring trace triptorelin. The trace triptorelin in a sample is measured by using a liquid chromatography and mass spectrometry technology. The method is simple in operations and accurate in results, and has good specificity and high sensitivity. The invention also relates to applications of the measurement method for the qualitatively or quantitatively measuring the content of the triptorelin in a biological sample and for pharmacokinetic studies of triptorelin preparations.

The invention relates to a key protein identification method based on protein clustering characteristics and activity co-expression. The method comprises the following specific steps: describing the clustering characteristics of a protein interaction network by utilizing an edge aggregation coefficient; setting gene activity expression by setting a threshold parameter, and describing by adopting aBoolean value; defining a calculation method based on the Boolean value of gene activity expression, and calculating the score of activity co-expression by utilizing a Jaccard coefficient; finally obtaining the key comprehensive scores based on the protein clustering characteristics and the activity co-expression, outputting a sorting result, and using the protein with the high key comprehensivescore after top sorting (top N is taken as a threshold value) as a key protein. According to the key protein identification method, the influence of gene expression data noise is eliminated, and the key protein identification method is superior to a centrality measurement method and a key protein prediction method with the same input data set in the aspects of identification accuracy, specificity,sensitivity and the like.

A gamma synuclein colloidal gold detection device comprises a strip base material. A sample pad, a colloidal gold conjugate pad, a reaction film and filter paper are sequentially arranged on the stripbase material. The colloidal gold conjugate pad is coated with colloidal gold marked rat anti-gamma synuclein monoclonal antibody alpha SNCG2; rat anti-gamma synuclein monoclonal antibody alpha SNCG1is sprayed to a testing area (T) of the reaction film; goat anti-mouse immune globulin IgG is sprayed to a quality control area (C). The colloidal gold detection device takes sodium casein as a stabilizing agent. The invention provides a preparation method and application of the gamma synuclein colloidal gold detection device. The gamma synuclein colloidal gold detection device has advantages that no other experimental equipment is needed in a detection process, low detection cost is realized, and a significant clinical value to diagnosis of carcinoma of urinary bladder, kidney cancer, prostatic cancer, endometrial cancer and breast cancer is achieved.

The invention discloses a high sensitivity toxic gas sensor and a preparation method thereof, and belongs to the technical field of physical detection. The sensor utilizes the characteristic that theadsorption effect of the edge of a two-dimensional material is obviously superior to that of the surface of the two-dimensional material, and a two-dimensional transition metal sulfur/selenide layer is designed as a multi-layer vertical alignment structure, so that the minimum detection limit can reach 0.01 ppm. The preparation method overcomes the technical difficulty of preparing the two-dimensional transition metal sulfur/selenide with the multi-layer vertical alignment structure, and provides a new idea for the field of toxic gas detection.

The invention discloses an application of a circRNA marker for diagnosing thalassemia, and belongs to the technical field of biology. The circRNA marker is hsa-circc-0129875 as shown in SEQ ID NO: 1,and the nucleotide sequence of the circRNA marker is shown in SEQ ID NO: 2. According to the circRNA marker provided by the invention, early diagnosis of thalassemia is realized; according to the invention, the circRNA marker and clinical examination indexes (HCT, MCV, MCH and MCHC) are combined to diagnose thalassemia. According to the invention, results show that the sensitivity of AUC diagnosedby combining hsa-circ-0129875 with clinical examination indexes is superior to that of AUC diagnosed by single circRNA, the area under an AUC curve is maximum, the sensitivity reaches 85% or above, and the specificity reaches 90% or above. The circRNA marker has the advantages of strong characteristics, strong sensitivity and stable result, provides a theoretical reference basis for the diagnosisof thalassemia, and has a wide clinical application prospect.

The invention discloses a preparation method of a high-sensitivity mirtazapine molecularly-imprinted electrochemical sensor. The high-sensitivity mirtazapine molecularly-imprinted electrochemical sensor is prepared by taking mirtazapine as template molecules, taking resveratrol as a functional monomer, taking azodiisobutyronitrile as an initiator, taking a nickel-based metal organic framework material as a doping agent and taking isoalantolactone as a crosslinking agent. The analysis method is simple and practical, and the defects of being complex, expensive in equipment and low in sensitivity of an original analysis method are overcome.

The invention relates to a method for simultaneously detecting five triterpene acid components in Cornus officinalis by utilizing a UFLC method. The method comprises the following steps: firstly, configuring reference solutions of ursolic acid, oleanolic acid, maslinic acid, korosorbic acid and betulinic acid respectively; performing chromatographic analysis on the reference solutions to obtain a peak area of each component respectively; using a sample volume of each reference solution as the abscissa and the peak area of each component in the reference solutions as the ordinate to draw a standard curve respectively; adding an extracting agent to Cornus officinalis powder, and extracting to obtain a sample solution; extracting and filtering the sample solution to obtain a filtrate as a test solution; performing chromatographic analysis on the test solution to obtain the peak area of each detected component in the test solution; and calculating to obtain the content of each component, so as to complete the simultaneous detection of five triterpene acid components in Cornus officinalis by utilizing the UFLC method. The method provided by the invention is used for analyzing and reaching components of Cornus officinalis by utilizing the UFLC method, significantly reduces analysis time, can obtain a good separation effect within 9 min, and also reduces the consumption of solvents and samples correspondingly.

The invention discloses a method for preparing a high-sensitivity pemoline molecular imprinting electrochemical sensor. According to the method, the high-sensitivity pemoline molecular imprinting electrochemical sensor is prepared from pemoline as template molecules, forsythoside as a functional monomer, azodiisobutyronitrile as an initiator, a copper-zinc double-metal organic frame material as a doping agent and acetylshikonin as a cross-linking agent. The analysis method is simple and practical, and defects that a conventional analysis method is complex, expensive in equipment and low in sensitivity can be overcome.

The invention discloses a thermochromic material of a malachite green-boric acid system, and a proportion confirmation test method. The thermochromatic material is a color-changing material in which substances are changed in color at different temperatures; and various thermochromic reasons such as crystal form transformation, structural change and the like of the substances at the different temperatures exist. The thermochromic material comprises, by weight, 1-3 parts of a color forming agent, 100-130 parts of a color developing agent and 10-500 parts of a solvent; the color forming agent ismalachite green; the color developing agent is boric acid; and the solvent is malonic acid, citric acid or tetradecanol. The method is used for the thermochromic material of the malachite green-boricacid system and proportion confirmation.

A prognosis risk assessment system for gastric cancer patients is characterized by comprising a gastric cancer methylation data acquisition module, a differential methylation site acquisition module and a prognosis model construction module. The gastric cancer methylation data acquisition module is used for acquiring TCGA gastric cancer methylation spectrum and a gastric cancer methylation spectrum data set GSE30601, the differential methylation site acquisition module is used for obtaining a plurality of hyper-methylation sites and a plurality of hypo-methylation sites, and the prognosis model construction module is used for constructing a 11-DNA methylation site risk scoring formula of each patient.

The invention discloses a marker for colorectal cancer or precancerous lesions and application thereof, and relates to the technical field of tumor detection. The marker of colorectal cancer or precancerous lesion is a CpG site of the NTMT1 gene. Through the methylation level of the CpG site of the NTMT1 gene, early screening or auxiliary diagnosis of colorectal cancer or precancerous lesions can be realized. The NTMT1 gene has very high sensitivity and specificity on a colorectal cancer sample or a precancerous lesion sample in an excrement sample. Through verification, the detection sensitivity and the specificity of the methylation of the NTMT1 gene are far higher than those of SDC2, TFPI2, MAP3K14-AS1 and Septine 9 genes, and the sensitivity of the NTMT1 gene to I/II stage colorectal cancer and progression stage adenoma in a blood sample and the specificity of the NTMT1 gene to other intestinal diseases are also better.

The invention discloses a dry chemical reagent light reflectance detector. The detector comprises a circuit board (1) and is characterized in that a photosensitive sensor (2) and an LED lamp holder (3) are installed on the circuit board (1), wherein the photosensitive sensor (2) is arranged in a light guiding drum (4) at the connecting surface of the lamp holder (3) and the circuit board in a sleeving manner, and the photosensitive sensor (2) is additionally provided with a diaphragm capable of alleviating the grounding interference of a reagent; a conical bulge (5) is arranged at the center of the other surface of the lamp holder (3), a groove (7) for installing an LED lamp (6) is formed in the periphery of the conical bulge (5), the LED lamp (6) and the photosensitive sensor (2) are bothelectrically connected with the circuit board (1), and lighting small holes (8) for reflecting reflected light of a dry chemical reagent are formed in the center of the conical bulge (5); a light guiding cover (9) is installed on one surface, far away from the circuit, of the LED lamp holder (3), and a light emitting hole (10) is formed in the center of the light guiding cover (9). According to the detector, the structure is simple, the illumination intensity is strong, the light path is simple, the reflected light directly enters the photosensitive sensor, and the anti-interference capability is strong.

The invention relates to an omnibearing tact switch comprising an outer wall sleeve and an inner wall sleeve, wherein the outer wall sleeve is arranged outside the inner wall sleeve, a silica gel gasket is embedded between the outer wall sleeve and the inner wall sleeve, and a positioning rubber ring is embedded between the bottom of the outer wall sleeve and the bottom of the inner wall sleeve. The pressed sensing type switch is characterized in that an LED switch does not need to be pressed by fingers all the times, which more conforms to the writing custom of an operator; and because the switch has smaller conduction pressure, the switch can be conduced by slight pressure.

A semiconductor photoresist composition and a method of forming patterns utilizing the same are provided. The semiconductor photoresist composition includes a condensed product produced by a condensation reaction between an organotin compound represented by Chemical Formula 1 and at least one organic acid compound selected from a substituted organic acid, an organic acid including at least two acid functional groups, and a substituted or unsubstituted sulfonic acid; and a solvent.

Specific details of Chemical Formula 1 are as defined in the specification.

The invention discloses a preparation method of a valpromide molecular imprinting electrochemical sensor. The high-sensitivity valpromide molecular imprinting electrochemical sensor doped with nanometer clay is prepared by using valpromide as a template molecule, secoxyloganin as a functional monomer, azodiisobutyronitrile as an initiating agent, nanometer clay as a doping agent and N-trans-feruloyltyramine as a cross-linking agent. The analysis method is simple and practical; the defects of complexity, expensive equipment and low sensitivity of a conversional analysis method are overcome.

The invention discloses application of mSEPT9 as a marker for predicting the postoperative recurrence risk of a colorectal cancer patient and in evaluating the effectiveness of a chemotherapy regimen. The mSEPT9 disclosed by the invention is remarkably superior to a traditional tumor marker (CEA, CA199 and CA242) in the aspects of sensitivity and specificity on the recurrence risk of a CRC patient, the recurrence prediction of the mSEPT9 is far earlier than that of imaging examination, and the median leading time is 5 months. Moreover, the most suitable patient groups of different chemotherapy regimens can be distinguished by detecting the mSEPT9, the postoperative recurrence of the patients is reduced, and the survival time is prolonged.

The invention relates to a method for preparing a pancreatic stone protein antibody and a method for detecting PSP (pancreatic stone protein), and belongs to the technical field of gene recombinationof bioengineering. The invention aims to provide the method for preparing the pancreatic stone protein antibody and the method for detecting PSP (pancreatic stone protein), so that a specific PSP immunogen is prepared, a PSP monoclonal antibody or polyclonal antibody is produced, the PSP detecting method is established, and a PSP in vitro diagnosis reagent kit is established. A tag-PSP recombinantprotein carrier is constructed through a gene recombination technique, a tag-PSP recombinant protein is expressed by bacteria, yeast, insect cells, animal cells or human cells, and the tag-PSP recombinant protein is purified to be used as a PSP recombinant protein immunogen. The method disclosed by the invention is used for detecting rise of the level of the PSP in blood, and can provide a reagent kit which can diagnose the generation of bacterial septicemia early, quickly and accurately, guide treatment of septicemia, monitor the progress of the septicemia and quickly detect the PSP by an immunology method.

Disclosed is a small lens system including a first lens, a second lens, a third lens, and a fourth lens sequentially arranged from an object along an optical axis, wherein the thickness (ct1) of the first lens, the thickness (ct3) of the second lens, the thickness (ct5) of the third lens, and the thickness (ct7) of the fourth lens satisfy ct1+ct3>ct5+ct7, ct1>ct3, ct1>ct5, and ct1>ct7, the front surface of the first lens is convex toward the object while the SAG amount of the first lens is increased depending on the height thereof, the refractive power (P2) of the second lens satisfies −0.01<P2<0.01, the front curvature (C3) and the rear curvature (C4) of the second lens satisfy |C3|<0.1 and |C4|<0.1, and the f-number of the lens system is less than 1.4.