A kind of medicine for treating adverse reaction of digestive tract of tumor radiotherapy and chemotherapy and preparation method thereof

A technology for adverse reactions, radiotherapy and chemotherapy, applied in the field of medicine, can solve problems such as unreportedness, and achieve the effect of reducing the number of retching and vomiting, and prolonging the incubation period of retching.

Active Publication Date: 2021-11-02
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many literatures about the isolation and identification of the chemical constituents of Pinellia, but none of the existing literature reveals which constituents can play a key role in nausea and vomiting

Method used

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  • A kind of medicine for treating adverse reaction of digestive tract of tumor radiotherapy and chemotherapy and preparation method thereof
  • A kind of medicine for treating adverse reaction of digestive tract of tumor radiotherapy and chemotherapy and preparation method thereof
  • A kind of medicine for treating adverse reaction of digestive tract of tumor radiotherapy and chemotherapy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1 Materials and methods

[0025] Cisplatin injection (20mg / branch); 5mg cyclic-(leucine-tyrosine) (dissolved in 2ml soybean oil for injection), 1mg isobathenone (dissolved in 2ml soybean oil for injection), 5mg cyclic -(leucine-tyrosine) and 1mg isobathenone compound preparation (dissolved with 2ml soybean oil for injection)

[0026] 2 experimental animals

[0027] Healthy adult mink, male, weighing 1.5-1.8 kg, was provided by the Animal Center of Heilongjiang University of Traditional Chinese Medicine. Each animal was individually placed in a 75cm×50cm×50cm iron cage, irradiated with natural light for 24 hours, and had free access to food and water before the experiment.

[0028] 3 Experimental methods

[0029] Grouping and administration of cisplatin as agonist experiment.

[0030] They were randomly divided into 5 groups, 10 rats in each group: normal control group, model control group, cyclo-(leucine-tyrosine) treatment group, isobathenone treatment group and com...

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Abstract

The invention relates to a medicine for treating adverse reactions of the digestive tract of tumor radiotherapy and chemotherapy and a preparation method thereof. The medicine of the present invention adopts cyclo-(leucine-tyrosine) and isubuthrenone as the active ingredients for treating adverse reactions of the gastrointestinal tract during radiotherapy and chemotherapy of tumors, thus the synergistic effect of the two active ingredients can be brought into play. It helps prolong the retching latency period of tumor patients undergoing radiotherapy and chemotherapy, and reduces the frequency of retching and vomiting.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a medicine for treating adverse reactions of digestive tract during radiotherapy and chemotherapy of tumors and a preparation method thereof. Background technique [0002] At present, radiotherapy and chemotherapy are the main means of tumor treatment. However, radiotherapy and chemotherapy can lead to many adverse reactions such as gastrointestinal reactions, bone marrow suppression, decreased immunity, organ weakness, and inflammation. Among them, gastrointestinal reactions are the most common. The incidence of adverse reactions was 77.5% to 97.4%. Gastrointestinal side effects of chemotherapy and radiotherapy include loss of appetite, nausea and vomiting, oral ulcers, abdominal pain, and diarrhea. At present, there are many drugs for the treatment of gastrointestinal side effects of radiotherapy and chemotherapy, including 5-hydroxytryptamine (5-HT) receptor ant...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/495A61K31/34A61P35/00A61P1/00A61P1/08A61K33/243
CPCA61K31/34A61K31/495A61P1/00A61P1/08A61P35/00A61K33/243A61K2300/00
Inventor 刘松江李全隋博文李雨宋爱英
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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