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Anti-cancer medical adhesive as well as preparation method and application thereof

A medical and functional technology, applied in the field of anti-cancer medical glue, anti-cancer medical glue and its preparation, can solve the problems of insufficient wound healing efficiency, difficulty in reducing tumor cell metastasis, etc. The effect of infection

Pending Publication Date: 2021-06-22
GUANGZHOU BAIYUN MEDICAL ADHESIVE CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved in one aspect of the present invention is to provide an anti-cancer medical glue, which solves the problems in the prior art that the wound healing efficiency after tumor surgery is insufficient and it is difficult to reduce the metastasis of tumor cells remaining in the wound and the probability of postoperative recurrence. It has achieved the technical effect of improving the efficiency of postoperative wound healing and reducing the metastasis of tumor cells remaining in the wound and the probability of postoperative recurrence

Method used

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  • Anti-cancer medical adhesive as well as preparation method and application thereof
  • Anti-cancer medical adhesive as well as preparation method and application thereof
  • Anti-cancer medical adhesive as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] 01. Preparation of high viscosity n-butyl cyanoacrylate medical adhesive:

[0054] High viscosity n-butyl α-cyanoacrylate 1:

[0055] First prepare poly n-butyl α-cyanoacrylate (P504): put α-butyl cyanoacrylate monomer in an airtight container at 40-50°C for 45-50 hours, the monomer forms a transparent Solid polymer, taking the polymer out of the container, and aging at 40-50°C for 10-15 hours to obtain a solid polymer of α-butyl cyanoacrylate.

[0056] Then take the prepared poly n-butyl cyanoacrylate solid 6.38g and soak in 42.1g n-butyl cyanoacrylate (504), and form high viscosity n-butyl cyanoacrylate 1 after continuous shaking for 7 days , its proportioning ratio is: 13.16%, viscosity is: 92.3 (pa.s), standby.

[0057] 02. Preparation of anticancer medical glue:

[0058] Preparation of low-viscosity anti-cancer medical glue:

[0059] Weigh 0.5283g artemisinin crystals (purity: 98%) and dissolve in 4.21ml α-n-butyl cyanoacrylate to obtain α-n-butyl cyanoacrylate...

Embodiment 2

[0061] 01. Preparation of high viscosity n-butyl cyanoacrylate medical adhesive:

[0062] High viscosity n-butyl α-cyanoacrylate 2:

[0063] Using polymethyl methacrylate (PMMA) as a thickener with a molecular weight of 200,000-800,000, weigh 2.36g of PMMA and soak it in 76.89g of α-n-butyl cyanoacrylate (504), and continue shaking for 10 days. Form high-viscosity n-butyl α-cyanoacrylate 2, PMMA content: 3%, viscosity: 96.5 (pa.s), set aside.

[0064] 02. Preparation of high-viscosity anti-cancer medical glue:

[0065] High viscosity anticancer medical glue 1:

[0066] Weigh 0.5283g of artemisinin crystals (purity: 98%) and dissolve them in 4.21ml of the above-mentioned standby high-viscosity n-butyl cyanoacrylate 1 to prepare a high-viscosity α-cyanoacrylate with an artemisinin content of 125mg / ml. N-butyl acrylate (504) stock solution.

[0067] Then dilute it with n-octyl α-cyanoacrylate (508) to 10mg / ml-50mg / ml to obtain high-viscosity anti-cancer medical glue 1, and it...

Embodiment 3

[0069] 01. Preparation of high viscosity n-butyl cyanoacrylate medical adhesive:

[0070] High viscosity n-butyl α-cyanoacrylate 2:

[0071] Using polymethyl methacrylate (PMMA) as a thickener with a molecular weight of 200,000-800,000, weigh 2.36g of PMMA and soak it in 76.89g of α-n-butyl cyanoacrylate (504), and continue shaking for 10 days. Form high-viscosity n-butyl α-cyanoacrylate 2, PMMA content: 3%, viscosity: 96.5 (pa.s), set aside.

[0072] 02. Preparation of anticancer medical glue:

[0073] High viscosity anticancer medical glue 2:

[0074] Weigh 0.8469g of artemisinin crystals (purity: 98%) and dissolve in 8.48ml of the above-mentioned standby high-viscosity n-butyl cyanoacrylate 2 to prepare high-viscosity α-cyanoacrylate with an artemisinin content of 100mg / ml. N-butyl acrylate (504) stock solution.

[0075] Then dilute it to 10mg / ml-50mg / ml with α-n-octyl cyanoacrylate (508) to obtain high-viscosity anti-cancer medical glue 2, and its artemisinin content i...

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Abstract

The invention relates to the technical field of medical materials, and discloses an anti-cancer medical adhesive. The medical adhesive is prepared from the following raw materials: artemisinin, alpha-cyanoacrylic acid n-butyl ester and alpha-cyanoacrylic acid n-octyl ester. The ratio of the artemisinin to the alpha-cyanoacrylic acid n-butyl ester to the alpha-cyanoacrylic acid n-octyl ester is any ratio. Through the anti-cancer effect of the artemisinin, the effects of stopping bleeding and closing an incision after a tumor operation and preventing tumor cell resection residues are achieved. The problems that in the prior art, the wound healing efficiency after a tumor operation is insufficient, and metastasis of tumor cells remaining on the wound and the postoperative recurrence probability are difficult to reduce are solved. Artemisinin is firstly dissolved in alpha-cyanoacrylic acid n-butyl ester, and then mutual dissolution with alpha-cyanoacrylic acid n-octyl ester in any proportion is achieved, and thus the beneficial effects of improving the healing efficiency of the postoperative wound and reducing the metastasis of tumor cells left in the wound and the postoperative recurrence probability are achieved. The invention also provides a preparation method and application of the anticancer medical adhesive.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an anti-cancer medical glue, especially an anti-cancer medical glue and its preparation method and application. Background technique [0002] α-Cyanoacrylate is currently the most widely used and most effective one, and has been approved by the US Food and Drug Administration (FDA) for clinical medicine. α-cyanoacrylate adhesives have the advantages of one-step operation, stable storage, and strong reactivity. They can quickly cross-link under various environmental conditions, and can also fill tissue defects and stimulate the growth of granulation tissue. Therefore, they are often used in skin injuries , is an attractive hemostatic material. In addition, α-cyanoacrylate has certain hemostatic and bacteriostatic properties. [0003] However, in the process of implementing the technical solution in the prior art, the applicant found the following technical problems ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04A61L24/00A61K47/32A61K31/366A61P35/00
CPCA61L24/046A61L24/0015A61K47/32A61K31/366A61P35/00A61L2300/216A61L2300/416A61L2300/418A61L2400/04C08L35/04
Inventor 杜宇聪谢剑波曾仑史志伟欧达欣
Owner GUANGZHOU BAIYUN MEDICAL ADHESIVE CO LTD
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