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Application of dexmedetomidine in promoting liver regeneration

A technology of dexmedetomidine and hepatocyte regeneration, applied in the field of biomedicine, can solve the problem of no article discussing the effect of DEX on liver regeneration, and achieve the effect of promoting liver cell regeneration

Pending Publication Date: 2021-06-29
RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, there are almost no articles in this technical field to explore the effect of DEX on liver regeneration

Method used

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  • Application of dexmedetomidine in promoting liver regeneration
  • Application of dexmedetomidine in promoting liver regeneration
  • Application of dexmedetomidine in promoting liver regeneration

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0064] 1. Experimental materials:

[0065] The B27 serum-free additive used in the present invention was purchased from Yuanpei Biological Co., Ltd.; N-acetyl-L-cysteine ​​(N-Acetylcysteine) and nicotinamide (Nicotinamide) were purchased from Sigma-Aldrich; recombinant protein hepatocyte growth factor (HGF), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and epithelial growth factor (FGF10) were purchased from Peprotech; small molecule compounds Rock inhibitor (Y-27632), TGF-β inhibitor (A- 83-01) was purchased from Tao Su Biochemical; Advance DMEM medium was purchased from Gibco Company; penicillin and streptomycin double combination antibiotics were purchased from Borui Biopharmaceutical Company; PBS buffer (Phosphate Buffer) used for washing and resuspending cells Solution) and Tryple were purchased from Gibco Company; fetal bovine serum (FBS) was purchased from Corning Company; low-adhesion well plates for cell culture were purchased from Corning ...

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Abstract

The invention relates to an application of dexmedetomidine in promoting liver regeneration, and belongs to the technical field of bio-medicines. The invention provides an application of dexmedetomidine in preparation of medicines for hepatocyte regeneration, and an application of an alpha2-adrenoreceptor agonist in preparation of medicines for hepatocyte regeneration. The dexmedetomidine and the alpha2-adrenoreceptor agonist activates an AKT / GSK3beta / beta-catenin signal pathway through the alpha2-adrenoreceptorso as to promote hepatocyte regeneration. The application of dexmedetomidine provides a new target and a new path for treatment and prognosis of liver diseases.

Description

technical field [0001] The invention relates to the application of dexmedetomidine in promoting liver regeneration and belongs to the technical field of biomedicine. Background technique [0002] The liver has a strong regenerative capacity and can regenerate after injury or resection, which is beneficial to recovery after partial hepatectomy and living donor liver transplantation [1]. However, insufficient function or small size of residual liver tissue or graft may lead to postoperative liver dysfunction, which is a major cause of morbidity and mortality [2-4]. In addition, donor grafts with regenerative dysfunction can lead to complications such as early allograft dysfunction (EAD) and primary non-function (PNF) after liver transplantation because It cannot meet the metabolic needs of the receptors [5]. A better understanding of liver regeneration could help address this issue. Liver regeneration involves hepatocyte growth factor HGF (hepatocyte growth factor), epiderm...

Claims

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Application Information

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IPC IPC(8): A61K31/4174A61K45/00A61P1/16A61P43/00
CPCA61K31/4174A61K45/00A61P1/16A61P43/00
Inventor 杨立群刘文明陈蔡旸
Owner RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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