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Crystal form of indolecarboxamide derivatives and preparation method thereof

A technology of crystal form and compound, applied in the crystal form of indole carboxamide derivatives and the field of preparation thereof, can solve the problems of less drugs and the like

Active Publication Date: 2022-04-12
JIANGSU HENGRUI MEDICINE CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although LYC-55716 has entered the clinical phase II, there are still very few drugs related to this target agonist, and no marketed drug has appeared. The published patents include WO2015171558, WO2008152260, WO2007068580, WO2007068579, WO2005056516, WO2005056510, WO2005060218, WO200506028, WO , it is still necessary to continue to develop new and more efficient RORγt agonists in order to provide patients with new and effective anticancer drugs

Method used

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  • Crystal form of indolecarboxamide derivatives and preparation method thereof
  • Crystal form of indolecarboxamide derivatives and preparation method thereof
  • Crystal form of indolecarboxamide derivatives and preparation method thereof

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Embodiment Construction

[0089] In the specification and claims of the present application, unless otherwise specified, the scientific and technical terms used herein have the meanings commonly understood by those skilled in the art. However, for a better understanding of the present invention, definitions and explanations of some related terms are provided below. In addition, when the definitions and explanations of terms provided in this application are inconsistent with the meanings commonly understood by those skilled in the art, the definitions and explanations of terms provided in this application shall prevail.

[0090] "X-ray powder diffraction pattern or XRPD" described in the present invention refers to according to Bragg's formula 2d sinθ=nλ (wherein, λ is the wavelength of X-ray, The order n of diffraction is any positive integer, generally take the first-order diffraction peak, n=1), when the X-ray is incident on the crystal or part of the crystal sample at the grazing angle θ (the compl...

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Abstract

The invention relates to crystal forms of indolecarboxamide derivatives and a preparation method thereof. The new crystal form of the compound represented by formula (I) has good stability and can be better used in clinical treatment.

Description

[0001] This application claims the priority of the Chinese patent application CN201910006064.5 with the filing date of January 4, 2019. This application cites the full text of the above-mentioned Chinese patent application. technical field [0002] The invention relates to a crystal form of indolecarboxamide derivatives and a preparation method thereof, belonging to the field of pharmacy. Background technique [0003] Retinoid-related orphan nuclear receptors (Retinoid-related orphan receptors, ROR) is a member of the nuclear receptor family and a ligand-dependent transcription factor, which can regulate a variety of physiological and biochemical processes, including reproductive development, Metabolism, immune system regulation, etc. (Mech Dev.1998 Jan, 70(1-2:147-53; EMBO J.1998 Jul15,17(14):3867-77). ROR family includes three types RORα, RORβ and RORγ (Curr Drug Targets Inflamm Allergy.2004Dec, 3(4):395-412), wherein RORγ can be expressed in many tissues, including thymu...

Claims

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Application Information

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IPC IPC(8): C07D209/12C07D401/12C07D401/14C07D401/06A61K31/404A61P27/00A61P35/00
CPCA61K31/404A61P27/00A61P35/00C07D209/12C07D401/06C07D401/12C07D401/14
Inventor 赵苗苗陈杰尤凌峰杜振兴王捷贺峰
Owner JIANGSU HENGRUI MEDICINE CO LTD
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