A hydrazine-containing indoleamine 2,3-bisoxidase inhibitor

A technology of group and alkyl group, applied in the field of IDO inhibitor containing hydrazine group and its preparation, can solve the problem of inability to directly regulate the immune response system of immune cells and the like
CN108689958BActive Publication Date: 2021-09-17NANJING HUAWE MEDICINE TECH DEV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING HUAWE MEDICINE TECH DEV
Publication Date
2021-09-17

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Abstract

The present invention provides a kind of IDO inhibitor shown in formula I and formula II and its preparation method, wherein R 1 , R 2 , The definition of the X group is as shown in the description. The present invention also provides a pharmaceutical composition containing the compound of formula I or formula II and its use. Use of the compound and a pharmaceutically acceptable salt thereof in the preparation of a disease drug related to indoleamine 2,3-dioxygenase (IDO), specifically in the treatment of cancer, Alzheimer's disease, depression, cataract and many other major diseases. The compound of the invention has high efficiency and low toxicity, has potential medical value and broad market prospect.
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Description

technical field

[0001] The art belongs to the field of antitumor drugs, and in particular relates to an IDO inhibitor containing a hydrazine group and a preparation method and application thereof. Background technique

[0002] Traditional tumor therapies are macromolecular or cell therapies, which target cell surface receptors and cannot directly regulate the huge and complex immune response system in immune cells. There are many immunosuppressive molecules in the tumor microenvironment. The immunotherapy strategy to improve the tumor immune microenvironment by regulating the function of these inhibitory molecules is called immunotherapy. This regulatory system involving hundreds of proteins has some nodes that may be related to PD. -1 has similar functions or synergistic effects with PD-1 antibodies, and these targets are most suitable for modulation by small molecule drugs. Therefore, immunotherapy is also known as a breakthrough in the history of tumor treatment. [000...

Claims

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