Pharmaceutical composition and application thereof in delaying senescence

A technology of anti-aging and composition, which is applied in the field of pharmacy, can solve the problems of lack of safe and effective drugs, etc., and achieve the effects of prolonging the overall life, prolonging the maximum life, and prolonging the overall life

A technology of anti-aging and composition, which is applied in the field of pharmacy, can solve the problems of lack of safe and effective drugs, etc., and achieve the effects of prolonging the overall life, prolonging the maximum life, and prolonging the overall life

CN113384579AActive Publication Date: 2021-09-14王世宣
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  • Pharmaceutical composition and application thereof in delaying senescence

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] S1. Preparation of food for common Drosophila

[0027] Formula: 12L distilled water, 900g cornmeal, 120g soybean powder, 100g agar, 800mL syrup, 150mL 10% butylparaben, 30mL levofloxacin

[0028] Pour the yeast, cornmeal, soybean powder and agar dissolved in distilled water into the pot respectively, and stir well. Add 800mL of syrup while stirring, then stir for 30min, then heat with 2300W power, cook for 1.5 hours, stop the fire and add 150mL of butylparaben, let it stand for 2min, then pour it out.

[0029] S2, Multiplication of Drosophila

[0030] Drosophila were cultured in a newly configured ordinary medium, and an average of 20 pairs of male and female Drosophila were placed in each tube. After the third instar larvae were pupated, the adult flies were removed and killed, and the unmated adult flies that had emerged within 8 hours were collected, separated into males and females, 400 each, and randomly divided into 4 groups. Cultured in normal medium for later...

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Abstract

The invention relates to the technical field of pharmacology, and particularly relates to a pharmaceutical composition and application thereof in delaying senescence. The pharmaceutical composition comprises felinone and piperlongumine, wherein the molar ratio of felinone to piperlongumine is (0.5-2): (1-4). The pharmaceutical composition capable of effectively delaying senescence is found, that is, after felinone and piperlongumine are compounded, drosophila melanogaster is treated, senescence of drosophila melanogaster can be effectively delayed, and the maximum life of drosophila melanogaster is prolonged. The pharmaceutical composition has great significance in the fields of delaying senescence and prolonging the overall life.

Description

technical field [0001] The invention relates to the technical field of pharmacy, in particular to a pharmaceutical composition and its application in delaying aging. Background technique [0002] With the continuous development of society and economy and the improvement of people's requirements for quality of life, the average life expectancy has been increased, but it is followed by increasingly serious problems of aging and aging-related diseases of the elderly population. Aging refers to the degenerative changes of body tissues and organ functions with age, which is the result of the joint action of various factors inside and outside the body. Aging can lead to stagnation of cell growth, impairment of tissue function and metabolism, and ultimately affect the lifespan of the body. [0003] As people's requirements for quality of life continue to increase, research on aging issues and anti-aging strategies has become a hot topic of the times. In recent years, the research...

Claims

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Application Information

Patent Timeline
14 Sep 2021
Publication
CN113384579A
IPC
A61K31/4412; A61K31/352; A61K36/804; A61K36/232; A61K36/815; A61K36/704; A61P39/06
CPC
A61K31/4412; A61K31/352; A61K36/804; A61K36/232; A61K36/815; A61K36/704; A61P39/06; A61K2300/00
Inventors
王世宣; 张金金