Aurkc gene snp locus associated with teratozoospermia and its application

A technology of deformed sperm and site, applied in the field of SNP site of AURKC gene

Active Publication Date: 2022-08-05
AFFILIATED HOSPITAL OF YOUJIANG MEDICAL UNIV FOR NATTIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports related to AURKC gene SNPs in the existing research on male teratospermia in my country. Therefore, the polymorphism analysis of AURKC gene SNPs is of great value in the auxiliary diagnosis and early warning of teratospermia.

Method used

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  • Aurkc gene snp locus associated with teratozoospermia and its application
  • Aurkc gene snp locus associated with teratozoospermia and its application
  • Aurkc gene snp locus associated with teratozoospermia and its application

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Embodiment 1

[0032] 1. Research objects

[0033] 1.1 Experimental subjects

[0034] Selected male patients with infertility who visited the Reproductive Center of the Affiliated Hospital of Youjiang Medical College for Nationalities from June 2019 to November 2019 as the research objects, and were divided into groups according to the percentage of normal spermatozoa. The percentage of normal spermatozoa was greater than or equal to 4% as the control group , the percentage of normal spermatozoa is less than 4% for the teratozoospermia group (case group). This study was approved by the Ethics Committee of the academy, and informed consent was signed.

[0035] 1.2 Patient inclusion and exclusion criteria

[0036] Deformity group: All the selected couples lived together with normal sex life for more than 12 months. All are infertile without contraception. Patients whose semen quality analysis is normal, but the percentage of spermatozoa with normal morphology is less than 4%. Diseases tha...

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Abstract

The invention discloses an AURKC gene SNP site related to teratozoospermia and its application, and belongs to the field of biotechnology. The invention provides the application of reagents for detecting rs56255892, rs758097 and rs758099 sites of AURKC genes in the preparation of teratozoospermia auxiliary diagnosis kits, which proves the AA and GA/AA genotypes of the rs758097 site and the A allele, rs758099 The CC genotype and C allele of the locus increase the risk of teratospermia, and individuals with haplotype G-G-T have a higher probability of teratospermia. The invention will help to further study the pathogenesis of male teratozoospermia in my country, and provide a tool for auxiliary diagnosis and early warning of teratozoospermia.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to an AURKC gene SNP site related to teratozoospermia and its application. Background technique [0002] In recent years, epidemiological experimental data from many countries have shown that human fertility has generally decreased, especially male fertility has decreased significantly, and male factors alone lead to more than 1 / 3 of infertility. Male teratozoospermia is defined as the percentage of normal spermatozoa less than 4%. Normal sperm morphology can ensure that all functions of sperm are normal. Abnormal sperm morphology will also affect the corresponding functions, thereby reducing sperm motility and the probability of combining with eggs, resulting in infertility. Any changes in the internal environment and damage to the physiological structure may lead to abnormal sperm morphology, thereby affecting male fertility. Among them, genetic abnormalities are the most common and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883C12Q1/6858C12N15/11
CPCC12Q1/6883C12Q1/6858C12Q2600/156C12Q2600/16C12Q2600/172C12Q2531/113C12Q2537/143C12Q2533/101
Inventor 廖碧云王俊利韦玉霞杨风莲刘中林胡林林李庭树
Owner AFFILIATED HOSPITAL OF YOUJIANG MEDICAL UNIV FOR NATTIES
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