Nano drug delivery system for targeted therapy of cerebral arterial thrombosis and preparation method of nano drug delivery system
A nano-drug loading technology for ischemic stroke, applied in the field of medicine, can solve the problems of special therapeutic drugs without pathological changes of ischemic stroke, dosage form restrictions, etc., and achieve high blood-brain barrier permeability and good cell entry Internal and overcoming neurotoxic effects
Pending Publication Date: 2021-11-02
周宇
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Problems solved by technology
[0007] The present invention aims to solve the problems in the prior art due to the existence of the blood-brain barrier and the limitation of drug dosage forms. At present, there is no specific therapeutic drug for the pathological changes of ischemic stroke in clinical practice. Generally, the cause of the disease is quickly relieved, that is, thrombolytic therapy. Lord's question
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Embodiment 1
[0048] The nano-drug loading system for targeted therapy of ischemic stroke provided in this example utilizes nano-particle carriers to carry therapeutic drugs to achieve therapeutic effects.
[0049] The nanoparticle carrier of this embodiment has maleimide (MAL) residues and amino (NH 2 ) The core nanoskeleton of the stump links the cell surface chemokine receptor (CXCR4) antagonist through the action of an auxiliary cross-linking agent and then synthesizes it with glutathione (GSH) at normal temperature and pressure. The treatment described in this embodiment The drug can be Glyburide (Glyburide), which has a certain therapeutic effect on brain damage after stroke, can significantly inhibit cerebral edema after ischemic stroke, and effectively reduce mortality; The use of nanoparticle carriers to target glibenclamide in the treatment of stroke avoids the problems in the process of intravenous systemic administration.
[0050] The -MAL residue and -NH introduced by the nano...
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The invention relates to a nano drug delivery system for targeted therapy of cerebral arterial thrombosis and a preparation method of the nano drug delivery system. The nano drug delivery system for targeted therapy of cerebral arterial thrombosis comprises a nano-particle carrier and a therapeutic drug carried on the nano-particle carrier, the nano-particle carrier is synthesized by linking a core nano-skeleton with a cell surface chemokine receptor (CXCR4) antagonist under the action of an auxiliary cross-linking agent and then synthesizing the core nano-skeleton and glutathione (GSH) at normal temperature and normal pressure; and the core nano skeleton adopts a core nano skeleton with a maleimide (MAL) residue end and an amino group (NH2) residue end. The invention synthesizes a nano drug delivery system which has good biocompatibility, degradability and relatively high biological membrane permeability and can carry a plurality of compounds, so that the nano drug delivery system can penetrate a blood brain barrier to be gathered in a cerebral ischemia hypoxia region expressed by a high cell surface chemotactic receptor factor (CXCR4), and therapeutic drugs are directionally released while oxygen free radicals are removed.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a nano-drug loading system for targeted therapy of ischemic stroke and a preparation method thereof. Background technique [0002] Stroke is the second most common cause of death worldwide and the leading cause of abnormal limb dysfunction. Epidemiological surveys show that the incidence of stroke is increasing year by year no matter in developed or developing countries. About 17.5 million people die from cardiovascular and cerebrovascular diseases and their complications every year, ranking first in the death rate of all diseases, and the number of deaths from stroke is about 6.7 million. Due to the high mortality and disability rates of stroke, as well as the long-term treatment and recovery process and the uncertainty of prognosis, suffering from stroke is not only a catastrophic event for patients and families, but also a heavy burden for medical institutions and society. ...
Claims
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IPC IPC(8): A61K47/69A61K31/64A61K38/06A61K47/54A61K47/60A61P9/10
CPCA61K47/6935A61K47/60A61K47/545A61K31/64A61K38/063A61P9/10A61K2300/00
Inventor 周宇
Owner 周宇