A method for determining 35 chemical components illegally added to children's cough and asthma patches

A technology for relieving cough and asthma, and illegal addition, which is applied in measurement devices, scientific instruments, material separation, etc., and can solve the problems of single type of compound, few types of detection at one time, and complex processing of viscous rubber matrix.

Active Publication Date: 2022-02-08
潍坊市检验检测中心
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the national standards and some literatures have stipulated or discussed the illegal addition of chemical ingredients in Chinese patent medicines for cough and asthma and health food, but the types of compounds involved are single or there are few types of tests at one time, which cannot meet the needs of rapid and comprehensive testing; Moreover, due to the complicated pretreatment of the viscous rubber matrix in the patch, the drug is not easy to be extracted, and it is difficult to detect the added drug. There are few domestic and foreign literatures on the detection method of illegally added chemicals in the plaster medical device.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A method for determining 35 chemical components illegally added to children's cough and asthma patches
  • A method for determining 35 chemical components illegally added to children's cough and asthma patches
  • A method for determining 35 chemical components illegally added to children's cough and asthma patches

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] 1. Instruments and materials

[0053]LC-MS liquid mass spectrometry instrument: Shimadzu LC-20AD liquid phase, API4000+ mass spectrometer of AB Company of the United States; XSE-205DU electronic balance: sense weight 0.0001g, Swiss Mettler-Toledo company; 6875A type cryogenic grinder , American SPEX SamplePREP Company; ST16R centrifuge, American Thermo Fisher Corporation. Reference substances codeine phosphate (batch number: 171203-201005, content: 99.6%), dextromethorphan hydrobromide (batch number: 100201-201204, content: 94.8%), dioxpromazine hydrochloride (batch number: 100299-201803, Batch number: 99.8%), benproperine phosphate (batch number: 100237-201804, content: 99.8%), narcotine (batch number: 171224-201605, content: 100.0%), ambroxol hydrochloride (batch number: 100599-201905 , content: 99.9%), bromhexine hydrochloride (batch number: 100427-201903, content: 99.8%), albuterol (batch number: 100204-201103, content: 99.7%), ephedrine (batch number: 171241-20180...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
lengthaaaaaaaaaa
particle diameteraaaaaaaaaa
Login to view more

Abstract

The invention provides a method for determining 35 kinds of chemical components illegally added to children's anti-cough and anti-asthma patch, which comprises the following steps: freezing and grinding to prepare the test solution; Illegal addition of chemical ingredients in The method is fast, simple, and highly sensitive, and is suitable for qualitative screening and quantitative detection of 35 chemical components illegally added to children's cough and asthma patches of medical devices.

Description

technical field [0001] The invention relates to the technical field of drug detection, in particular to a method for determining 35 chemical components illegally added to children's cough-relieving and asthma-relieving patches. Background technique [0002] At present, the children's cough and asthma patch products on the Chinese market mainly include three categories: medicines, medical devices and non-drugs. Due to the advantages of convenient use, few side effects, and good compliance in children, the patch has become the first choice of many consumers for relieving cough and asthma. [0003] At present, the national standards and some literatures have stipulated or discussed the illegal addition of chemical ingredients in Chinese patent medicines for cough and asthma and health food, but the types of compounds involved are single or there are few types of tests at one time, which cannot meet the needs of rapid and comprehensive testing; Moreover, due to the complex pret...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/884
Inventor 陈燕齐衍超李磊郎益鹏赵海鹏祁立新
Owner 潍坊市检验检测中心
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap