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Three-photon deep tissue imaging method and device

An imaging method and a deep technology, applied in the computer field, can solve problems such as the reduction of the imaging signal-to-noise ratio, affect the image quality, and the attenuation of fluorescent photons, and achieve the effect of improving the imaging signal-to-noise ratio

Pending Publication Date: 2022-03-01
杭州涿溪脑与智能研究所
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Problems solved by technology

Especially in the process of three-photon deep tissue imaging, the emitted fluorescent photons will inevitably attenuate in the process of passing through the tissue, which will lead to a decrease in the imaging signal-to-noise ratio and affect the image quality

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Embodiment Construction

[0024] The technical solutions of the present invention will be clearly and completely described below in conjunction with the embodiments. Obviously, the described embodiments are part of the embodiments of the present invention, but not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0025] In describing the present invention, it should be understood that the terms "center", "longitudinal", "transverse", "length", "width", "thickness", "upper", "lower", "front", " Orientation indicated by rear, left, right, vertical, horizontal, top, bottom, inside, outside, clockwise, counterclockwise, etc. The positional relationship is based on the orientation or positional relationship shown in the drawings, which is only for the convenience of describing the present invention and simplifying the description, rat...

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Abstract

The invention discloses a three-photon deep tissue imaging method and device, and the method comprises the steps: capturing a low-signal-to-noise-ratio image from a three-photon microscope, and inputting the low-signal-to-noise-ratio image into a high-performance operation unit in a continuous data flow manner; processing the continuous data stream through a pre-trained data enhancement network deployed on the high-performance arithmetic unit to obtain an enhanced data stream with a high signal-to-noise ratio; and synchronously displaying the high signal-to-noise ratio data stream on a display. On the premise that the imaging temporal-spatial resolution is not affected, the three-photon deep tissue imaging signal-to-noise ratio is improved, the algorithm is embedded into a microscopic hardware device, and real-time denoising is achieved.

Description

technical field [0001] The invention relates to the field of computer technology, in particular to a three-photon deep tissue imaging method and device. Background technique [0002] Optical imaging plays an important role in both basic biological research and clinical diagnosis, and it provides a non-invasive, minimally invasive microscopic imaging method for studying biological tissues. The imaging of deep biological tissues has always been a major scientific challenge. The extremely uneven density distribution of tissues and the strong scattering of tissue components limit the resolution of imaging. [0003] Multiphoton microscopy is a powerful functional imaging technique that has been widely used in the observation of life phenomena in deep tissues. When observing with a traditional single-photon fluorescence microscope, a molecule or atom can only absorb one photon at a time and transition from the ground state to the excited state. And when the light intensity is hi...

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Application Information

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IPC IPC(8): G06T5/00G06N5/04G06N3/08G06N3/04
CPCG06N3/088G06N5/04G06T2207/10056G06T2207/20081G06T2207/20084G06T2207/20182G06T2207/10064G06N3/045G06T5/70
Inventor 吴嘉敏李奕昕戴琼海
Owner 杭州涿溪脑与智能研究所
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