Method for noninvasive screening of bronchial tuberculosis and expired gas segmented collection device

A technology of collecting device and exhaling breath, which can be used in inoculation and ovulation diagnosis, evaluation of respiratory organs, medical science, etc., and can solve the problems of many complications, high cost, and poor prognosis.

Pending Publication Date: 2022-04-15
THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

At present, clinically, after the patient sees the doctor due to the symptom, the doctor's experience is used to predict TBTB, and then combined with the bronchoscopy to confirm the diagnosis. In the late stage, the treatment is difficult, expensive, with many complications, and the prognosis is poor; and the identification of TBTB requires experienced and specialized clinicians, which often leads to missed diagnosis of TBTB
At present, there is no practical method or technology for non-invasive screening and screening of TBTB for a large number of tuberculosis patients.

Method used

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  • Method for noninvasive screening of bronchial tuberculosis and expired gas segmented collection device

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Embodiment 1

[0041] A method for noninvasive screening of bronchial tuberculosis, comprising the steps of:

[0042] Step 1, before nebulization: Let the subject's mouth completely cover the air inlet of the exhaled breath condensate collection device, calmly inhale through the nose and then calmly exhale through the mouth, and collect the subjects before nebulization. The exhaled breath condensate sample representing the large airway for ~2 seconds and the exhaled breath condensate sample representing the small airway for 3 to 10 seconds before nebulization; The exhaled breath condensate samples representing the small airways in the first 3 to 10 seconds were used as the first group of exhaled breath condensate samples;

[0043] Step 2, turn on the nebulizer, let the subject inhale the tuberculosis-specific secretory protein ESAT-6+CFP-10(EC) solution by nebulization, and induce the T lymphocytes in the lungs of the subject to release cytokines, which include γ-interferon;

[0044] Step ...

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Abstract

The invention discloses a method for noninvasive screening of bronchial tuberculosis and an exhaled air segmented collection device. The method comprises the following steps: step 1, collecting exhaled air condensate specimens representing a large airway 0-2 seconds before atomization and exhaled air condensate specimens representing a small airway 3-10 seconds before atomization of a subject as a first group of exhaled air condensate specimens; 2, a subject inhales a tuberculosis specific secretory protein ESAT-6 + CFP-10 solution in an aerosol mode; 3, collecting exhaled air condensate specimens representing the large airway after the subject is atomized for 0-2 seconds and exhaled air condensate specimens representing the small airway after the subject is atomized for 3-10 seconds as a second group of exhaled air condensate specimens; and 4, detecting the content of gamma-interferon in the first group of exhaled air condensate samples and the second group of exhaled air condensate samples respectively, and screening according to the ratio of gamma-interferon after atomization and before atomization. The purpose of noninvasive screening of tracheal bronchial tuberculosis is achieved by detecting the change of gamma-interferon in exhaled air condensate in a segmented manner.

Description

technical field [0001] The invention relates to the field of tracheobronchial tuberculosis screening, in particular to a method for non-invasive screening of bronchial tuberculosis and an exhaled gas segmental collection device. Background technique [0002] Tracheobronchial tuberculosis (TBTB) refers to tuberculosis that occurs in the mucosa, submucosa, smooth muscle, cartilage and adventitia of the trachea and bronchi, and is a special type of pulmonary tuberculosis. In addition to causing the same wasting symptoms as tuberculosis, TBTB can cause the patient's airway, including the central large airway, to be narrowed, obstructed, or even completely occluded in varying degrees, resulting in varying degrees of dyspnea, sputum discharge, recurrent infection, and pulmonary insufficiency. Inflammation, lung damage, and even death from suffocation are diseases with a high morbidity and mortality. [0003] Due to the insidious onset and lack of specific manifestations, TBTB is ...

Claims

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Application Information

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IPC IPC(8): A61B5/08A61B10/00
Inventor 郭述良胡前芳冯燕梅
Owner THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY
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