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Novel compounds for lightening skin

A compound and composition technology, applied in the field of new compounds, can solve problems such as skin irritation, adverse side effects, and low efficacy

Pending Publication Date: 2022-04-19
UNILEVER IP HLDG BV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, many known substances such as kojic acid tend to have low efficacy or may cause unwanted side effects such as skin irritation

Method used

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  • Novel compounds for lightening skin
  • Novel compounds for lightening skin
  • Novel compounds for lightening skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] N-(cyclohexyl(4-isopropoxyphenyl)methyl)tetrahydro-2H-pyran-4-amine

[0104]

[0105] 2-Bromopropane (30.2 g, 246 mmol) was added to 4-hydroxybenzaldehyde (20 g, 164 mmol) and potassium carbonate (K 2 CO 3 ) (45.3g, 328mmol) in a mixture of N,N-dimethylformamide (DMF) (150ml), and the mixture was stirred at 50°C until 4- Hydroxybenzaldehyde disappeared completely. The mixture was partitioned between ethyl acetate (EA) (300ml) and water (300ml), and the organic layer was washed with sodium sulfate (Na 2 SO 4 ), filtered and the solvent was removed in vacuo to give crude 4-isopropoxybenzaldehyde (26 g, 96%). A solution of 4-isopropoxybenzaldehyde (10 g, 61 mmol) in tetrahydrofuran (THF) (60 ml) was added to cyclohexylmagnesium bromide (12.6 g, 67.1 mmol - prepared from cyclohexyl bromide and magnesium) in THF ( 60 ml) and the solution was stirred at room temperature (RT) until consumption of 4-isopropoxybenzaldehyde as monitored by TLC. The mixture was partition...

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PUM

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Abstract

A novel compound is disclosed. Skin lightening compositions comprising the compounds and methods of lightening skin are also disclosed. In addition, methods of synthesizing the novel compounds are disclosed.

Description

technical field [0001] The present invention relates to novel compounds useful for reducing skin hyperpigmentation. Background technique [0002] Various cosmetic compositions are widely used by consumers. Use skin care cosmetics such as lotions and creams for benefits such as antiaging, reducing skin hyperpigmentation, and moisturizing. [0003] Skin, the outermost protective covering of living organisms, is more susceptible to exposure to factors such as sunlight, heat, moisture, pollution and dust. Overexposure to these factors can lead to conditions such as tanning, blotchy skin, hyperpigmentation, freckles, melasma, etc., which can further lead to, for example, less desirable uneven skin tone. [0004] One possible way to reduce such conditions is to ensure that exposure to the aforementioned influencing factors, especially sunlight, is minimized. It is generally believed that overexposure to the sun and thus the harmful UV rays it contains produces a tanning effect....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/24C07D309/14A61K8/49A61Q17/04A61Q19/00A61Q19/02
CPCC07D309/14C07D307/24A61Q19/02A61Q19/00A61K8/4973A61K8/498A61Q17/04A61K8/4986A61K8/19A61K8/25A61K8/27A61K8/29A61K8/347A61K8/35A61K8/365A61K8/37A61K8/675
Inventor J·G·罗萨
Owner UNILEVER IP HLDG BV
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