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Universal polypeptide vaccine and application thereof in preparation of medicine for treating/preventing pancreatic cancer

A peptide vaccine and a universal technology, applied in the field of universal peptide vaccines, can solve the problems of lack of preventive measures for pancreatic cancer and achieve the effect of reducing medical costs

Inactive Publication Date: 2022-06-03
HANGZHOU NEOANTIGEN THERAPEUTICS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there are no effective preventive measures against pancreatic cancer

Method used

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  • Universal polypeptide vaccine and application thereof in preparation of medicine for treating/preventing pancreatic cancer
  • Universal polypeptide vaccine and application thereof in preparation of medicine for treating/preventing pancreatic cancer
  • Universal polypeptide vaccine and application thereof in preparation of medicine for treating/preventing pancreatic cancer

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Experimental program
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Effect test

Embodiment 1

[0067] A universal polypeptide vaccine against the following 6 mutations: KRAS-G12R; KRAS-G12V; CDKN2A-H83Y; KRAS-Q61H; TP53-R248W; CDKN2A-P94L. The polypeptide sequences for the 6 mutations are specifically described in Table 1.

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Abstract

The invention discloses a universal polypeptide vaccine. The universal polypeptide vaccine comprises KRAS-G12R mutation; the universal polypeptide vaccine can be used for preparing medicines for treating / preventing cancers (pancreatic cancer). The universal polypeptide vaccine disclosed by the invention has a relatively good immunotherapy effect on pancreatic cancer.

Description

technical field [0001] The present invention relates to a universal polypeptide vaccine suitable for pancreatic cancer treatment and prevention. Background technique [0002] Pancreatic adenocarcinoma (PAAD) is a malignant tumor of the digestive tract with high degree of malignancy, which is difficult to diagnose and treat. Its morbidity and mortality have increased significantly in recent years, and it is one of the malignant tumors with the worst prognosis. According to the latest statistics from the National Cancer Society in 2017, there were 53,670 new cases of pancreatic cancer and 43,090 deaths in the United States. Compared with other malignancies, pancreatic cancer is the cancer with the closest new cases and deaths, which indirectly indicates the refractory nature of pancreatic cancer. On the other hand, the statistical report clearly pointed out that with the general improvement of tumor diagnosis and treatment in recent years, the survival rate of most malignant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K14/82C12N9/14A61K39/00A61P35/00A61P1/18
CPCA61P35/00A61K39/0011Y02A50/30
Inventor 莫凡周秀卿林志伟陈荣昌马治明刘慧敏
Owner HANGZHOU NEOANTIGEN THERAPEUTICS CO LTD
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