Construction method of gastrointestinal stromal tumor PDX model resistant to imatinib

A gastrointestinal stromal tumor and construction method technology, applied in the field of gastrointestinal stromal tumor PDX model construction, can solve problems such as difficult experiments, no gastrointestinal stromal tumor PDX model, and affecting treatment of patients, and achieve Avoid ineffective medication, facilitate research and analysis, and reduce the effect of drug side effects

Active Publication Date: 2022-06-28
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

[0004] However, there is no PDX model for patients with gastrointestinal stromal tumors in the prior art, let alone a PDX model of gastrointestinal stromal tumors resistant to imatinib, which makes it difficult to conduct experiments and affects the treatment of patients

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  • Construction method of gastrointestinal stromal tumor PDX model resistant to imatinib

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Embodiment Construction

[0024] The present invention will be further described below with reference to the accompanying drawings and embodiments, and the contents of the embodiments are not intended to limit the protection scope of the present invention.

[0025] The invention provides a method for constructing a PDX model of gastrointestinal stromal tumor resistant to imatinib, which can provide a new method for the research of gastrointestinal stromal tumor, and is convenient to determine the gastrointestinal stromal tumor Whether the patient is resistant to imatinib, which can help to personalize the treatment of the patient and reduce the side effects of the drug.

[0026] figure 1 Shown is a schematic flow chart of the construction method of the imatinib-resistant gastrointestinal stromal tumor PDX model of the present invention. like figure 1 As shown, the construction method of the PDX model of gastrointestinal stromal tumor resistant to imatinib of the present invention comprises the follow...

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Abstract

The invention relates to a construction method of a gastrointestinal stromal tumor PDX model resistant to imatinib. The construction method comprises the following steps: 1) screening patients; 2) sampling; 3) preparing transplanting blocks; (4) constructing a P0-generation immunodeficient mouse; (5) constructing P1, P2 and P3 generation immunodeficient mice; (6) administration is conducted on the P2 and P3 generation immunodeficient mice; and 7) determining the gastrointestinal stromal tumor PDX model resistant to the imatinib. The invention provides a new method for researching the gastrointestinal stromal tumor, and is convenient for determining whether a patient with the gastrointestinal stromal tumor is resistant to the imatinib or not, so that personalized treatment on the patient is facilitated, and the side effect of the medicine is reduced.

Description

technical field [0001] The invention belongs to the technical field of animal models, and relates to a method for constructing a PDX model, in particular to a method for constructing a PDX model of a gastrointestinal stromal tumor resistant to imatinib. Background technique [0002] Gastrointestinal stromal tumors are common mesenchymal tumors of the digestive tract, and imatinib is a drug used for gastrointestinal stromal tumors. However, imatinib is not effective for all patients with gastrointestinal stromal tumors, and some patients with stromal tumors have primary resistance to imatinib and may develop secondary resistance as the drug treatment progresses. Therefore, if the patients are not analyzed before or during the treatment, the direct or continuous administration of imatinib may be difficult to achieve the therapeutic effect, and it may bring huge side effects to the patients. [0003] Utilizing a patient-derived xenograft (PDX) model with better homogeneity to ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/027
CPCA01K67/027A01K2207/12A01K2227/105A01K2267/03
Inventor 杨建军王舒李宏伟聂勇战张杰徐光辉郑吉阳罗佳琳
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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