Composition of ginkgo internal ester B and its preparation and use thereof

A technology of ginkgolide and compound, which is applied to the compound field of ginkgolide B, can solve the problems of low bioavailability, slow oral absorption, difficult separation and purification of ginkgolide B, etc., and achieves reduction of softening focus and nuclear dissolution. degree of lightening effect

Inactive Publication Date: 2006-10-04
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because ginkgolide B is difficult to separate and purify, insoluble in water, slow oral absorption, and low bioavailability, the development and application of ginkgolide B preparations are restricted, and there is currently no ginkgolide B preparation on the market at home and abroad.

Method used

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  • Composition of ginkgo internal ester B and its preparation and use thereof
  • Composition of ginkgo internal ester B and its preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] A ginkgolide B·arginine complex. Prepared by the following method: take 2.5 grams of arginine, add 1000 ml of water to dissolve, heat to 80 ° C, add 5 grams of ginkgolide B that has been ground and passed through an 80-mesh sieve, heat to dissolve, add 2.0 grams of activated carbon for needles, and stir at room temperature for adsorption After 30 minutes, filter to remove charcoal, and spray-dry the filtrate to obtain the ginkgolide B·arginine complex.

Embodiment 2

[0054] A ginkgolide B·arginine complex. Prepared by the following method: take 2.5 grams of arginine, add 20 ml of ethanol to dissolve, heat to 60 ° C, add 5 grams of ginkgolide B that has been ground and passed through an 80 mesh sieve, stir until dissolved, filter, and the filtrate is concentrated and dried under reduced pressure. Obtained ginkgolide B · arginine complex.

Embodiment 3

[0056] A ginkgolide B meglumine complex. Prepare by the following method: Take 4 grams of meglumine, add 30 ml of absolute ethanol to dissolve, heat to 50 ° C, add 10 grams of ginkgolide B that has been ground and passed through an 80-mesh sieve, filter, and the filtrate is concentrated and dried under reduced pressure to obtain Ginkgo biloba Lactone B Meglumine Complex.

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Abstract

A ginkgolide compounds B with changed physical properties of ginkgolide B and high stability and water-solubility can be mixed with pharmacologically receptable carrier to obtain a composition used to treat ischemic apoplexy.

Description

technical field [0001] The invention relates to a compound of ginkgolide B; its preparation method; and also relates to the application of the compound as an active ingredient in the treatment of ischemic stroke. Background technique [0002] Ginkgolide is an effective substance extracted from the Chinese herbal medicine Ginkgo biloba. The substance can be further subdivided into ginkgolide A, B, C, bilobalide, etc. in terms of structure. The extraction method of ginkgolide has been described in detail. Bibliographical reports, for example, people such as Li Xingang introduced the laboratory extraction method of ginkgolide (seeing Li Xingang etc., the laboratory extraction method research of ginkgolide in ginkgo leaf, Chinese Journal of Pharmaceutical Industry 1998 No. 1 issue), Chinese patent Document CN1195665A introduces the extraction method of ginkgolide and the preparation containing ginkgolide. The method is to extract ginkgo leaves by boiling wa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D493/22A61K31/365A61K9/00A61P9/10C07D307/00
Inventor 肖伟戴翔翎凌娅李明慧尚强黄广伟毕宇安
Owner JIANGSU KANION PHARMA CO LTD
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