Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Peptide carrier

A carrier and leader peptide technology, applied in the field of peptide carriers, can solve problems such as unsatisfactory results

Inactive Publication Date: 2002-10-16
H MED INC
View PDF0 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there have been no satisfactory results in any of these efforts

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Peptide carrier
  • Peptide carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0014] The present invention relates to a peptide carrier capable of gene transfer without cell specificity and without inducing host immune response.

[0015] The peptide vector of the present invention consists of a leader peptide, linker DNA and desired genes. The leader peptide (seq.ID.No.1) has the structure shown below, and is expected to have cell membranes in various viruses with envelopes such as retroviruses and paramyxoviruses (paramixovirus) through analysis Fusion-competent proteins were deduced from their amino acid sequences. This sequence is introduced directly into the cell through the cell membrane.

[0016]

[0017] Ac-Gly-Leu-Gly-Ile-Ser-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gly-Arg-Arg-Cys

[0018] 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Mutation Ile Leu Arg Lys Leu

[0019] Ile

[0020] Arg

[0021] Gla

...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to a peptide vector comprising a leader peptide, a linker DNA, and a desired gene. This peptide vector can achieve gene transfer without cell specificity and does not induce host immune responses. <IMAGE>

Description

Background technique [0001] The present invention relates to a peptide carrier capable of gene transfer without cell specificity and without inducing host immune response. [0002] It is known that viral vectors are mainly used to introduce genes into living bodies by using their cell infiltration ability. These viral vectors include, for example, adenoviruses, herpesviruses, retroviruses, and the like. [0003] Adenovirus is a non-enveloped double-stranded DNA virus and causes mild upper respiratory tract infections, keratoconjunctivitis, gastroenteritis, etc. in humans. The adenoviral genome is approximately 36 kb and is readily manipulated using conventional recombinant DNA techniques. Cellular infiltration of the virus is initiated by binding the fiberknob protein of the adenovirus to the coxackie & Adenovirus receptor (CAR) on the cell surface. Virions are then introduced into cells by endocytosis of clathrin via the interaction of integrins (αvβ3, αvβ5) on the cell su...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/09C07K7/08C12N15/63C12N15/87C12P21/02
CPCC12N15/87C12N15/63
Inventor 蔡莹镇
Owner H MED INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com