Peptide carrier

A carrier and leader peptide technology, applied in the field of peptide carriers, can solve problems such as unsatisfactory results

Inactive Publication Date: 2002-10-16
H MED INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there have been no satisfactory results in any of these efforts

Method used

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Embodiment Construction

[0014] The present invention relates to a peptide carrier capable of gene transfer without cell specificity and without inducing host immune response.

[0015] The peptide vector of the present invention consists of a leader peptide, linker DNA and desired genes. The leader peptide (seq.ID.No.1) has the structure shown below, and is expected to have cell membranes in various viruses with envelopes such as retroviruses and paramyxoviruses (paramixovirus) through analysis Fusion-competent proteins were deduced from their amino acid sequences. This sequence is introduced directly into the cell through the cell membrane.

[0016]

[0017] Ac-Gly-Leu-Gly-Ile-Ser-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gly-Arg-Arg-Cys

[0018] 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Mutation Ile Leu Arg Lys Leu

[0019] Ile

[0020] Arg

[0021] Gla

...

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Abstract

The present invention relates to a peptide vector comprising a leader peptide, a linker DNA, and a desired gene. This peptide vector can achieve gene transfer without cell specificity and does not induce host immune responses. <IMAGE>

Description

Background technique [0001] The present invention relates to a peptide carrier capable of gene transfer without cell specificity and without inducing host immune response. [0002] It is known that viral vectors are mainly used to introduce genes into living bodies by using their cell infiltration ability. These viral vectors include, for example, adenoviruses, herpesviruses, retroviruses, and the like. [0003] Adenovirus is a non-enveloped double-stranded DNA virus and causes mild upper respiratory tract infections, keratoconjunctivitis, gastroenteritis, etc. in humans. The adenoviral genome is approximately 36 kb and is readily manipulated using conventional recombinant DNA techniques. Cellular infiltration of the virus is initiated by binding the fiberknob protein of the adenovirus to the coxackie & Adenovirus receptor (CAR) on the cell surface. Virions are then introduced into cells by endocytosis of clathrin via the interaction of integrins (αvβ3, αvβ5) on the cell su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N15/09C07K7/08C12N15/63C12N15/87C12P21/02
CPCC12N15/87C12N15/63
Inventor 蔡莹镇
Owner H MED INC
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