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Prepn process of Qingkailing injection and injection powder and its quality control method

A technology for injection powder and injection, which is applied in the field of improved preparation of Qingkailing injection or injection powder, which can solve the problems of cumbersome preparation method of Qingkailing powder injection, unfavorable large-scale production, and no public quality control.

Inactive Publication Date: 2003-09-10
GUIZHOU YIBAI PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Nevertheless, we can see that the preparation method of the above-mentioned Qingkailing powder injection is very cumbersome, which is not conducive to large-scale industrial production, and the quality of Qingkailing powder injection needs to be further improved
Secondly, the quality control of Qingkailing injection or injection powder for cholic acid, hyodeoxycholic acid, geniposide and chlorogenic acid is not disclosed in the prior art.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Cholic acid 32.5g Hyodeoxycholic acid 37.5g Baicalin 50g Mother-of-pearl powder 500g

[0031] Buffalo horn powder 250g Gardenia 250g Radix isatidis 2000g Honeysuckle extract 50g The detailed process steps for preparing powder injections are as follows: 1. Extraction and hydrolysis treatment of drugs:

[0032]① Preparation of gardenia extract: Weigh gardenia according to the prescription, add 6 times the amount of water, boil for 1 hour, filter, add 4 times the amount of water to the filter residue, boil for half an hour, filter, combine the filtrates, heat and concentrate to the weight of the raw materials After cooling, add concentrated ethanol under stirring to make the alcohol content reach 60%, refrigerate for 2-3 hours, filter with suction, take the clarified filtrate, wash the precipitate with 60% cold ethanol, combine the lotion and filtrate, Ethanol was recovered under reduced pressure, ultra-centrifuged at 10,000 rpm, refrigerated for 24 hours, filtered to obta...

Embodiment 2

[0050] Cholic acid 32.5g Hyodeoxycholic acid 37.5g Baicalin 50g Mother-of-pearl powder 500g

[0051] Buffalo horn powder 250g Gardenia 250g Radix isatidis 2000g Honeysuckle extract 50g The detailed process steps for preparing the injection are as follows: 1. Extraction and hydrolysis of the drug:

[0052] ① Preparation of gardenia extract: Weigh gardenia according to the prescription, add 6 times the amount of water, boil for 1 hour, filter, add 4 times the amount of water to the filter residue, boil for half an hour, filter, combine the filtrates, heat and concentrate to the weight of the raw materials After cooling, add concentrated ethanol under stirring to make the alcohol content reach 60%, refrigerate for 2-3 hours, filter with suction, take the clarified filtrate, wash the precipitate with 60% cold ethanol, combine the lotion and filtrate, Ethanol was recovered under reduced pressure, ultracentrifuged at 12000 rpm, refrigerated for 24 hours, filtered to obtain a clarifi...

Embodiment 3

[0070] Cholic acid 32.5g Hyodeoxycholic acid 37.5g Baicalin 50g Mother-of-pearl powder 500g

[0071] Buffalo horn powder 250g Gardenia 250g Radix isatidis 2000g Honeysuckle extract 50g The detailed process steps for preparing freeze-dried powder injection are as follows: 1. Extraction and hydrolysis treatment of drugs:

[0072] ① Preparation of gardenia extract: Weigh gardenia according to the prescription, add 6 times the amount of water, boil for 1 hour, filter, add 4 times the amount of water to the filter residue, boil for half an hour, filter, combine the filtrates, heat and concentrate to the weight of the raw materials After cooling, add concentrated ethanol under stirring to make the alcohol content reach 60%, refrigerate for 2-3 hours, filter with suction, take the clarified filtrate, wash the precipitate with 60% cold ethanol, combine the lotion and filtrate, Ethanol was recovered under reduced pressure, ultracentrifuged at 16000 rpm, refrigerated for 24 hours, filte...

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PUM

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Abstract

The present invention provides a improved preparation process of Qingkailing injection and powder for injection. The improved preparation process includes high speed centrifugal treatment in extracting cape jasmine, isatis root and honeysuckle, merging extractive liquid, ultrafiltering and other technological steps. It can produce Qingkailing injection product and powder product for injection with ever higher stability and ever longer effective period. The present invention also discloses the quality control method of baicalin, cholic acid, hyodeoxycholic acid, jasminoidin and chlorogenic acid in Qingkailing injection and powder for injectino as well as identification method of Qingkailing injection and power for injection.

Description

technical field [0001] The present invention relates to a preparation method of Qingkailing injection or injection powder and a quality control method of Qingkailing powder injection, specifically, an improved preparation method and Qingkailing injection or injection powder. The quality control method and identification method of Kailing injection or injection powder. Background technique [0002] Qingkailing Injection is based on the theory of traditional Chinese medicine by analyzing the dismantled formula of "Angong Niuhuang Pill" in Wu Jutong's "Warm Disease Tiaobian" in the Qing Dynasty. It is widely used clinically for patients with high fever and stroke, and is recognized and commonly used by medical staff as first-aid medicine. Research on Qingkailing preparations began as early as the 1970s, and dosage forms such as "Qingkailing Injection", "Qingkailing Oral Liquid" and "Qingkailing Granules" were successively released and applied in clinic. However, due to the in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/14A61K33/10A61K35/32A61P9/10A61P29/00
Inventor 蔡剑前
Owner GUIZHOU YIBAI PHARMA CO LTD
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