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Method for identifying medicinal materials using characteristic atlas

A technology of characteristic maps and medicinal materials, applied in the field of identification of traditional Chinese medicinal materials based on characteristic maps, can solve the problems of low relative content and high system, and achieve the effects of good specificity and objectivity, low system requirements, and good category characteristics

Inactive Publication Date: 2005-03-02
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the relative content of the characteristic chromatographic peaks selected in the current characteristic chromatogram is still low. When detecting them, the system requirements are high, and they may not be able to be detected and reproduced stably in the routine detection of chromatography.
The selection of characteristic peaks is only determined by observation and experience, with a certain degree of subjectivity

Method used

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  • Method for identifying medicinal materials using characteristic atlas
  • Method for identifying medicinal materials using characteristic atlas
  • Method for identifying medicinal materials using characteristic atlas

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Identification of American ginseng and Panax ginseng by liquid chromatography-mass spectrometry

[0026] Main instruments:

[0027] Liquid chromatography mass spectrometry: Agilent, 1100 Series LC / MSD Trap; ESI source. Chromatographic column: Phenomenex Prodigy C18 column, 4.6 mm×250 mm, particle size 5 μm.

[0028] Materials and Reagents:

[0029] Ginseng (Panax.ginseng) was collected from Zuojia, Jilin Province, Fusong, Jilin Province, red ginseng was purchased from the ginseng antler market of Jilin Agricultural University; American ginseng (P.quinquefolius) was collected from Huairou, Beijing, Zuojia, Jilin Province, North America American ginseng was provided by Wisconsin (sound) company. The above medicinal materials have been identified by Dr. Xiao Shengyuan.

[0030] Methanol and acetonitrile were chromatographically pure and were purchased from Fisher Company; ammonia water and glacial acetic acid were analytically pure and were purchased from Be...

Embodiment 2

[0086] Example 2: Identification of American ginseng and Panax ginseng by liquid chromatography-mass spectrometry

[0087] main instrument

[0088] Liquid chromatography mass spectrometry: Agilent, 1100 Series LC / MSD Trap; ESI source. Chromatographic column: Phenomenex Prodigy C18 column, 4.6 mm×250 mm, particle size 5 μm.

[0089] Materials and Reagents

[0090] Ginseng (Panax.ginseng) was collected from Zuojia, Jilin Province, Fusong, Jilin Province, red ginseng was purchased from the ginseng antler market of Jilin Agricultural University; American ginseng (P.quinquefolius) was collected from Huairou, Beijing, Zuojia, Jilin Province, North America American ginseng was provided by Wisconsin (sound) company.

[0091] Methanol and acetonitrile were chromatographically pure and were purchased from Fisher Company; ammonia water and glacial acetic acid were analytically pure and were purchased from Beijing Chemical Plant.

[0092] Chromatographic conditions

[0093] Injection...

Embodiment 3

[0150] Example 3: The feature map is used for the classification of American ginseng and wild ginseng (ginseng and wild ginseng are regarded as one type).

[0151] main instrument

[0152] Liquid chromatography mass spectrometry: Agilent, 1100Series LC / MSD Trap; ESI source. Chromatographic column: YMC-Packph column, 2.0mm×250mm, particle size 5μm.

[0153] Materials and Reagents

[0154] Ginseng (Panax.ginseng) was collected from Zuojia, Jilin Province, Fusong, Jilin Province, red ginseng was purchased from the ginseng antler market of Jilin Agricultural University; American ginseng (P.quinquefolius) was collected from Huairou, Beijing, Zuojia, Jilin Province, North America American ginseng was provided by Wisconsin (sound) company. The above medicinal materials have been identified by Dr. Xiao Shengyuan.

[0155] Methanol and acetonitrile were chromatographically pure and were purchased from Fisher Company; ammonia water and glacial acetic acid were analytically pure and ...

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Abstract

The invention relates to a identification method for drugs with characteristic graphoes. The method acquire the characteristic graphoes with liquid phase chromaspectrum-mass spectrum combining technology and identify medicine with the characteristic graphoes. The identification method provided by the invention is based on the characteristic graphoes,the steps includes data acquirement, chromatography matching, the data normalization processing,the characteristic selection and the characteristic graphoes establishment. The invention has the following advantages and remarkable effect compared to the current method of adopting the original fingerprint map to identify drugs: 1)the specification of the data acquisition system is low,the characteristic graphoes has good stability, specificity and objectivity; 2)the characteristic graphoes causes the increas of the difference of the sample in the same category and between the different categories, getting better category charateristics, its identifying ability is better than the original fingerprint graphoes; 3)the identification result of the drugs is accurate, available and reliable.

Description

technical field [0001] The invention relates to a method for identifying medicinal materials by using atlases, in particular to a method for identifying traditional Chinese medicinal materials based on characteristic atlases. Background technique: [0002] In the field of identification of traditional Chinese medicine, identification of varieties of traditional Chinese medicine has always been the main content of research. Traditional character identification, tissue microscopic identification and physical and chemical identification have played a huge role in the identification of Chinese herbal medicines. However, with the development of the times, the forms of medicine and administration of traditional Chinese medicine are also constantly changing, and the application of traditional identification methods to the identification of Chinese patent medicines produced by modern methods is limited. People are gradually using modern instruments and analysis methods for the iden...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/86G01N30/88
Inventor 罗国安聂磊王义明
Owner TSINGHUA UNIV
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